The CAR-HEMATOTOX score as a prognostic model of toxicity and response in patients receiving BCMA-directed CAR-T for relapsed/refractory multiple myeloma.


Journal

Journal of hematology & oncology
ISSN: 1756-8722
Titre abrégé: J Hematol Oncol
Pays: England
ID NLM: 101468937

Informations de publication

Date de publication:
31 07 2023
Historique:
received: 05 03 2023
accepted: 09 06 2023
medline: 2 8 2023
pubmed: 1 8 2023
entrez: 31 7 2023
Statut: epublish

Résumé

BCMA-directed CAR T-cell therapy (CAR-T) has altered the treatment landscape of relapsed/refractory (r/r) multiple myeloma, but is hampered by unique side effects that can lengthen hospital stays and increase morbidity. Hematological toxicity (e.g. profound and prolonged cytopenias) represents the most common grade ≥ 3 toxicity and can predispose for severe infectious complications. Here, we examined the utility of the CAR-HEMATOTOX (HT) score to predict toxicity and survival outcomes in patients receiving standard-of-care idecabtagene vicleucel and ciltacabtagene autoleucel. Data were retrospectively collected from 113 r/r multiple myeloma patients treated between April 2021 and July 2022 across six international CAR-T centers. The HT score-composed of factors related to hematopoietic reserve and baseline inflammatory state-was determined prior to lymphodepleting chemotherapy. At lymphodepletion, 63 patients were HT These data highlight the prognostic utility of the CAR-HEMATOTOX score for both toxicity and treatment response in multiple myeloma patients receiving BCMA-directed CAR-T. The score may guide toxicity management (e.g. anti-infective prophylaxis, early G-CSF, stem cell boost) and help to identify suitable CAR-T candidates.

Sections du résumé

BACKGROUND
BCMA-directed CAR T-cell therapy (CAR-T) has altered the treatment landscape of relapsed/refractory (r/r) multiple myeloma, but is hampered by unique side effects that can lengthen hospital stays and increase morbidity. Hematological toxicity (e.g. profound and prolonged cytopenias) represents the most common grade ≥ 3 toxicity and can predispose for severe infectious complications. Here, we examined the utility of the CAR-HEMATOTOX (HT) score to predict toxicity and survival outcomes in patients receiving standard-of-care idecabtagene vicleucel and ciltacabtagene autoleucel.
METHODS
Data were retrospectively collected from 113 r/r multiple myeloma patients treated between April 2021 and July 2022 across six international CAR-T centers. The HT score-composed of factors related to hematopoietic reserve and baseline inflammatory state-was determined prior to lymphodepleting chemotherapy.
RESULTS
At lymphodepletion, 63 patients were HT
CONCLUSIONS
These data highlight the prognostic utility of the CAR-HEMATOTOX score for both toxicity and treatment response in multiple myeloma patients receiving BCMA-directed CAR-T. The score may guide toxicity management (e.g. anti-infective prophylaxis, early G-CSF, stem cell boost) and help to identify suitable CAR-T candidates.

Identifiants

pubmed: 37525244
doi: 10.1186/s13045-023-01465-x
pii: 10.1186/s13045-023-01465-x
pmc: PMC10391746
doi:

Substances chimiques

Receptors, Chimeric Antigen 0
B-Cell Maturation Antigen 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

88

Informations de copyright

© 2023. The Author(s).

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Auteurs

Kai Rejeski (K)

Department of Medicine III - Hematology/Oncology, LMU University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany. kai.rejeski@med.uni-muenchen.de.
Laboratory for Translational Cancer Immunology, LMU Gene Center, Munich, Germany. kai.rejeski@med.uni-muenchen.de.
German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany. kai.rejeski@med.uni-muenchen.de.
Bavarian Cancer Research Center (BZKF), Munich partner site, Munich, Germany. kai.rejeski@med.uni-muenchen.de.

Doris K Hansen (DK)

Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, USA.

Radhika Bansal (R)

Division of Hematology, Mayo Clinic, Rochester, MN, USA.

Pierre Sesques (P)

Hospices Civils de Lyon, Université Claude Bernard Lyon 1, INSERM 1052, Pierre-Bénite, France.

Sikander Ailawadhi (S)

Division of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USA.

Jennifer M Logue (JM)

Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, USA.

Eva Bräunlein (E)

IIIrd Medical Department, Klinikum rechts der Isar and Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.

David M Cordas Dos Santos (DM)

Department of Medicine III - Hematology/Oncology, LMU University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany.
German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany.

Ciara L Freeman (CL)

Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, USA.

Melissa Alsina (M)

Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, USA.

Sebastian Theurich (S)

Department of Medicine III - Hematology/Oncology, LMU University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany.
German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany.

Yucai Wang (Y)

Division of Hematology, Mayo Clinic, Rochester, MN, USA.

Angela M Krackhardt (AM)

German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany.
Bavarian Cancer Research Center (BZKF), Munich partner site, Munich, Germany.
IIIrd Medical Department, Klinikum rechts der Isar and Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technical University of Munich, Munich, Germany.
Department of Medicine I, Malteser Hospital St. Franziskus Hospital, Flensburg, Germany.

Frederick L Locke (FL)

Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, USA.

Emmanuel Bachy (E)

Hospices Civils de Lyon, Université Claude Bernard Lyon 1, INSERM 1052, Pierre-Bénite, France.

Michael D Jain (MD)

Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, USA.

Yi Lin (Y)

Division of Hematology, Mayo Clinic, Rochester, MN, USA.

Marion Subklewe (M)

Department of Medicine III - Hematology/Oncology, LMU University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany.
Laboratory for Translational Cancer Immunology, LMU Gene Center, Munich, Germany.
German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany.
Bavarian Cancer Research Center (BZKF), Munich partner site, Munich, Germany.

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