Plasmin-Mediated Fibrinolysis in Periodontitis Pathogenesis.
extracellular matrix (ECM)
fibrin
immunity
inflammation
plasminogen
proteases/proteinases
Journal
Journal of dental research
ISSN: 1544-0591
Titre abrégé: J Dent Res
Pays: United States
ID NLM: 0354343
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
pmc-release:
01
08
2024
medline:
7
8
2023
pubmed:
28
7
2023
entrez:
28
7
2023
Statut:
ppublish
Résumé
The hemostatic and inflammatory systems work hand in hand to maintain homeostasis at mucosal barrier sites. Among the factors of the hemostatic system, fibrin is well recognized for its role in mucosal homeostasis, wound healing, and inflammation. Here, we present a basic overview of the fibrinolytic system, discuss fibrin as an innate immune regulator, and provide recent work uncovering the role of fibrin-neutrophil activation as a regulator of mucosal/periodontal homeostasis. We reason that the role of fibrin in periodontitis becomes most evident in individuals with the Mendelian genetic defect, congenital plasminogen (PLG) deficiency, who are predisposed to severe periodontitis in childhood due to a defect in fibrinolysis. Consistent with plasminogen deficiency being a risk factor for periodontitis, recent genomics studies uncover genetic polymorphisms in
Identifiants
pubmed: 37506226
doi: 10.1177/00220345231171837
pmc: PMC10477773
doi:
Substances chimiques
Fibrinolysin
EC 3.4.21.7
Plasminogen
9001-91-6
Fibrin
9001-31-4
Hemostatics
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
972-978Subventions
Organisme : NIDCR NIH HHS
ID : R00 DE030124
Pays : United States
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