The Molecular Role of Immune Cells in Dilated Cardiomyopathy.
cytokines
dilated cardiomyopathy
immune cells
immunotherapy
Journal
Medicina (Kaunas, Lithuania)
ISSN: 1648-9144
Titre abrégé: Medicina (Kaunas)
Pays: Switzerland
ID NLM: 9425208
Informations de publication
Date de publication:
05 Jul 2023
05 Jul 2023
Historique:
received:
31
05
2023
revised:
29
06
2023
accepted:
03
07
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
Dilated cardiomyopathy (DCM) is a rare and severe condition characterized by chamber dilation and impaired contraction of the left ventricle. It constitutes a fundamental etiology for profound heart failure and abrupt cardiac demise, rendering it a prominent clinical indication for heart transplantation (HTx) among both adult and pediatric populations. DCM arises from various etiologies, including genetic variants, epigenetic disorders, infectious insults, autoimmune diseases, and cardiac conduction abnormalities. The maintenance of cardiac function involves two distinct types of immune cells: resident immune cells and recruited immune cells. Resident immune cells play a crucial role in establishing a harmonious microenvironment within the cardiac tissue. Nevertheless, in response to injury, cardiomyocytes initiate a cytokine cascade that attracts peripheral immune cells, thus perturbing this intricate equilibrium and actively participating in the initiation and pathological remodeling of dilated cardiomyopathy (DCM), particularly during the progression of myocardial fibrosis. Additionally, immune cells assume a pivotal role in orchestrating the inflammatory processes, which are intimately linked to the prognosis of DCM. Consequently, understanding the molecular role of various immune cells and their regulation mechanisms would provide an emerging era for managing DCM. In this review, we provide a summary of the most recent advancements in our understanding of the molecular mechanisms of immune cells in DCM. Additionally, we evaluate the effectiveness and limitations of immunotherapy approaches for the treatment of DCM, with the aim of optimizing future immunotherapeutic strategies for this condition.
Identifiants
pubmed: 37512058
pii: medicina59071246
doi: 10.3390/medicina59071246
pmc: PMC10385992
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Technology Project of Sichuan Province of China
ID : 2021YFQ0061
Organisme : National Natural Science Foundation of China
ID : 82270249
Références
J Exp Med. 2009 Mar 16;206(3):497-505
pubmed: 19221394
Eur J Cardiothorac Surg. 2005 Jan;27(1):122-7
pubmed: 15621483
Scand J Immunol. 2013 Jan;77(1):54-61
pubmed: 22998220
J Immunol. 2001 Nov 1;167(9):5464-9
pubmed: 11673566
Circulation. 2014 May 27;129(21):2111-24
pubmed: 24657994
Tohoku J Exp Med. 1988 Apr;154(4):335-44
pubmed: 3263716
Virol J. 2014 Dec 30;11:230
pubmed: 25547181
BMC Cardiovasc Disord. 2022 Mar 4;22(1):78
pubmed: 35246021
Immunity. 2015 Jul 21;43(1):161-74
pubmed: 26092469
Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):180-5
pubmed: 15611472
J Am Coll Cardiol. 2000 May;35(6):1590-8
pubmed: 10807465
Braz J Med Biol Res. 2021 Oct 18;54(12):e11232
pubmed: 34669781
Hypertension. 2014 Apr;63(4):797-803
pubmed: 24420551
Int Arch Allergy Immunol. 2012;157(4):406-16
pubmed: 22123224
Circ Res. 2021 May 28;128(11):1766-1779
pubmed: 34043424
Heart. 1996 Mar;75(3):295-300
pubmed: 8800996
Circulation. 2020 Jul 28;142(4):384-400
pubmed: 32431172
J Immunol. 2004 May 1;172(9):5149-53
pubmed: 15100250
Front Immunol. 2018 Aug 13;9:1869
pubmed: 30150991
Autoimmunity. 2008 Sep;41(6):490-9
pubmed: 18781477
Blood. 2012 Aug 9;120(6):1237-45
pubmed: 22760781
Cytokine. 1998 Oct;10(10):739-46
pubmed: 9811526
Atheroscler Suppl. 2017 Nov;30:257-263
pubmed: 29096847
Herz. 2012 Sep;37(6):644-56
pubmed: 22996288
Blood. 2004 Dec 15;104(13):4071-9
pubmed: 15328161
Herz. 2000 May;25(3):279-85
pubmed: 10904853
Heart. 2010 May;96(10):765-71
pubmed: 20448127
Annu Rev Immunol. 2021 Apr 26;39:51-76
pubmed: 33428453
Circ Res. 2014 Jul 7;115(2):284-95
pubmed: 24786973
Int J Cardiol. 2009 Jan 9;131(2):246-56
pubmed: 18243370
Mol Cell Biochem. 2008 Jan;307(1-2):159-67
pubmed: 17849172
Nat Rev Cardiol. 2020 Jun;17(6):327-340
pubmed: 31996800
Eur Heart J. 2009 May;30(10):1229-36
pubmed: 19329498
Circulation. 2011 Nov 8;124(19):2106-16
pubmed: 22025605
Circ Heart Fail. 2017 Mar;10(3):e003688
pubmed: 28242779
Circulation. 2007 Apr 3;115(13):1747-53
pubmed: 17372175
Immunology. 2022 Sep;167(1):40-53
pubmed: 35502635
Am Heart J. 2006 Oct;152(4):712.e1-6
pubmed: 16996843
Eur J Heart Fail. 2017 Nov;19(11):1379-1389
pubmed: 28891154
JAMA. 2006 Oct 18;296(15):1867-76
pubmed: 17047217
J Immunol. 2013 Jan 1;190(1):3-4
pubmed: 23264668
Tohoku J Exp Med. 1992 Nov;168(3):529-37
pubmed: 1284796
Inflammation. 2019 Jun;42(3):953-960
pubmed: 30604194
Curr Opin Cardiol. 2021 May 1;36(3):288-294
pubmed: 33769382
Cell Mol Life Sci. 2014 Feb;71(4):549-74
pubmed: 23649149
J Exp Med. 2017 Nov 6;214(11):3311-3329
pubmed: 28970239
J Am Coll Cardiol. 2001 Feb;37(2):418-24
pubmed: 11216956
Front Physiol. 2015 Apr 07;6:107
pubmed: 25904868
Nat Rev Immunol. 2018 Dec;18(12):733-744
pubmed: 30228378
Heart Lung Circ. 2020 Apr;29(4):566-574
pubmed: 31974027
Basic Res Cardiol. 2021 Jan 11;116(1):1
pubmed: 33432417
Circ Res. 2015 Mar 27;116(7):1254-68
pubmed: 25814686
Antivir Ther. 2010;15(2):193-201
pubmed: 20386074
Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3356-65
pubmed: 17921324
J Intern Med. 2023 Jan;293(1):23-47
pubmed: 36030368
J Proteomics. 2017 Jan 6;150:121-129
pubmed: 27616206
J Immunol Res. 2018 Jun 21;2018:4396351
pubmed: 30035131
Am J Physiol. 1999 Jul;277(1):H253-60
pubmed: 10409204
Circ Heart Fail. 2013 Sep 1;6(5):913-21
pubmed: 23888044
Atheroscler Suppl. 2015 May;18:124-33
pubmed: 25936316
Immunobiology. 2012 May;217(5):468-75
pubmed: 21820754
Circ Res. 2016 Jun 24;119(1):91-112
pubmed: 27340270
Circulation. 2019 Oct 29;140(18):1491-1505
pubmed: 31533459
Adv Exp Med Biol. 2020;1254:1-22
