Therapeutic Targeting of RNA Splicing in Cancer.
alternative splicing
anti-sense oligonucleotides
immuno-oncology therapies
spliceosome inhibitors
splicing factor mutations
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
29 06 2023
29 06 2023
Historique:
received:
06
06
2023
revised:
25
06
2023
accepted:
27
06
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
RNA splicing is a key regulatory step in the proper control of gene expression. It is a highly dynamic process orchestrated by the spliceosome, a macro-molecular machinery that consists of protein and RNA components. The dysregulation of RNA splicing has been observed in many human pathologies ranging from neurodegenerative diseases to cancer. The recent identification of recurrent mutations in the core components of the spliceosome in hematologic malignancies has advanced our knowledge of how splicing alterations contribute to disease pathogenesis. This review article will discuss our current understanding of how aberrant RNA splicing regulation drives tumor initiation and progression. We will also review current therapeutic modalities and highlight emerging technologies designed to target RNA splicing for cancer treatment.
Identifiants
pubmed: 37510283
pii: genes14071378
doi: 10.3390/genes14071378
pmc: PMC10379351
pii:
doi:
Substances chimiques
RNA Splicing Factors
0
RNA
63231-63-0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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