The bioinformatics analysis of CD59 in Helicobacter pylori infected gastric cancer.
CD59
H. pylori
bioinformatics
gastric cancer
Journal
Cancer biomarkers : section A of Disease markers
ISSN: 1875-8592
Titre abrégé: Cancer Biomark
Pays: Netherlands
ID NLM: 101256509
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
12
9
2023
pubmed:
31
7
2023
entrez:
31
7
2023
Statut:
ppublish
Résumé
Cell surface molecules play important roles in cell signal transduction pathways during microbial infection. In this study, the expression and the functions of CD59 was investigated in H. pylori infected gastric cancer (GC). The differential expression of CD59 and the influence of H. pylori on the expression of CD59 were analyzed via bioinformatics through Gene Set Enrichment in GC. In addition, the expression of CD59 in GES-1, AGS cells and GC tissues infected with H. pylori was confirmed by Western blot. Bioinformatics results and H. pylori infection experiments showed CD59 decreased obviously in H. pylori infected GC cells and tissues. The expression of CD59 was linked to the survival rate of GC patients, and influenced various immune cells in the immune microenvironment of GC. CD59 interacts with other genes to form a network in H. pylori infected GC. Certainly, CD59 decreased significantly in H. pylori infected GC tissues, GES-1 and AGS cells in vitro. H. pylori infection could influence the expression of CD59 in GC indicating that CD59 may be a promising treatment target.
Sections du résumé
BACKGROUND
BACKGROUND
Cell surface molecules play important roles in cell signal transduction pathways during microbial infection.
OBJECTIVE
OBJECTIVE
In this study, the expression and the functions of CD59 was investigated in H. pylori infected gastric cancer (GC).
METHODS AND RESULTS
RESULTS
The differential expression of CD59 and the influence of H. pylori on the expression of CD59 were analyzed via bioinformatics through Gene Set Enrichment in GC. In addition, the expression of CD59 in GES-1, AGS cells and GC tissues infected with H. pylori was confirmed by Western blot. Bioinformatics results and H. pylori infection experiments showed CD59 decreased obviously in H. pylori infected GC cells and tissues. The expression of CD59 was linked to the survival rate of GC patients, and influenced various immune cells in the immune microenvironment of GC. CD59 interacts with other genes to form a network in H. pylori infected GC. Certainly, CD59 decreased significantly in H. pylori infected GC tissues, GES-1 and AGS cells in vitro.
CONCLUSION
CONCLUSIONS
H. pylori infection could influence the expression of CD59 in GC indicating that CD59 may be a promising treatment target.
Identifiants
pubmed: 37522198
pii: CBM230034
doi: 10.3233/CBM-230034
doi:
Substances chimiques
CD59 protein, human
101754-01-2
CD59 Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM