Analysis of Metabolites in Gout: A Systematic Review and Meta-Analysis.
gout
meta-inflammation
metabolites
metabolomics
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
14 Jul 2023
14 Jul 2023
Historique:
received:
21
06
2023
revised:
04
07
2023
accepted:
11
07
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
(1) Background: Many studies have attempted to explore potential biomarkers for the early detection of gout, but consistent and high levels of evidence are lacking. In this study, metabolomics was used to summarize the changes of metabolites in the literature and explore the potential value of metabolites in predicting the occurrence and development of gout. (2) Methods: We searched the databases including the EMBASE, the Cochrane Library, PubMed, Web of Science, VIP Date, Wanfang Data, and CNKI, and the screening was fulfilled on 30 July 2022. The records were screened according to the inclusion criteria and the risk of bias was assessed. Qualitative analysis was performed for all metabolites, and meta-analysis was performed for metabolite concentrations using random effects to calculate the Std mean difference and 95% confidence interval. (3) Results: A total of 2738 records were identified, 33 studies with 3422 participants were included, and 701 metabolites were identified. The qualitative analysis results showed that compared with the healthy control group, the concentration of 56 metabolites increased, and 22 metabolites decreased. The results of the meta-analysis indicated that 17 metabolites were statistically significant. (4) Conclusions: Metabolites are associated with gout. Some specific metabolites such as uric acid, hypoxanthine, xanthine, KYNA, guanosine, adenosine, creatinine, LB4, and DL-2-Aminoadipic acid have been highlighted in the development of gout.
Identifiants
pubmed: 37513561
pii: nu15143143
doi: 10.3390/nu15143143
pmc: PMC10383779
pii:
doi:
Substances chimiques
Uric Acid
268B43MJ25
Xanthine
1AVZ07U9S7
Hypoxanthine
2TN51YD919
Creatinine
AYI8EX34EU
Types de publication
Meta-Analysis
Systematic Review
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 82074299
Références
Nat Biotechnol. 2018 Apr 5;36(4):316-320
pubmed: 29621222
J Rheumatol. 2000 Jun;27(6):1501-5
pubmed: 10852278
Arthritis Rheumatol. 2020 Nov;72(11):1786-1788
pubmed: 33150696
J Rheumatol. 1999 Sep;26(9):2068-9
pubmed: 10493700
Cells. 2021 Oct 21;10(11):
pubmed: 34831057
Lancet. 1982 Nov 20;2(8308):1122-4
pubmed: 6128450
Biomed Res Int. 2017;2017:4391920
pubmed: 28116308
Curr Pharm Des. 2018;24(6):684-689
pubmed: 29336252
Mol Omics. 2021 Apr 1;17(2):210-229
pubmed: 33598670
Rheumatology (Oxford). 2020 Oct 1;59(10):2960-2969
pubmed: 32134107
Nat Rev Rheumatol. 2020 Jul;16(7):380-390
pubmed: 32541923
Curr Rheumatol Rep. 2017 Aug 26;19(10):60
pubmed: 28844079
J Clin Lab Anal. 2019 Jun;33(5):e22868
pubmed: 30803031
PeerJ. 2021 Dec 01;9:e12585
pubmed: 34917427
Nat Rev Dis Primers. 2019 Sep 26;5(1):69
pubmed: 31558729
Curr Opin Rheumatol. 2011 Mar;23(2):192-202
pubmed: 21285714
Nature. 2006 Mar 9;440(7081):237-41
pubmed: 16407889
Semin Nephrol. 2020 Nov;40(6):550-563
pubmed: 33678310
Mutat Res. 2017 Oct;803-805:9-16
pubmed: 28704682
Clin Chim Acta. 2011 Nov 20;412(23-24):2132-40
pubmed: 21867696
Eur J Epidemiol. 2010 Sep;25(9):603-5
pubmed: 20652370
Pharmacotherapy. 2016 Aug;36(8):906-22
pubmed: 27318031
