Therapeutic resistance to anti-oestrogen therapy in breast cancer.
Journal
Nature reviews. Cancer
ISSN: 1474-1768
Titre abrégé: Nat Rev Cancer
Pays: England
ID NLM: 101124168
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
accepted:
29
06
2023
medline:
27
9
2023
pubmed:
28
7
2023
entrez:
27
7
2023
Statut:
ppublish
Résumé
The hormone receptor oestrogen receptor-α (ER) orchestrates physiological mammary gland development, breast carcinogenesis and the progression of breast tumours into lethal, treatment-refractory systemic disease. Selective antagonism of ER signalling has been one of the most successful therapeutic approaches in oncology, benefiting patients as both a cancer preventative measure and a cancer treatment strategy. However, resistance to anti-oestrogen therapy is a major clinical challenge. Over the past decade, we have gained an understanding of how breast cancers evolve under the pressure of anti-oestrogen therapy. This is best depicted by the case of oestrogen-independent mutations in the gene encoding ER (ESR1), which are virtually absent in primary breast cancer but highly prevalent (20-40%) in anti-oestrogen-treated metastatic disease. These and other findings highlight the 'evolvability' of ER
Identifiants
pubmed: 37500767
doi: 10.1038/s41568-023-00604-3
pii: 10.1038/s41568-023-00604-3
pmc: PMC10529099
mid: NIHMS1928016
doi:
Substances chimiques
Estrogens
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
673-685Subventions
Organisme : NCI NIH HHS
ID : K12 CA184746
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
© 2023. Springer Nature Limited.
Références
Endocr Relat Cancer. 2015 Oct;22(5):713-24
pubmed: 26162914
Nat Rev Clin Oncol. 2015 Oct;12(10):573-83
pubmed: 26122181
Nat Rev Cancer. 2017 Jan;17(1):54-64
pubmed: 27885264
ChemMedChem. 2020 Nov 18;15(22):2072-2097
pubmed: 32916035
Breast Cancer Res. 2014 Jan 22;16(1):R7
pubmed: 24451109
Science. 1995 Dec 1;270(5241):1491-4
pubmed: 7491495
Cell. 2019 Aug 8;178(4):949-963.e18
pubmed: 31353221
Mol Cell. 2007 Sep 7;27(5):691-700
pubmed: 17803935
Cancer Discov. 2022 Feb;12(2):356-371
pubmed: 34544752
J Steroid Biochem Mol Biol. 2009 Sep;116(3-5):187-90
pubmed: 19500671
Biochemistry. 1997 Dec 2;36(48):14897-905
pubmed: 9398213
Cancer Cell. 2018 Sep 10;34(3):427-438.e6
pubmed: 30205045
Clin Cancer Res. 2020 Nov 15;26(22):5974-5989
pubmed: 32723837
N Engl J Med. 2019 May 16;380(20):1929-1940
pubmed: 31091374
Cancer Cell. 2018 Dec 10;34(6):893-905.e8
pubmed: 30537512
Cancer Discov. 2018 Sep;8(9):1176-1193
pubmed: 29991605
Cancer Res. 2012 Jan 15;72(2):548-59
pubmed: 22108824
