Screening for Antibody Deficiencies in Adults by Serum Electrophoresis and Calculated Globin.
Antibody deficiency
adults
calculated globulin
gamma globulin fraction
immunoglobulin G
protein electrophoresis
Journal
Journal of clinical immunology
ISSN: 1573-2592
Titre abrégé: J Clin Immunol
Pays: Netherlands
ID NLM: 8102137
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
03
03
2023
accepted:
09
06
2023
medline:
21
11
2023
pubmed:
28
7
2023
entrez:
28
7
2023
Statut:
ppublish
Résumé
This study aimed to investigate the correlation between calculated globulin (CG, total protein level minus albumin level) and the gamma globulin fraction (Gamma), obtained from serum protein electrophoresis with serum IgG levels in adults (≥ 18 years). Using linear regression models, analyses of CG and Gamma levels correlation with IgG levels in adults were performed. Receiver-operator curves were created to determine cutoff values and the respective sensitivity and specificity measures. A total of 886 samples were analyzed. CG and Gamma were positively and statistically correlated with IgG levels (r Both CG and Gamma levels determined by protein electrophoresis analysis may be used to screen for antibody deficiencies in adults, enabling earlier diagnosis of antibody deficiencies in a routine clinical setting.
Identifiants
pubmed: 37505322
doi: 10.1007/s10875-023-01536-1
pii: 10.1007/s10875-023-01536-1
doi:
Substances chimiques
Globins
9004-22-2
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1873-1880Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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