Myocardial Fibrosis and Cardiomyopathy Risk: A Genetic Link in the MESA.
cardiomyopathy
fibroblasts
fibrosis
genetics
heart failure
magnetic resonance imaging
risk
Journal
Circulation. Heart failure
ISSN: 1941-3297
Titre abrégé: Circ Heart Fail
Pays: United States
ID NLM: 101479941
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
pmc-release:
01
09
2024
medline:
21
9
2023
pubmed:
1
8
2023
entrez:
1
8
2023
Statut:
ppublish
Résumé
Common genetic variants are associated with risk for hypertrophic cardiomyopathy and dilated cardiomyopathy and with left ventricular (LV) traits. Whether these variants are associated with myocardial fibrosis, an important pathophysiological mediator of cardiomyopathy, is unknown. Multi-Ethnic Study of Atherosclerosis participants with T1-mapping cardiac magnetic resonance imaging in-whom extracellular volume was assessed, and genotyping information was available were included (N=1255). Log extracellular volume (%) was regressed on 50 candidate single nucleotide polymorphisms (previously identified to be associated with hypertrophic cardiomyopathy, dilated cardiomyopathy, and LV traits) adjusting for age, sex, diabetes, blood pressure, and principal components of ancestry. Ancestry-specific results were pooled by fixed-effect meta-analyses. Gene knockdown experiments were performed in human cardiac fibroblasts. The Common genetic variation in
Sections du résumé
BACKGROUND
Common genetic variants are associated with risk for hypertrophic cardiomyopathy and dilated cardiomyopathy and with left ventricular (LV) traits. Whether these variants are associated with myocardial fibrosis, an important pathophysiological mediator of cardiomyopathy, is unknown.
METHODS
Multi-Ethnic Study of Atherosclerosis participants with T1-mapping cardiac magnetic resonance imaging in-whom extracellular volume was assessed, and genotyping information was available were included (N=1255). Log extracellular volume (%) was regressed on 50 candidate single nucleotide polymorphisms (previously identified to be associated with hypertrophic cardiomyopathy, dilated cardiomyopathy, and LV traits) adjusting for age, sex, diabetes, blood pressure, and principal components of ancestry. Ancestry-specific results were pooled by fixed-effect meta-analyses. Gene knockdown experiments were performed in human cardiac fibroblasts.
RESULTS
The
CONCLUSIONS
Common genetic variation in
Identifiants
pubmed: 37526028
doi: 10.1161/CIRCHEARTFAILURE.122.010262
pmc: PMC10602591
mid: NIHMS1911779
doi:
Substances chimiques
Contrast Media
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e010262Subventions
Organisme : NHLBI NIH HHS
ID : 75N92020D00002
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92020D00005
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95160
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95163
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001079
Pays : United States
Organisme : NHLBI NIH HHS
ID : N02 HL64278
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95164
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95168
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95165
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95159
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92020D00007
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95167
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001881
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92020D00001
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95169
Pays : United States
Organisme : NHLBI NIH HHS
ID : N02HL64278
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95162
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92020D00003
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95161
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001420
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92020D00004
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95166
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL159987
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92020D00006
Pays : United States
Références
Nat Rev Cardiol. 2015 Jan;12(1):18-29
pubmed: 25348690
Eur Radiol. 2021 Jul;31(7):4557-4567
pubmed: 33449190
Radiology. 2012 Dec;265(3):724-32
pubmed: 23091172
J Am Heart Assoc. 2021 Jun;10(11):e018549
pubmed: 33998283
Am J Hum Genet. 2011 May 13;88(5):586-98
pubmed: 21565292
Nat Genet. 2021 Feb;53(2):135-142
pubmed: 33495597
Mol Cell. 1999 Feb;3(2):247-53
pubmed: 10078207
Circ Res. 2013 Aug 30;113(6):660-75
pubmed: 23989711
Circulation. 2010 Jul 13;122(2):138-44
pubmed: 20585010
Int J Mol Sci. 2020 Jun 01;21(11):
pubmed: 32492816
Nat Genet. 2006 Aug;38(8):904-9
pubmed: 16862161
Bioinformatics. 2010 Nov 15;26(22):2867-73
pubmed: 20926424
Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1120-5
pubmed: 9448295
J Am Heart Assoc. 2014 Jun 25;3(3):e000790
pubmed: 24965024
Bioinformatics. 2012 Dec 15;28(24):3326-8
pubmed: 23060615
N Engl J Med. 2009 Apr 23;360(17):1699-701
pubmed: 19369661
JAMA Cardiol. 2020 Jan 1;5(1):83-91
pubmed: 31799990
Circulation. 2018 Jun 19;137(25):2716-2726
pubmed: 29915098
Circulation. 2019 Oct 15;140(16):1318-1330
pubmed: 31554410
Front Cardiovasc Med. 2022 Feb 21;9:804788
pubmed: 35265679
J Cardiovasc Magn Reson. 2016 Nov 30;18(1):89
pubmed: 27899132
Sci Rep. 2018 Apr 3;8(1):5572
pubmed: 29615750
Nat Rev Cardiol. 2020 May;17(5):286-297
pubmed: 31605094
Am J Epidemiol. 2002 Nov 1;156(9):871-81
pubmed: 12397006
Science. 2017 Aug 18;357(6352):
pubmed: 28818916
J Am Coll Cardiol. 2015 Mar 31;65(12):1249-1254
pubmed: 25814232
J Am Heart Assoc. 2021 Sep 7;10(17):e019978
pubmed: 34431363
Circ Res. 2021 May 14;128(10):1533-1553
pubmed: 33983830
Circ Cardiovasc Imaging. 2017 Jun;10(6):
pubmed: 28512159
Oncogene. 2002 Sep 19;21(42):6403-12
pubmed: 12226744
J Am Coll Cardiol. 2013 Oct 1;62(14):1280-1287
pubmed: 23871886
Genet Epidemiol. 2011 Dec;35(8):809-22
pubmed: 22125221
Nat Genet. 2021 Feb;53(2):128-134
pubmed: 33495596
N Engl J Med. 2010 Aug 5;363(6):552-63
pubmed: 20818890
Circ Cardiovasc Imaging. 2013 May 1;6(3):373-83
pubmed: 23553570
Cell Syst. 2020 Sep 23;11(3):229-238.e5
pubmed: 32916098
JAMA. 2013 Mar 6;309(9):896-908
pubmed: 23462786
J Biol Chem. 2004 Jan 30;279(5):3807-16
pubmed: 14604992
Curr Cardiovasc Imaging Rep. 2014;7:9287
pubmed: 25152807
Hypertension. 2010 Aug;56(2):225-31
pubmed: 20606113