BMC Cancer. 2008 May 28;8:149
pubmed: 18507821
Virchows Arch. 2022 Jan;480(1):163-176
pubmed: 35029776
Nat Rev Drug Discov. 2022 Mar;21(3):181-200
pubmed: 35042991
Oncogene. 2021 Feb;40(5):997-1011
pubmed: 33323970
Oncogene. 2017 Apr 20;36(16):2255-2264
pubmed: 27748766
Science. 2022 Jan 14;375(6577):eabc1495
pubmed: 35025636
Cancers (Basel). 2021 Oct 17;13(20):
pubmed: 34680352
Cancers (Basel). 2022 Oct 24;14(21):
pubmed: 36358625
J Clin Oncol. 2020 Apr 20;38(12):1346-1366
pubmed: 31928404
Cancer Discov. 2015 Jan;5(1):72-81
pubmed: 25380844
Mod Pathol. 2010 Feb;23(2):205-12
pubmed: 19898421
Cell Rep. 2019 Mar 5;26(10):2667-2680.e7
pubmed: 30840889
Anticancer Drugs. 2015 Oct;26(9):948-56
pubmed: 26164151
Clin Cancer Res. 2004 Jan 1;10(1 Pt 2):331S-6S
pubmed: 14734488
Oncotarget. 2017 May 9;8(19):31347-31354
pubmed: 28430626
Oncogene. 2018 Aug;37(33):4581-4598
pubmed: 29748621
Mol Endocrinol. 2005 Jun;19(6):1543-54
pubmed: 15802375
Nat Commun. 2016 May 13;7:11579
pubmed: 27174596
Nat Genet. 2013 Dec;45(12):1446-51
pubmed: 24185510
Breast Care (Basel). 2020 Aug;15(4):347-354
pubmed: 32982644
J Clin Oncol. 2016 Sep 1;34(25):2961-8
pubmed: 27269946
Breast Cancer Res Treat. 1994;31(1):95-105
pubmed: 7981461
Cancer Res. 1988 Sep 15;48(18):5183-7
pubmed: 3409244
Nature. 2012 Oct 4;490(7418):61-70
pubmed: 23000897
Cell Rep. 2013 Sep 26;4(6):1116-30
pubmed: 24055055
Eur J Cancer. 2003 Aug;39(12):1684-9
pubmed: 12888362
NPJ Breast Cancer. 2018 Aug 2;4:22
pubmed: 30083595
J Steroid Biochem Mol Biol. 1990 Dec 20;37(6):771-5
pubmed: 2285589
Mol Cancer Res. 2016 Nov;14(11):1054-1067
pubmed: 27565181
Cancer Metastasis Rev. 2022 Dec;41(4):975-990
pubmed: 36229710
Sci Adv. 2022 Aug 26;8(34):eabm4358
pubmed: 36001652
Genes Dev. 2010 Oct 1;24(19):2219-27
pubmed: 20889718
Mol Cell Biol. 1993 Jun;13(6):3577-87
pubmed: 8497271
Sci Transl Med. 2015 Nov 11;7(313):313ra182
pubmed: 26560360
Clin Cancer Res. 2020 Dec 1;26(23):6149-6157
pubmed: 32988969
Semin Cancer Biol. 2022 Nov;86(Pt 2):14-27
pubmed: 36041672
Breast Cancer. 2006;13(1):74-83
pubmed: 16518065
Mol Cell Oncol. 2018 Oct 9;5(6):e1526005
pubmed: 30525098
Nat Genet. 2013 Dec;45(12):1439-45
pubmed: 24185512
CA Cancer J Clin. 2019 Nov;69(6):438-451
pubmed: 31577379
Breast. 2021 Aug;58:160-169
pubmed: 34087775
Cancer Treat Rev. 2022 Sep;109:102432
pubmed: 35839531
Cold Spring Harb Perspect Biol. 2010 Dec;2(12):a003178
pubmed: 20739412
Pharmacol Ther. 2018 Jun;186:1-24
pubmed: 29289555
Cold Spring Harb Perspect Med. 2017 Feb 1;7(2):
pubmed: 28003276
Front Immunol. 2019 Mar 01;10:348
pubmed: 30881360
Science. 2022 Sep 9;377(6611):1180-1191
