Turning Down the Temperature on Leukemia Stem Cells.
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
01 08 2023
01 08 2023
Historique:
received:
08
06
2023
accepted:
09
06
2023
medline:
2
8
2023
pubmed:
1
8
2023
entrez:
1
8
2023
Statut:
ppublish
Résumé
Oxidative phosphorylation (OXPHOS) is a well-documented dependency of leukemia stem cells (LSC). In this issue of Cancer Research, Griessinger and colleagues have identified cold sensitivity as a new vulnerability of OXPHOS-dependent LSCs. Mechanistically, cold sensitive leukemic cell death is caused by membrane permeabilization due to OXPHOS-dependent differences in membrane lipid species abundance. This work sheds new light onto the contribution of OXPHOS to lipid homeostasis in LSCs and has important implications for the handling and processing of primary acute myeloid leukemia specimens. See related article by Griessinger et al., p. 2461.
Identifiants
pubmed: 37525977
pii: 728075
doi: 10.1158/0008-5472.CAN-23-1387
doi:
Substances chimiques
Fatty Acids
0
Types de publication
Editorial
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
2441-2442Commentaires et corrections
Type : CommentOn
Informations de copyright
©2023 American Association for Cancer Research.