Keratoconus International Consortium (KIC)- advancing keratoconus research.
Consortium
Keratoconus
Keratoconus progression and treatment
Multi-centre project
Journal
BMC ophthalmology
ISSN: 1471-2415
Titre abrégé: BMC Ophthalmol
Pays: England
ID NLM: 100967802
Informations de publication
Date de publication:
27 Jul 2023
27 Jul 2023
Historique:
received:
19
09
2022
accepted:
16
07
2023
medline:
31
7
2023
pubmed:
28
7
2023
entrez:
27
7
2023
Statut:
epublish
Résumé
The Keratoconus International Consortium (KIC) will allow better understanding of keratoconus. Keratoconus is a disorder characterised by corneal elevation and thinning, leading to reduced vision. The current gaps in understanding of this disease will be discussed and the need for a multi-pronged and multi-centre engagement to enhance our understanding of keratoconus will be highlighted. KIC has been established to address the gaps in our understanding of keratoconus with the aim of collecting baseline as well as longitudinal data on several fields. Keratoconus and control (no corneal condition) subjects from different sites globally will be recruited in the study. KIC collects data using an online, secure database, which enables standardised data collection at member sites. Data fields collected include medical history, clinical features, quality of life and economic burden questionnaires and possible genetic sample collection from patients of different ethnicities across different geographical locations. There are currently 40 Australian and international clinics or hospital departments who have joined the KIC. Baseline data has so far been collected on 1130 keratoconus patients and indicates a median age of 29.70 years with 61% being male. A total of 15.3% report a positive family history of keratoconus and 57.7% self-report a history of frequent eye rubbing. The strength of this consortium is its international, collaborative design and use of a common data collection tool. Inclusion and analyses of cross-sectional and longitudinal data will help answer many questions that remain in keratoconus, including factors affecting progression and treatment outcomes.
Sections du résumé
CLINICAL RELEVANCE
CONCLUSIONS
The Keratoconus International Consortium (KIC) will allow better understanding of keratoconus.
BACKGROUND
BACKGROUND
Keratoconus is a disorder characterised by corneal elevation and thinning, leading to reduced vision. The current gaps in understanding of this disease will be discussed and the need for a multi-pronged and multi-centre engagement to enhance our understanding of keratoconus will be highlighted.
DESIGN
METHODS
KIC has been established to address the gaps in our understanding of keratoconus with the aim of collecting baseline as well as longitudinal data on several fields.
PARTICIPANTS
METHODS
Keratoconus and control (no corneal condition) subjects from different sites globally will be recruited in the study.
METHODS
METHODS
KIC collects data using an online, secure database, which enables standardised data collection at member sites. Data fields collected include medical history, clinical features, quality of life and economic burden questionnaires and possible genetic sample collection from patients of different ethnicities across different geographical locations.
RESULTS
RESULTS
There are currently 40 Australian and international clinics or hospital departments who have joined the KIC. Baseline data has so far been collected on 1130 keratoconus patients and indicates a median age of 29.70 years with 61% being male. A total of 15.3% report a positive family history of keratoconus and 57.7% self-report a history of frequent eye rubbing.
CONCLUSION
CONCLUSIONS
The strength of this consortium is its international, collaborative design and use of a common data collection tool. Inclusion and analyses of cross-sectional and longitudinal data will help answer many questions that remain in keratoconus, including factors affecting progression and treatment outcomes.
Identifiants
pubmed: 37501133
doi: 10.1186/s12886-023-03087-w
pii: 10.1186/s12886-023-03087-w
pmc: PMC10375634
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
337Subventions
Organisme : Australian National Health and Medical Research Council
ID : APP1187763
Organisme : NHMRC Senior Research Fellowship
ID : 1138585
Investigateurs
Christopher Hodge
(C)
Elaine W Chong
(EW)
Faouzia Zemani-Fodil
(F)
Steve Wiffen
(S)
Grant Snibson
(G)
Nigel Morlet
(N)
Chameen Samarawickrama
(C)
John Males
(J)
Richard Mills
(R)
Peter Beckingsale
(P)
Kathryn Burdon
(K)
Vishal Jhanji
(V)
Pravin Krishna
(P)
Colin Chan
(C)
Abi Tenen
(A)
Athena Roufas
(A)
Tess Huynh
(T)
Rasik Vajpayee
(R)
Aanchal Gupta
(A)
Marcelo Reyes Silva
(MR)
Mehran Zarei
(M)
Senthil Kumaran
(S)
Guofu Huang
(G)
Berthold Seitz
(B)
Shengwei Ren
(S)
Charles McGhee
(C)
Nigel Barker
(N)
Informations de copyright
© 2023. The Author(s).
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