pubmed: 32323265
Br J Pharmacol. 2017 Nov;174(22):3914-3925
pubmed: 27590129
Immunity. 2003 Jul;19(1):71-82
pubmed: 12871640
J Heart Lung Transplant. 1997 Dec;16(12):1248-54
pubmed: 9436137
J Biol Chem. 2005 Oct 28;280(43):36099-109
pubmed: 16141211
Adv Exp Med Biol. 2017;1003:187-221
pubmed: 28667560
Biomedicines. 2023 Feb 11;11(2):
pubmed: 36831060
Atheroscler Suppl. 2013 Jan;14(1):185-9
pubmed: 23357163
Heart. 2009 Sep;95(17):1409-14
pubmed: 19443476
Autoimmunity. 2008 Sep;41(6):484-9
pubmed: 18781476
J Am Coll Cardiol. 2002 Jan 16;39(2):241-6
pubmed: 11788214
Basic Res Cardiol. 2016 Sep;111(5):53
pubmed: 27412778
Immunology. 2018 Mar;153(3):290-296
pubmed: 29106696
J Am Coll Cardiol. 2017 Feb 7;69(5):526-537
pubmed: 27856208
Am Heart J. 2006 Oct;152(4):697-704
pubmed: 16996841
Basic Res Cardiol. 2019 Aug 15;114(5):37
pubmed: 31418072
Circ Res. 2010 May 28;106(10):1646-55
pubmed: 20378858
Am J Pathol. 2008 May;172(5):1195-208
pubmed: 18403598
Curr Opin Genet Dev. 2016 Jun;38:8-15
pubmed: 27003723
Heart Fail Rev. 2019 May;24(3):315-323
pubmed: 30612215
Lancet. 2017 Jul 22;390(10092):400-414
pubmed: 28190577
Eur J Heart Fail. 2019 May;21(5):553-576
pubmed: 30989768
Front Cardiovasc Med. 2019 Mar 18;6:25
pubmed: 30937305
Cells. 2020 Dec 31;10(1):
pubmed: 33396359
Cell. 2008 May 30;133(5):775-87
pubmed: 18510923
Heart Fail Rev. 2022 Jul;27(4):1173-1191
pubmed: 34263412
Circ Res. 2019 Jan 18;124(2):263-278
pubmed: 30582448
Indian Pediatr. 2014 Jul;51(7):583-4
pubmed: 25031145
Immunol Rev. 2011 Sep;243(1):191-205
pubmed: 21884177
Can J Cardiol. 2022 Apr;38(4):427-438
pubmed: 35032619
Cell Mol Life Sci. 2019 Feb;76(4):699-728
pubmed: 30377700
Int J Clin Exp Pathol. 2015 Jul 01;8(7):8107-14
pubmed: 26339378
Pflugers Arch. 2017 Apr;469(3-4):365-374
pubmed: 28185068
J Clin Invest. 2013 Feb;123(2):540-1
pubmed: 23485580
J Atheroscler Thromb. 2009 Aug;16(4):419-30
pubmed: 19729864
Mol Med Rep. 2014 Jul;10(1):359-64
pubmed: 24737285
J Am Heart Assoc. 2018 Jul 12;7(14):
pubmed: 30005555
Orphanet J Rare Dis. 2006 Jul 13;1:27
pubmed: 16839424
Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16029-34
pubmed: 25349429
Ann N Y Acad Sci. 2013 May;1285:80-96
pubmed: 23692566
Cardiovasc Res. 2021 May 25;117(6):1450-1488
pubmed: 33135058
Am J Pathol. 2001 Jul;159(1):193-203
pubmed: 11438466
Lancet. 1994 Sep 17;344(8925):773-7
pubmed: 7916071
Immunity. 2016 Oct 18;45(4):719-736
pubmed: 27760337
Scand Cardiovasc J. 2014 Aug;48(4):202-8
pubmed: 24912526
J Clin Immunol. 2010 Mar;30(2):226-34
pubmed: 20012175
Stem Cell Res Ther. 2017 Jan 28;8(1):18
pubmed: 28129792
Nat Rev Cardiol. 2016 Mar;13(3):167-79
pubmed: 26525543
J Autoimmun. 2013 Feb;40:45-57
pubmed: 22939403
Nat Rev Immunol. 2015 Feb;15(2):117-29
pubmed: 25614321
Am J Pathol. 2015 Mar;185(3):847-61
pubmed: 25622543
J Am Coll Cardiol. 2000 Jul;36(1):122-9
pubmed: 10898423
Cardiol Young. 2018 Jan;28(1):46-54
pubmed: 28797313
Transplant Proc. 2019 Apr;51(3):936-941
pubmed: 30979486
