Insulin Glargine is More Suitable Than Exenatide in Preventing Muscle Loss in Non-Obese Type 2 Diabetic Patients with NAFLD.
Journal
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
ISSN: 1439-3646
Titre abrégé: Exp Clin Endocrinol Diabetes
Pays: Germany
ID NLM: 9505926
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
medline:
16
11
2023
pubmed:
1
8
2023
entrez:
31
7
2023
Statut:
ppublish
Résumé
This study investigated the effects of insulin glargine and exenatide on the muscle mass of patients with newly diagnosed type 2 diabetes (T2DM) and nonalcoholic fatty liver disease (NAFLD). We performed a post-hoc analysis of our previously study, a 24-week randomized controlled multicenter clinical trial (ClinicalTrials.gov, NCT02303730). Seventy-six patients were randomly assigned 1:1 to receive insulin glargine or exenatide treatment. The changes in psoas muscle area (PMA) (mm There were no significant differences in age, BMI, gender, and PMA in insulin glargine and exenatide groups at baseline. After treatment, PMA tended to increase by 13.13 (-215.52, 280.80) mm Compared to exenatide, insulin glargine can relativity increase PMA in patients with T2DM having BMI<28 kg/m
Identifiants
pubmed: 37524110
doi: 10.1055/a-2145-1004
pmc: PMC10645484
doi:
Substances chimiques
Insulin Glargine
2ZM8CX04RZ
Exenatide
9P1872D4OL
Hypoglycemic Agents
0
Venoms
0
Banques de données
ClinicalTrials.gov
['NCT02303730']
Types de publication
Randomized Controlled Trial
Multicenter Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
583-588Subventions
Organisme : Medical Guidance Project of Shanghai Science and Technology Commission
ID : 19401931100 to Wang XY
Organisme : Science and Technology Commission of Shanghai Municipality
ID : 21ZR1413200 to HM Yan
Organisme : Scientific Research and Development Foundation of Zhongshan Hospital, Fudan University
ID : 2019ZSFZ10 to HD LIN
Informations de copyright
The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest.
Références
Endocrinol Nutr. 2016 Jun-Jul;63(6):291-303
pubmed: 26971016
Age Ageing. 2014 Nov;43(6):748-59
pubmed: 25241753
Diabetes. 1998 Dec;47(12):1824-35
pubmed: 9836512
J Cachexia Sarcopenia Muscle. 2019 Aug;10(4):903-918
pubmed: 31020810
Clin Interv Aging. 2020 Sep 16;15:1675-1690
pubmed: 32982201
Diabetes Metab Res Rev. 2020 Jul;36(5):e3292
pubmed: 31955491
Nutrients. 2021 Jan 09;13(1):
pubmed: 33435310
Calcif Tissue Int. 2020 Nov;107(5):453-463
pubmed: 32772138
Calcif Tissue Int. 2017 Jul;101(1):1-8
pubmed: 28246927
J Cachexia Sarcopenia Muscle. 2021 Dec;12(6):1368-1379
pubmed: 34676695
J Dig Dis. 2008 May;9(2):108-12
pubmed: 18419645
Trends Endocrinol Metab. 2021 Feb;32(2):106-117
pubmed: 33358931
Curr Diabetes Rev. 2021;17(3):293-303
pubmed: 32628589
BMJ. 2020 Apr 28;369:m997
pubmed: 32345662
Lancet. 2012 Dec 15;380(9859):2144-62
pubmed: 23245606
J Clin Invest. 2016 Sep 1;126(9):3433-46
pubmed: 27525440
Age Ageing. 2019 Jan 1;48(1):16-31
pubmed: 30312372
J Am Med Dir Assoc. 2017 Sep 1;18(9):809.e9-809.e13
pubmed: 28739493
Diabetes Res Clin Pract. 2018 Apr;138:271-281
pubmed: 29496507
Diabetes Obes Metab. 2016 Sep;18(9):882-91
pubmed: 27106272
Aging Clin Exp Res. 2016 Dec;28(6):1251-1257
pubmed: 26749118
Sci Rep. 2016 Dec 13;6:38937
pubmed: 27958337
Diabetologia. 2020 Mar;63(3):473-485
pubmed: 31897524
Obes Facts. 2018;11(6):454-464
pubmed: 30537756
J Diabetes Res. 2020 Jul 9;2020:9368583
pubmed: 32695832
J Diabetes Metab Disord. 2017 May 16;16:21
pubmed: 28523252
Diabetes Res Clin Pract. 2014 Mar;103(3):538-40
pubmed: 24731476
Nutrients. 2020 May 01;12(5):
pubmed: 32370051
Ageing Res Rev. 2021 May;67:101305
pubmed: 33610815