Calpain Regulation and Dysregulation-Its Effects on the Intercalated Disk.
adherens junction
calpain
calpastatin
desmosome
gap junction
heart
intercalated disc
intercalated disk
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Jul 2023
21 Jul 2023
Historique:
received:
30
06
2023
revised:
12
07
2023
accepted:
17
07
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
The intercalated disk is a cardiac specific structure composed of three main protein complexes-adherens junctions, desmosomes, and gap junctions-that work in concert to provide mechanical stability and electrical synchronization to the heart. Each substructure is regulated through a variety of mechanisms including proteolysis. Calpain proteases, a class of cysteine proteases dependent on calcium for activation, have recently emerged as important regulators of individual intercalated disk components. In this review, we will examine how calcium homeostasis regulates normal calpain function. We will also explore how calpains modulate gap junctions, desmosomes, and adherens junctions activity by targeting specific proteins, and describe the molecular mechanisms of how calpain dysregulation leads to structural and signaling defects within the heart. We will then examine how changes in calpain activity affects cardiomyocytes, and how such changes underlie various heart diseases.
Identifiants
pubmed: 37511485
pii: ijms241411726
doi: 10.3390/ijms241411726
pmc: PMC10380737
pii:
doi:
Substances chimiques
Calpain
EC 3.4.22.-
Calcium
SY7Q814VUP
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R15 GM148890
Pays : United States
Organisme : NASA
ID : Pennsylvania Space Grant Consortium
Pays : United States
Organisme : NIH HHS
ID : R15GM148890
Pays : United States
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