Semin Cell Dev Biol. 2015 May;41:49-58
pubmed: 24747368
Circulation. 2007 Jul 24;116(4):399-410
pubmed: 17620508
Ther Apher Dial. 2008 Apr;12(2):109-16
pubmed: 18387158
Vet Pathol. 2020 May;57(3):397-408
pubmed: 32125251
Front Immunol. 2021 Feb 19;12:616853
pubmed: 33679757
Cell Immunol. 2010;263(2):224-9
pubmed: 20435301
Front Immunol. 2017 Nov 03;8:1460
pubmed: 29163527
JCI Insight. 2016 Jun 16;1(9):
pubmed: 27366791
Circulation. 1997 Apr 15;95(8):1994-7
pubmed: 9133505
Circ Res. 2012 Jan 6;110(1):159-73
pubmed: 22223212
Int J Mol Sci. 2020 Sep 04;21(18):
pubmed: 32899712
Mol Med Rep. 2018 Jan;17(1):71-78
pubmed: 29115435
Immunity. 2022 Sep 13;55(9):1549-1563
pubmed: 36103852
Hypertension. 2017 Dec;70(6):1148-1156
pubmed: 29061727
Transfus Clin Biol. 2003 Jun;10(3):165-9
pubmed: 12798851
Curr Opin Cardiol. 1996 May;11(3):332-6
pubmed: 8835876
J Intern Med. 2019 Oct;286(4):362-372
pubmed: 31132311
Am J Physiol Heart Circ Physiol. 2019 Jul 1;317(1):H124-H140
pubmed: 31074651
Circulation. 2000 Feb 1;101(4):385-91
pubmed: 10653829
Nature. 2020 Dec;588(7838):466-472
pubmed: 32971526
Circ Heart Fail. 2020 Nov;13(11):e007405
pubmed: 33176455
J Immunol. 1992 Apr 15;148(8):2423-8
pubmed: 1348518
J Cardiol. 2017 Feb;69(2):409-416
pubmed: 27890513
Circulation. 2020 Aug 4;142(5):466-482
pubmed: 32403949
Immunity. 2004 Oct;21(4):467-76
pubmed: 15485625
Pediatr Cardiol. 1995 Mar-Apr;16(2):61-8
pubmed: 7784236
Curr Cardiol Rep. 2023 Jul;25(7):631-640
pubmed: 37249739
N Engl J Med. 1997 Feb 20;336(8):525-33
pubmed: 9036306
Medicine (Baltimore). 2021 Jul 2;100(26):e26475
pubmed: 34190171
Ther Adv Cardiovasc Dis. 2016 Feb;10(1):30-6
pubmed: 26627265
Eur Heart J. 2009 Aug;30(16):1995-2002
pubmed: 19556262
J Am Coll Cardiol. 2015 Nov 3;66(18):2038-2047
pubmed: 26516007
Nat Med. 2018 Aug;24(8):1234-1245
pubmed: 29892064
Arch Dis Child. 2004 Jun;89(6):580-4
pubmed: 15155409
Front Immunol. 2020 Apr 09;11:639
pubmed: 32328072
Circ Res. 2000 Jun 23;86(12):1259-65
pubmed: 10864917
Cell Physiol Biochem. 2018;46(1):23-35
pubmed: 29566367
Cardiovasc Res. 2021 Jan 21;117(2):484-494
pubmed: 32311026
Circulation. 2005 Aug 23;112(8):1128-35
pubmed: 16103243
Mol Aspects Med. 2019 Feb;65:70-99
pubmed: 30056242
J Immunol. 2016 Feb 1;196(3):1060-9
pubmed: 26740107
Circulation. 2003 Feb 18;107(6):857-63
pubmed: 12591756
Cell Mol Immunol. 2013 Mar;10(2):122-32
pubmed: 23292280
J Interferon Cytokine Res. 2009 Jun;29(6):313-26
pubmed: 19441883
PLoS One. 2012;7(12):e52911
pubmed: 23300817
Trends Cardiovasc Med. 2009 Nov;19(8):247-52
pubmed: 20447565
Annu Rev Immunol. 1997;15:749-95
pubmed: 9143706
Circulation. 2001 Jan 2;103(1):18-21
pubmed: 11136679
Int J Cardiol. 2008 Jun 6;126(3):427-9
pubmed: 17467829
N Engl J Med. 2014 Sep 11;371(11):993-1004
pubmed: 25176015
PLoS One. 2008 Jul 16;3(7):e2705
pubmed: 18628982
Nat Commun. 2022 Aug 6;13(1):4580
pubmed: 35933399
J Card Fail. 2011 Apr;17(4):272-81
pubmed: 21440864
J Clin Immunol. 2013 Jul;33(5):1002-8
pubmed: 23558825
