The Engineered Hexosaminidase

Humans Hexosaminidases Glycosylation beta-N-Acetylhexosaminidases / chemistry Glycosyltransferases Glycoside Hydrolases / metabolism

Journal

Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623

Informations de publication

Date de publication:
15 08 2023
Historique:
medline: 16 8 2023
pubmed: 27 7 2023
entrez: 27 7 2023
Statut: ppublish

Résumé

Engineering glycoside hydrolases is a major route to obtaining catalysts forming glycosidic bonds. Glycosynthases, thioglycoligases, and transglycosylases represent the main strategies, each having advantages and drawbacks. Here, we show that an engineered enzyme from the GH84 family, the acid-base mutant

Identifiants

DOI: 10.1021/acs.biochem.3c00236 PMID: 37498728
pubmed: 37498728
doi: 10.1021/acs.biochem.3c00236
doi:

Substances chimiques

Hexosaminidases EC 3.2.1.-
beta-N-Acetylhexosaminidases EC 3.2.1.52
Glycosyltransferases EC 2.4.-
Glycoside Hydrolases EC 3.2.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2358-2362

Auteurs

Agnes B Petersen (AB)

Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
Department of Chemistry, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
Department of Biotechnology and Food Science, Norwegian University of Science and Technology, N-7491 Trondheim, Norway.
ORCID: 0000-0002-6100-3032

Seyed Hossein Mirbarati (SH)

Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.

Birte Svensson (B)

Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
ORCID: 0000-0002-2993-8196

Jens Ø Duus (JØ)

Department of Chemistry, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
ORCID: 0000-0003-3625-1250

David Teze (D)

Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
ORCID: 0000-0002-6865-6108

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Engineered Hexosaminidase
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Hexosaminidases › The Engineered Hexosaminidase
questionsmedicales.fr › Métabolisme › Métabolisme glucidique › Glycosylation › The Engineered Hexosaminidase
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Hexosaminidases › beta-N-Acetylhexosaminidases › The Engineered Hexosaminidase
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › The Engineered Hexosaminidase
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › The Engineered Hexosaminidase