The impact of oocyte central granularity on ICSI practice: developmental competence of dysmorphic and morphologically normal companion oocytes.
Fertilization
Live birth
Maternal age
Morphokinetics
Oocyte central granularity
Journal
Journal of assisted reproduction and genetics
ISSN: 1573-7330
Titre abrégé: J Assist Reprod Genet
Pays: Netherlands
ID NLM: 9206495
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
13
03
2023
accepted:
18
07
2023
pmc-release:
01
10
2024
medline:
18
9
2023
pubmed:
28
7
2023
entrez:
27
7
2023
Statut:
ppublish
Résumé
To assess the effects of oocyte central granularity and its underlying endocrine environment on developmental competence of dysmorphic and morphologically normal oocytes. Retrospective cohort study including 1,082 patients undergoing autologous ICSI cycles. Of these, 211 patients provided 602 oocytes with central granularity (CG) and 427 morphologically normal cycle companion oocytes (NCG). The remaining 871 patients provided only morphologically normal oocytes in cycles not yielding dysmorphic oocytes (N). Patient profile associated with CG was characterized, and fertilization rates, early morphokinetics and live birth rates were compared between N, CG and NCG groups. Patient characteristics associated with implantation and delivery performance of CG-derived embryos were assessed. CG was associated with higher maternal age, basal FSH concentrations and total FSH dose, but with lower circulating AMH (p ≤ 0.035). Fertilization rates were reduced and early morphokinetic parameters were delayed in CG (p < 0.025) and NCG (p < 0.05) groups as compared to the N group. Embryos derived from CG oocytes achieved a markedly lower live birth rate (14.9%) as compared to those derived from NCG (36.8%; p = 0.03) and N oocytes (29.8%; p = 0.002). The negative relationship between CG and live birth was confirmed by a multivariate analysis controlling for potential confounders (OR:2.59, IC:1.27-5.31; P = 0.009). Implantation and delivery rates following transfers of CG-derived embryos were inversely associated with maternal age. CG oocytes, but not their morphologically normal cycle companions, have severely compromised developmental competence. Maternal age should be a key parameter in deciding whether or not to utilize CG oocytes in ICSI cycles.
Identifiants
pubmed: 37501005
doi: 10.1007/s10815-023-02895-9
pii: 10.1007/s10815-023-02895-9
pmc: PMC10504199
doi:
Substances chimiques
Follicle Stimulating Hormone
9002-68-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2375-2384Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Balaban B, Urman B, Sertac A, Alatas C, Aksoy S, Mercan R. Oocyte morphology does not affect fertilization rate, embryo quality and implantation rate after intracytoplasmic sperm injection. Hum Reprod. 1998;13:3431–3. https://doi.org/10.1093/humrep/13.12.3431 .
doi: 10.1093/humrep/13.12.3431
pubmed: 9886529
Ebner T, Moser M, Tews G. Is oocyte morphology prognostic of embryo developmental potential after ICSI? Reprod Biomed Online. 2006;12:507–12. https://doi.org/10.1016/S1472-6483(10)62006-8 .
doi: 10.1016/S1472-6483(10)62006-8
pubmed: 16740226
Rienzi L, Vajta G, Ubaldi F. Predictive value of oocyte morphology in human IVF: a systematic review of the literature. Hum Reprod Update. 2010;17:34–45. https://doi.org/10.1093/humupd/dmq029 .
doi: 10.1093/humupd/dmq029
pubmed: 20639518
pmcid: 3001337
Braga DP, Setti AS, Figueira Rde C, Machado RB, Iaconelli A Jr, Borges E Jr. Influence of oocyte dysmorphisms on blastocyst formation and quality. Fertil Steril. 2013;100:748–54. https://doi.org/10.1016/j.fertnstert.2013.05.021 .
doi: 10.1016/j.fertnstert.2013.05.021
pubmed: 23768986
Rienzi L, Balaban B, Ebner T, Mandelbaum J. The oocyte. Hum Reprod. 2012;27(Suppl 1):i2-21. https://doi.org/10.1093/humrep/des200 .
doi: 10.1093/humrep/des200
pubmed: 22811312
Dal Canto M, Guglielmo MC, Mignini Renzini M, Fadini R, Moutier C, Merola M, De Ponti E, Coticchio G. Dysmorphic patterns are associated with cytoskeletal alterations in human oocytes. Hum Reprod. 2017;32:750–7. https://doi.org/10.1093/humrep/dex041 .
doi: 10.1093/humrep/dex041
Hu J, Molinari E, Darmon S, Zhang L, Patrizio P, Barad DH, Gleicher N. Predictive value of cytoplasmic granulation patterns during in vitro fertilization in metaphase II oocytes: Part I, poor-prognosis patients. Fertil Steril. 2021;116:431–43. https://doi.org/10.1016/j.fertnstert.2021.02.022 .