pubmed: 35981096
J Natl Cancer Inst. 2003 Mar 5;95(5):353-61
pubmed: 12618500
Biochem Pharmacol. 2011 Jul 15;82(2):122-30
pubmed: 21501600
Ann Oncol. 2018 Jan 1;29(1):145-153
pubmed: 29045530
Cancer Res. 2001 May 1;61(9):3632-9
pubmed: 11325832
Endocrinology. 2001 Feb;142(2):838-46
pubmed: 11159857
Br J Cancer. 2004 Nov 1;91(9):1687-93
pubmed: 15477868
Nat Commun. 2017 Nov 30;8(1):1865
pubmed: 29192207
Sci Transl Med. 2022 Sep 21;14(663):eabo5959
pubmed: 36130016
Cancer Discov. 2020 Feb;10(2):198-213
pubmed: 31806627
J Med Chem. 1994 May 27;37(11):1550-2
pubmed: 8201587
Mol Cancer Ther. 2022 Jun 1;21(6):890-902
pubmed: 35642432
Oncogene. 2017 Apr 20;36(16):2286-2296
pubmed: 27748765
CA Cancer J Clin. 2022 Nov;72(6):524-541
pubmed: 36190501
Cancer Res. 2013 Dec 1;73(23):6856-64
pubmed: 24217577
Breast Cancer Res. 2017 May 23;19(1):60
pubmed: 28535794
Nat Rev Cancer. 2003 Nov;3(11):821-31
pubmed: 14668813
Nat Rev Clin Oncol. 2020 Jun;17(6):360-371
pubmed: 32152485
Nat Rev Cancer. 2018 Jun;18(6):377-388
pubmed: 29662238
Clin Cancer Res. 2014 Apr 1;20(7):1757-1767
pubmed: 24398047
Eur J Cancer. 2008 Jan;44(1):30-8
pubmed: 18068350
Ther Adv Med Oncol. 2022 Jul 30;14:17588359221113694
pubmed: 35923930
Breast Cancer Res Treat. 1988 Apr;11(1):37-43
pubmed: 3289634
Cancers (Basel). 2022 Feb 16;14(4):
pubmed: 35205742
Cancer Discov. 2017 Mar;7(3):277-287
pubmed: 27986707
J Natl Cancer Inst. 2006 Sep 20;98(18):1285-91
pubmed: 16985247
Mol Cell. 2005 May 13;18(4):413-24
pubmed: 15893725
Elife. 2016 Feb 02;5:
pubmed: 26836308
Sci Transl Med. 2017 Aug 9;9(402):
pubmed: 28794284
Cancer Res. 2017 Oct 15;77(20):5602-5613
pubmed: 28904064
Cancer Cell. 2020 Oct 12;38(4):534-550.e9
pubmed: 32888433
Cancer Res. 1997 Apr 1;57(7):1244-9
pubmed: 9102207
J Clin Oncol. 2000 Nov 15;18(22):3748-57
pubmed: 11078487
Ann Oncol. 2019 Jan 1;30(1):115-123
pubmed: 30423024
Endocr Relat Cancer. 2003 Jun;10(2):179-86
pubmed: 12790780
Future Oncol. 2019 Oct;15(28):3209-3218
pubmed: 31426673
J Clin Oncol. 2022 Aug 20;40(24):2789-2805
pubmed: 35839445
N Engl J Med. 2022 Jul 7;387(1):9-20
pubmed: 35665782
JAMA. 2019 Jan 22;321(3):288-300
pubmed: 30667505
Mol Cell Endocrinol. 2019 Aug 1;493:110452
pubmed: 31125586
Clin Cancer Res. 2003 Apr;9(4):1259-66
pubmed: 12684393
Cancer Res. 1994 May 15;54(10):2552-5
pubmed: 8168078
J Med Chem. 2021 Aug 26;64(16):11841-11856
pubmed: 34251202
Nature. 2019 Jul;571(7765):408-412
pubmed: 31243370
Endocrinology. 2003 Mar;144(3):1032-44
pubmed: 12586780
N Engl J Med. 2020 Dec 24;383(26):2557-2570
pubmed: 33369357
Oncogene. 2012 Jul 5;31(27):3223-34