Curr Cardiol Rev. 2011 Nov;7(4):214-20
pubmed: 22758622
Circ Heart Fail. 2015 Jul;8(4):776-87
pubmed: 26022677
Circulation. 2001 May 8;103(18):2254-9
pubmed: 11342473
Int J Mol Sci. 2019 May 19;20(10):
pubmed: 31109146
BMC Cardiovasc Disord. 2015 Mar 26;15:26
pubmed: 25888309
Am J Transplant. 2004;4 Suppl 9:38-53
pubmed: 15113354
Oncotarget. 2016 Jul 5;7(27):42826-42836
pubmed: 27095576
Circ Res. 2004 Jun 25;94(12):1543-53
pubmed: 15217919
Immunity. 2021 Sep 14;54(9):2072-2088.e7
pubmed: 34320366
Int J Cardiol. 2004 Dec;97(3):529-34
pubmed: 15561344
Rev Cardiovasc Med. 2022 Mar 17;23(3):108
pubmed: 35345275
Hippokratia. 2011 Oct;15(4):335-42
pubmed: 24391416
Int J Cardiol. 2018 Nov 1;270:278-286
pubmed: 30082120
J Exp Med. 2014 Jun 30;211(7):1449-64
pubmed: 24935258
Eur J Heart Fail. 2021 Feb;23(2):302-309
pubmed: 33347677
N Engl J Med. 1995 Aug 3;333(5):269-75
pubmed: 7596370
Clin Immunol. 2017 Feb;175:26-33
pubmed: 27894980
J Leukoc Biol. 2015 Apr;97(4):797-805
pubmed: 25722319
Eur Heart J. 2017 May 07;38(18):1413-1425
pubmed: 27099262
Circ Cardiovasc Imaging. 2017 Dec;10(12):e006709
pubmed: 29237609
Front Immunol. 2018 Apr 27;9:911
pubmed: 29755478
Cardiovasc Res. 2016 May 1;110(1):51-61
pubmed: 26825554
J Card Fail. 2011 Oct;17(10):844-9
pubmed: 21962423
Nat Rev Dis Primers. 2019 May 9;5(1):32
pubmed: 31073128
Clin Res Cardiol. 2011 Jul;100(7):603-10
pubmed: 21298435
J Biol Chem. 2017 Apr 7;292(14):6004-6013
pubmed: 27974462
Immunity. 2018 Feb 20;48(2):202-213
pubmed: 29466753
Int J Biol Sci. 2018 Sep 7;14(12):1645-1657
pubmed: 30416379
Front Immunol. 2018 Apr 23;9:835
pubmed: 29740441
Int J Cardiol. 2011 Apr 14;148(2):204-8
pubmed: 19945184
Immunity. 2014 Jan 16;40(1):91-104
pubmed: 24439267
Front Cardiovasc Med. 2021 Aug 23;8:696321
pubmed: 34497835
Circ Res. 2016 Feb 5;118(3):400-9
pubmed: 26635390
Eur J Immunol. 2012 Sep;42(9):2311-21
pubmed: 22730043
J Transl Med. 2019 Jul 11;17(1):221
pubmed: 31296244
Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1013-22
pubmed: 15087287
Clin Res Cardiol. 2010 Oct;99(10):633-8
pubmed: 20419455
Transfus Apher Sci. 2017 Oct;56(5):666-670
pubmed: 28970002
Immunology. 2017 Jul;151(3):291-303
pubmed: 28207945
J Biomed Sci. 2017 Feb 7;24(1):13
pubmed: 28173864
J Mol Med (Berl). 2007 Dec;85(12):1429-35
pubmed: 17924085
Eur J Heart Fail. 2013 Sep;15(9):974-85
pubmed: 23603088
Ann Pediatr Cardiol. 2019 Jan-Apr;12(1):18-24
pubmed: 30745765
Transl Res. 2018 Jan;191:15-28
pubmed: 29106912
Am J Physiol Regul Integr Comp Physiol. 2013 Feb 15;304(4):R267-77
pubmed: 23255589
Eur Heart J. 2013 Mar;34(9):666-75
pubmed: 23100283
Nat Rev Cardiol. 2021 Mar;18(3):169-193
pubmed: 33046850
J Immunol. 2013 Oct 15;191(8):4038-47
pubmed: 24048893
Eur J Heart Fail. 2017 Apr;19(4):490-498
pubmed: 28217949
Fibrogenesis Tissue Repair. 2015 Apr 23;8:7
pubmed: 25949522
J Immunol. 2017 Jul 1;199(1):17-24
pubmed: 28630109
J Am Coll Cardiol. 2012 Jul 24;60(4):283-9
pubmed: 22813604
Front Immunol. 2018 Sep 05;9:1913
pubmed: 30258433