doi: 10.1016/j.fertnstert.2021.02.022
pubmed: 33865566
Hu J, Molinari E, Darmon SK, Zhang L, Patrizio P, Barad DH, Gleicher N. Predictive value of cytoplasmic granulation patterns during in vitro fertilization in metaphase II oocytes: part II, donor oocyte cycles. Fertil Steril. 2021;116:1330–40. https://doi.org/10.1016/j.fertnstert.2021.06.026 .
doi: 10.1016/j.fertnstert.2021.06.026
pubmed: 34294452
Serhal PF, Ranieri DM, Kinis A, Marchant S, Davies M, Khadum IM. Oocyte morphology predicts outcome of intracytoplasmic sperm injection. Hum Reprod. 1997;12:1267–70. https://doi.org/10.1093/humrep/12.6.1267 .
doi: 10.1093/humrep/12.6.1267
pubmed: 9222015
Kahraman S, Yakın K, Dönmez E, Samlı H, Bahce M, Cengiz G, Sertyel S, Samlı M, İmirzalıoğlu N. Relationship between granular cytoplasm of oocytes and pregnancy outcome following intracytoplasmic sperm injection. Hum Reprod. 2000;15:2390–3. https://doi.org/10.1093/humrep/15.11.2390 .
doi: 10.1093/humrep/15.11.2390
pubmed: 11056140
Rienzi L, Ubaldi FM, Iacobelli M, Minasi MG, Romano S, Ferrero S, Sapienza F, Baroni E, Litwicka K, Greco E. Significance of metaphase II human oocyte morphology on ICSI outcome. Fertil Steril. 2008;90:1692–700. https://doi.org/10.1016/j.fertnstert.2007.09.024 .
doi: 10.1016/j.fertnstert.2007.09.024
pubmed: 18249393
Lemmen JG, Agerholm I, Ziebe S. Kinetic markers of human embryo quality using time-lapse recordings of IVF/ICSI-fertilized oocytes. Reprod Biomed Online. 2008;17:385–91. https://doi.org/10.1016/S1472-6483(10)60222-2 .
doi: 10.1016/S1472-6483(10)60222-2
pubmed: 18765009
Armstrong S, Bhide P, Jordan V, Pacey A, Marjoribanks J, Farquhar C. Time-lapse systems for embryo incubation and assessment in assisted reproduction. Cochrane Database Syst Rev. 2019;5:1–69. https://doi.org/10.1002/14651858.CD011320.pub4 .
doi: 10.1002/14651858.CD011320.pub4
Bartolacci A, Buratini J, Moutier C, Guglielmo MC, Novara PV, Brambillasca F, Renzini MM, Dal Canto M. Maternal body mass index affects embryo morphokinetics: a time-lapse study. J Assist Reprod Genet. 2019;36:1109–16. https://doi.org/10.1007/s10815-019-01456-3 .
doi: 10.1007/s10815-019-01456-3
pubmed: 31062218
pmcid: 6603074
Del Gallego R, Remohi J, Meseguer M. Time-lapse imaging: the state of the artdagger. Biol Reprod. 2019;101:1146–54. https://doi.org/10.1093/biolre/ioz035 .
doi: 10.1093/biolre/ioz035
pubmed: 30810735
Dal Canto M, Bartolacci A, Turchi D, Pignataro D, Lain M, De Ponti E, Brigante C, Mignini Renzini M, Buratini J. Faster fertilization and cleavage kinetics reflect competence to achieve a live birth after intracytoplasmic sperm injection, but this association fades with maternal age. Fertil Steril. 2020. https://doi.org/10.1016/j.fertnstert.2020.06.023 .
doi: 10.1016/j.fertnstert.2020.06.023
Siristatidis C, Komitopoulou MA, Makris A, Sialakouma A, Botzaki M, Mastorakos G, Salamalekis G, Bettocchi S, Palmer GA. Morphokinetic parameters of early embryo development via time lapse monitoring and their effect on embryo selection and ICSI outcomes: a prospective cohort study. J Assist Reprod Genet. 2015;32:563–70. https://doi.org/10.1007/s10815-015-0436-z .
doi: 10.1007/s10815-015-0436-z
pubmed: 25617087
pmcid: 4380900
Fishel S, Campbell A, Montgomery S, Smith R, Nice L, Duffy S, Jenner L, Berrisford K, Kellam L, Smith R. Time-lapse imaging algorithms rank human preimplantation embryos according to the probability of live birth. Reprod Biomed Online. 2018;37:304–13. https://doi.org/10.1016/j.rbmo.2018.05.016 .
doi: 10.1016/j.rbmo.2018.05.016
pubmed: 30314885
Bartolacci A, Dal Canto M, Guglielmo MC, Mura L, Brigante C, Renzini MM, Buratini J. Early embryo morphokinetics is a better predictor of post-ICSI live birth than embryo morphology: speed is more important than beauty at the cleavage stage. Zygote. 2021;29:495–502. https://doi.org/10.1017/S0967199421000253 .
doi: 10.1017/S0967199421000253
pubmed: 33910671
ALPHA Scientists In Reproductive Medicine, ESHRE Special Interest Group Embryology. Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Reprod Biomed Online. 2011;22:632–46. https://doi.org/10.1016/j.rbmo.2011.02.001 .