pubmed: 22056872
Cancer. 2012 Oct 15;118(20):4929-35
pubmed: 22415862
Cancer Res. 2022 Apr 1;82(7):1321-1339
pubmed: 35078818
J Clin Oncol. 2008 Mar 1;26(7):1059-65
pubmed: 18227529
Mod Pathol. 2011 Jul;24(7):924-31
pubmed: 21552212
Sci Adv. 2016 Jun 24;2(6):e1501924
pubmed: 27386569
Biochim Biophys Acta Rev Cancer. 2019 Dec;1872(2):188315
pubmed: 31647985
Nat Med. 2021 Feb;27(2):310-320
pubmed: 33462444
Breast Cancer Res Treat. 1994;31(1):117-27
pubmed: 7981452
JAMA Oncol. 2016 Oct 01;2(10):1354-1360
pubmed: 27355489
Cancer Res. 2000 Dec 15;60(24):6890-4
pubmed: 11156387
J Clin Oncol. 2005 Apr 10;23(11):2469-76
pubmed: 15753463
Ther Adv Med Oncol. 2022 Mar 15;14:17588359221083956
pubmed: 35309087
Clin Cancer Res. 2017 Aug 15;23(16):4793-4804
pubmed: 28473534
Clin Cancer Res. 2019 Jan 1;25(1):277-289
pubmed: 30314968
J Pain Palliat Care Pharmacother. 2008;22(1):45-46
pubmed: 28792816
Mol Cancer Ther. 2021 Feb;20(2):250-262
pubmed: 33310762
J Clin Oncol. 2009 Sep 20;27(27):4530-5
pubmed: 19704066
Cancer Res. 2010 Mar 1;70(5):2085-94
pubmed: 20179196
Nat Cell Biol. 2001 Jan;3(1):15-23
pubmed: 11146621
J Biol Chem. 2006 Apr 7;281(14):9607-15
pubmed: 16459337
Cell Rep. 2018 Aug 7;24(6):1434-1444.e7
pubmed: 30089255
N Engl J Med. 2012 Feb 9;366(6):520-9
pubmed: 22149876
Clin Cancer Res. 2020 Feb 1;26(3):608-622
pubmed: 31591187
Nature. 2023 Jun;618(7963):144-150
pubmed: 37165196
JAMA Oncol. 2016 Oct 01;2(10):1310-1315
pubmed: 27532364
Clin Breast Cancer. 2022 Oct;22(7):642-649
pubmed: 35906130
Eur J Cancer Clin Oncol. 1983 May;19(5):615-21
pubmed: 6683633
Cancer Res. 1991 Aug 1;51(15):3867-73
pubmed: 1855205
Science. 2002 Mar 29;295(5564):2465-8
pubmed: 11923541
Mol Oncol. 2011 Feb;5(1):5-23
pubmed: 21147047
Cancers (Basel). 2022 Jan 09;14(2):
pubmed: 35053474
Lancet. 2011 Aug 27;378(9793):771-84
pubmed: 21802721
J Bone Miner Res. 1994 Aug;9(8):1251-8
pubmed: 7976507
Mol Cell Endocrinol. 2002 Jun 28;192(1-2):93-104
pubmed: 12088871
Ann Oncol. 2018 Apr 1;29(4):872-880
pubmed: 29360925
Genes Dev. 2006 Sep 15;20(18):2513-26
pubmed: 16980581
Endocr Relat Cancer. 2011 Aug 30;18(5):565-77
pubmed: 21734071
Nature. 2015 Jul 16;523(7560):313-7
pubmed: 26153859
Int J Mol Sci. 2021 Jul 22;22(15):
pubmed: 34360578
Explor Target Antitumor Ther. 2022;3(4):480-496
pubmed: 36071983
Ther Adv Med Oncol. 2018 Jul 17;10:1758835918786451
pubmed: 30038670
Nat Genet. 2019 Feb;51(2):207-216
pubmed: 30531871
PLoS One. 2018 Oct 10;13(10):e0204973
pubmed: 30304013
Int J Cancer. 2000 Mar 20;89(2):111-7
pubmed: 10754487
Expert Opin Investig Drugs. 2022 Jun;31(6):515-529
pubmed: 34694932