Serotonin transporter-deficient mice display enhanced adipose tissue inflammation after chronic high-fat diet feeding.
adipose tissue
inflammation
metabolic syndrome
obesity
serotonin
serotonin transporter
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
10
03
2023
accepted:
13
06
2023
medline:
23
10
2023
pubmed:
31
7
2023
entrez:
31
7
2023
Statut:
epublish
Résumé
Serotonin is involved in leukocyte recruitment during inflammation. Deficiency of the serotonin transporter (SERT) is associated with metabolic changes in humans and mice. A possible link and interaction between the inflammatory effects of serotonin and metabolic derangements in SERT-deficient mice has not been investigated so far. SERT-deficient ( After 19 weeks of high-fat diet, Our observations suggest that SERT deficiency in mice is associated with inflammatory processes that manifest as increased adipose tissue inflammation upon chronic high-fat diet feeding due to enhanced leukocyte recruitment.
Identifiants
pubmed: 37520561
doi: 10.3389/fimmu.2023.1184010
pmc: PMC10372416
doi:
Substances chimiques
Serotonin Plasma Membrane Transport Proteins
0
Serotonin
333DO1RDJY
RNA, Messenger
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1184010Informations de copyright
Copyright © 2023 Hoch, Burkhard, Zhang, Rieder, Marchini, Geest, Krauel, Zahn, Schommer, Hamad, Bauer, Gauchel, Stallmann, Normann, Wolf, Scharf, Duerschmied and Schanze.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Sci Rep. 2017 Apr 25;7(1):1137
pubmed: 28442777
J Thromb Haemost. 2022 Jan;20(1):222-229
pubmed: 34592035
J Clin Invest. 2018 Apr 2;128(4):1538-1550
pubmed: 29528335
J Clin Med. 2021 Jul 14;10(14):
pubmed: 34300270
Nature. 2017 Feb 8;542(7640):177-185
pubmed: 28179656
PLoS One. 2012;7(3):e32511
pubmed: 22412882
Nat Commun. 2015 Apr 13;6:6794
pubmed: 25864946
Blood. 2013 Feb 7;121(6):1008-15
pubmed: 23243271
Arch Gen Psychiatry. 2010 Mar;67(3):220-9
pubmed: 20194822
Immunity. 2022 Jan 11;55(1):31-55
pubmed: 35021057
Endocr J. 1999 Mar;46(Suppl):S25-34
pubmed: 12054114
J Exp Med. 2021 May 3;218(5):
pubmed: 33822846
Microbiol Spectr. 2016 Oct;4(5):
pubmed: 27780020
Platelets. 2016 Jul;27(5):467-71
pubmed: 26950533
Front Cardiovasc Med. 2017 Jul 20;4:48
pubmed: 28775986
Sci Rep. 2019 Feb 14;9(1):2138
pubmed: 30765765
Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1304-10
pubmed: 18420999
Nat Med. 2015 Feb;21(2):166-72
pubmed: 25485911
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2686-91
pubmed: 24492375
Front Biosci (Landmark Ed). 2019 Jan 1;24(3):514-526
pubmed: 30468670
Nat Med. 2009 Aug;15(8):914-20
pubmed: 19633658
Front Psychiatry. 2020 Feb 14;11:35
pubmed: 32116850
Lab Invest. 2011 Jul;91(7):1107-17
pubmed: 21519329
Diabetologia. 2012 Oct;55(10):2565-2582
pubmed: 22869320
Diabetes. 2013 Jan;62(1):56-64
pubmed: 22961088
Circulation. 2019 Feb 12;139(7):918-931
pubmed: 30586717
Cells. 2021 Jul 22;10(8):
pubmed: 34440624
Int J Obes (Lond). 2010 Apr;34(4):701-11
pubmed: 20084070
Circulation. 2007 Feb 27;115(8):946-8
pubmed: 17325252
Nutrients. 2020 May 03;12(5):
pubmed: 32375231
Mol Metab. 2022 Dec;66:101642
pubmed: 36402403
Clin Nutr. 2021 Apr;40(4):2025-2034
pubmed: 33008652
Nat Metab. 2021 Jul;3(7):883-886
pubmed: 34117483
Thromb Haemost. 2001 May;85(5):924-8
pubmed: 11372689
Diabetes Obes Metab. 2011 Jun;13(6):551-8
pubmed: 21320265
Cell Mol Gastroenterol Hepatol. 2019;7(2):447-456
pubmed: 30739869
Pharmacol Res. 2019 Feb;140:100-114
pubmed: 29953943
Science. 2003 Jan 3;299(5603):76
pubmed: 12511643
Endocrinol Metab (Seoul). 2020 Jun;35(2):470-479
pubmed: 32615731
Clin Chim Acta. 2010 Feb;411(3-4):167-71
pubmed: 19891962
Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G685-95
pubmed: 19095763
BMC Genet. 2016 Nov 17;17(1):145
pubmed: 27855657
Gastroenterology. 2007 Jan;132(1):397-414
pubmed: 17241888
Cell Metab. 2022 Jan 4;34(1):11-20
pubmed: 34986330
Lab Invest. 2012 Nov;92(11):1597-606
pubmed: 22964849
Biochem J. 2014 Jul 15;461(2):177-88
pubmed: 24966052
J Pharmacol Exp Ther. 2019 Oct;371(1):113-120
pubmed: 31308195
JAMA Pediatr. 2017 Dec 1;171(12):1200-1207
pubmed: 29049533
J Clin Invest. 2021 Dec 1;131(23):
pubmed: 34618686
Circulation. 2007 Feb 27;115(8):1029-38
pubmed: 17296858
Obesity (Silver Spring). 2007 Feb;15(2):271-6
pubmed: 17299098
Obesity (Silver Spring). 2008 Feb;16(2):348-55
pubmed: 18239643
J Clin Invest. 2017 Jan 3;127(1):74-82
pubmed: 28045400
Front Neurosci. 2020 Feb 18;14:24
pubmed: 32132889
Semin Thromb Hemost. 2012 Nov;38(8):865-83
pubmed: 23111864