Transient Receptor Potential Ankyrin 1 (TRPA1) Channel Mediates Acrolein Cytotoxicity in Human Lung Cancer Cells.
acrolein
cell damage
cytotoxicity
transient receptor potential ankyrin 1 (TRPA1)
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Jul 2023
24 Jul 2023
Historique:
received:
26
06
2023
revised:
22
07
2023
accepted:
23
07
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective ion channel implicated in thermosensation and inflammatory pain. It has been reported that expression of the TRPA1 channel is induced by cigarette smoke extract. Acrolein found in cigarette smoke is highly toxic and known as an agonist of the TRPA1 channel. However, the role of TRPA1 in the cytotoxicity of acrolein remains unclear. Here, we investigated whether the TRPA1 channel is involved in the cytotoxicity of acrolein in human lung cancer A549 cells. The IC
Identifiants
pubmed: 37511605
pii: ijms241411847
doi: 10.3390/ijms241411847
pmc: PMC10380761
pii:
doi:
Substances chimiques
Transient Receptor Potential Channels
0
Acrolein
7864XYD3JJ
TRPA1 Cation Channel
0
Ankyrins
0
Cytoskeletal Proteins
0
TRPA1 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 21K15258
Organisme : Japan Society for the Promotion of Science
ID : 21K06714
Organisme : Smoking Research Foundation
ID : 2018Y009
Références
Cell. 2003 Mar 21;112(6):819-29
pubmed: 12654248
Int J Biochem Cell Biol. 2019 Aug;113:58-66
pubmed: 31150838
Physiol Rev. 2020 Apr 1;100(2):725-803
pubmed: 31670612
Mol Nutr Food Res. 2008 Jan;52(1):7-25
pubmed: 18203133
J Bacteriol. 1986 Apr;166(1):128-34
pubmed: 3514574
Future Sci OA. 2019 May 03;5(5):FSO394
pubmed: 31205749
Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2383-8
pubmed: 23345429
Free Radic Biol Med. 2019 Apr;134:229-238
pubmed: 30639616
J Biol Chem. 2012 Aug 17;287(34):28291-306
pubmed: 22740698
Toxicol Sci. 2015 Feb;143(2):242-55
pubmed: 25628402
Front Immunol. 2018 Sep 27;9:2160
pubmed: 30319623
Atherosclerosis. 2016 Jan;244:131-7
pubmed: 26630182
Biochem Biophys Res Commun. 2012 Feb 3;418(1):110-5
pubmed: 22244891
J Biol Chem. 2018 Nov 30;293(48):18736-18745
pubmed: 30333229
Pulm Pharmacol Ther. 2021 Oct;70:102059
pubmed: 34302984
Biochem Biophys Res Commun. 2013 Jan 25;430(4):1265-71
pubmed: 23261472
Biomolecules. 2023 Feb 04;13(2):
pubmed: 36830667
Cell. 2006 Mar 24;124(6):1269-82
pubmed: 16564016
Cell Death Dis. 2020 Aug 15;11(8):633
pubmed: 32801314
Mol Nutr Food Res. 2011 Sep;55(9):1332-41
pubmed: 21732531
Sci Rep. 2016 Sep 29;6:34424
pubmed: 27680676
Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19564-8
pubmed: 17164327
Stroke. 2005 Dec;36(12):2609-13
pubmed: 16269634
Amino Acids. 2021 Oct;53(10):1473-1492
pubmed: 34546444
Nature. 2007 Feb 1;445(7127):541-5
pubmed: 17237762
Mediators Inflamm. 2015;2015:148367
pubmed: 26504357
Cancer Cell. 2018 Jun 11;33(6):985-1003.e7
pubmed: 29805077
J Recept Signal Transduct Res. 2011 Oct;31(5):350-8
pubmed: 21848366
Cytoskeleton (Hoboken). 2020 Oct;77(10):414-421
pubmed: 33070462
Int J Mol Sci. 2022 Apr 20;23(9):
pubmed: 35562920
J Biol Chem. 2012 Sep 14;287(38):31962-72
pubmed: 22843691
Chem Res Toxicol. 2013 Dec 16;26(12):1782-800
pubmed: 24224555
Free Radic Biol Med. 2016 Oct;99:498-507
pubmed: 27480844
Pharmaceuticals (Basel). 2018 Sep 21;11(4):
pubmed: 30248976
Free Radic Biol Med. 2014 Jul;72:200-9
pubmed: 24780252
J Biol Chem. 1999 Mar 12;274(11):7325-33
pubmed: 10066796
Biochem Biophys Res Commun. 2017 Aug 26;490(3):587-593
pubmed: 28629997
J Inflamm Res. 2020 Dec 02;13:1057-1073
pubmed: 33293849
Oncotarget. 2019 Dec 17;10(66):7071-7079
pubmed: 31903166
Cells. 2023 Mar 11;12(6):
pubmed: 36980220