doi: 10.1016/j.rbmo.2011.02.001
Practice Committee of American Society for Reproductive Medicine, Practice Committee of Society for Assisted Reproductive Technology. Criteria for number of embryos to transfer: a committee opinion. Fertil Steril. 2013;99:44–6. https://doi.org/10.1016/j.fertnstert.2012.09.038 .
doi: 10.1016/j.fertnstert.2012.09.038
Buratini J, Dal Canto M, De Ponti E, Brambillasca F, Brigante C, Gippone S, Mignini Renzini M, La Marca A. Maternal age affects the relationship of basal FSH and anti-Mullerian hormone concentrations with post-ICSI/IVF live birth. Reprod Biomed Online. 2021. https://doi.org/10.1016/j.rbmo.2020.12.005 .
doi: 10.1016/j.rbmo.2020.12.005
pubmed: 33653653
Buratini J, Dellaqua TT, Dal Canto M, La Marca A, Carone D, Mignini Renzini M, Webb R. The putative roles of FSH and AMH in the regulation of oocyte developmental competence: from fertility prognosis to mechanisms underlying age-related subfertility. Hum Reprod Update. 2021;28:232–54. https://doi.org/10.1093/humupd/dmab044 .
doi: 10.1093/humupd/dmab044
Lin Y, Yang P, Chen Y, Zhu J, Zhang X, Ma C. Factors inducing decreased oocyte maturation rate: a retrospective analysis of 20,939 ICSI cycles. Arch Gynecol Obstet. 2019;299:559–64. https://doi.org/10.1007/s00404-018-4958-3 .
doi: 10.1007/s00404-018-4958-3
pubmed: 30607580
Pellatt L, Rice S, Dilaver N, Heshri A, Galea R, Brincat M, Brown K, Simpson ER, Mason HD. Anti-Mullerian hormone reduces follicle sensitivity to follicle-stimulating hormone in human granulosa cells. Fertil Steril. 2011;96:1246–51. https://doi.org/10.1016/j.fertnstert.2011.08.015 .
doi: 10.1016/j.fertnstert.2011.08.015
pubmed: 21917251
Chang HM, Klausen C, Leung PC. Antimullerian hormone inhibits follicle-stimulating hormone-induced adenylyl cyclase activation, aromatase expression, and estradiol production in human granulosa-lutein cells. Fertil Steril. 2013;100:585–92. https://doi.org/10.1016/j.fertnstert.2013.04.019 .
doi: 10.1016/j.fertnstert.2013.04.019
pubmed: 23663993
Ciepiela P, Duleba AJ, Kario A, Chelstowski K, Branecka-Wozniak D, Kurzawa R. Oocyte matched follicular fluid anti-Mullerian hormone is an excellent predictor of live birth after fresh single embryo transfer. Hum Reprod. 2019;34:2244–53. https://doi.org/10.1093/humrep/dez186 .
doi: 10.1093/humrep/dez186
pubmed: 31725884
Ebner T, Moser M, Shebl O, Sommerguber M, Tews G. Prognosis of oocytes showing aggregation of smooth endoplasmic reticulum. Reprod Biomed Online. 2008;16:113–8. https://doi.org/10.1016/S1472-6483(10)60563-9 .
doi: 10.1016/S1472-6483(10)60563-9
pubmed: 18252056
Combelles CM, Carabatsos MJ, Kumar TR, Matzuk MM, Albertini DF. Hormonal control of somatic cell oocyte interactions during ovarian follicle development. Mol Reprod Dev. 2004;69:347–55. https://doi.org/10.1002/mrd.20128 .
doi: 10.1002/mrd.20128
pubmed: 15349847
Macaulay AD, Gilbert I, Scantland S, Fournier E, Ashkar F, Bastien A, Saadi HA, Gagne D, Sirard MA, Khandjian EW, et al. Cumulus cell transcripts transit to the bovine oocyte in preparation for maturation. Biol Reprod. 2016;94:16. https://doi.org/10.1095/biolreprod.114.127571 .
doi: 10.1095/biolreprod.114.127571
pubmed: 26586844
Macaulay AD, Gilbert I, Caballero J, Barreto R, Fournier E, Tossou P, Sirard MA, Clarke HJ, Khandjian EW, Richard FJ, et al. The gametic synapse: RNA transfer to the bovine oocyte. Biol Reprod. 2014;91:90. https://doi.org/10.1095/biolreprod.114.119867 .
doi: 10.1095/biolreprod.114.119867
pubmed: 25143353
Alviggi C, Andersen CY, Buehler K, Conforti A, De Placido G, Esteves SC, Fischer R, Galliano D, Polyzos NP, Sunkara SK, et al. A new more detailed stratification of low responders to ovarian stimulation: from a poor ovarian response to a low prognosis concept. Fertil Steril. 2016;105:1452–3. https://doi.org/10.1016/j.fertnstert.2016.02.005 .
doi: 10.1016/j.fertnstert.2016.02.005
pubmed: 26921622