BMJ. 2021 Mar 29;372:n71
pubmed: 33782057
J Pharm Biomed Anal. 2015 Sep 10;113:108-20
pubmed: 25577715
Nat Rev Rheumatol. 2014 May;10(5):271-83
pubmed: 24614592
Ann Rheum Dis. 2014 Aug;73(8):1470-6
pubmed: 24590182
Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1366-76
pubmed: 27029427
Inflammopharmacology. 2011 Feb;19(1):1-19
pubmed: 21072600
Rheumatology (Oxford). 2014 Nov;53(11):1958-65
pubmed: 24899662
Clin Chem. 2005 Sep;51(9):1742-4
pubmed: 16120958
Anal Chem. 2017 Nov 7;89(21):11737-11743
pubmed: 28972752
Prostaglandins Other Lipid Mediat. 2018 Nov;139:63-70
pubmed: 30393163
Sci Rep. 2021 Mar 11;11(1):5684
pubmed: 33707563
Pharmazie. 2021 Nov 1;76(11):551-558
pubmed: 34782040
J Clin Invest. 2010 Jun;120(6):1791-9
pubmed: 20516647
Biomolecules. 2021 Feb 14;11(2):
pubmed: 33672821
Biomed Res Int. 2018 Oct 16;2018:3461572
pubmed: 30410926
Am J Nephrol. 1995;15(1):31-7
pubmed: 7872362
Semin Arthritis Rheum. 2020 Jun;50(3S):S24-S30
pubmed: 32620199
Mol Biosyst. 2012 Nov;8(11):2956-63
pubmed: 22932763
Int J Mol Med. 2019 Jul;44(1):172-184
pubmed: 31059009
J Rheumatol. 2009 Jun;36(6):1287-9
pubmed: 19369457
Pediatr Nephrol. 2014 Jun;29(6):999-1008
pubmed: 23824181
J Clin Pharmacol. 1991 Jul;31(7):588-98
pubmed: 1894754
Ann Rheum Dis. 2020 Jan;79(1):31-38
pubmed: 31167758
Curr Opin Rheumatol. 2014 Mar;26(2):186-91
pubmed: 24419750
Arthritis Rheumatol. 2021 Sep;73(9):1738-1748
pubmed: 33760368
Semin Arthritis Rheum. 2022 Aug;55:152022
pubmed: 35584580
Front Microbiol. 2017 Feb 21;8:268
pubmed: 28270806
Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2097-103
pubmed: 22772752
Semin Arthritis Rheum. 2015 Aug;45(1):75-80
pubmed: 25912932
Int J Biochem Cell Biol. 1998 Feb;30(2):173-8
pubmed: 9608670
J Am Soc Nephrol. 2002 Dec;13(12):2888-97
pubmed: 12444207
Curr Pharm Des. 2018;24(6):675-683
pubmed: 29359660
Rheumatol Int. 2021 Jul;41(7):1209-1219
pubmed: 33987709
BMJ. 1997 Sep 13;315(7109):629-34
pubmed: 9310563
J Proteome Res. 2013 Aug 2;12(8):3769-79
pubmed: 23819623
Rheumatology (Oxford). 2022 May 30;61(6):2644-2651
pubmed: 34599805
Arthritis Res Ther. 2018 Jun 5;20(1):111
pubmed: 29871692
Nature. 2017 Feb 8;542(7640):177-185
pubmed: 28179656
Front Immunol. 2021 Dec 01;12:785425
pubmed: 34925366
PLoS One. 2010 Jul 28;5(7):e11825
pubmed: 20689575
Curr Probl Cardiol. 2023 Jan;48(1):101437
pubmed: 36183979
J Rheumatol. 2011 Jul;38(7):1385-9
pubmed: 21572152
BMC Nephrol. 2019 Mar 18;20(1):95
pubmed: 30885171
J Sep Sci. 2021 Mar;44(5):954-962
pubmed: 33348445
Rheumatology (Oxford). 2020 Jul 1;59(7):1529-1538
pubmed: 31624843
Ann Rheum Dis. 2015 Apr;74(4):661-7
pubmed: 24431399
J Sep Sci. 2019 Aug;42(15):2523-2533
pubmed: 31144454
Ther Drug Monit. 2000 Apr;22(2):177-83
pubmed: 10774630
Front Immunol. 2018 Jan 10;8:1957
pubmed: 29379504
Am J Physiol Renal Physiol. 2020 Jun 1;318(6):F1327-F1340
pubmed: 32223310
Stroke. 2016 Apr;47(4):943-50
pubmed: 26917565
Lancet. 2016 Oct 22;388(10055):2039-2052
pubmed: 27112094
Curr Rheumatol Rep. 2022 May;24(5):132-138
pubmed: 35420373
Am J Physiol Renal Physiol. 2015 May 1;308(9):F993-F1003
pubmed: 25651569
Mol Immunol. 2015 Aug;66(2):310-8
pubmed: 25909495
Rheumatology (Oxford). 2019 Feb 1;58(2):345-351
pubmed: 30247644
Semin Arthritis Rheum. 2018 Apr;47(5):689-702
pubmed: 29198878
BMJ. 2022 Aug 30;378:o1754
pubmed: 36041743
BMJ. 2011 Jul 22;343:d4002
pubmed: 21784880