Satellite RNAs: emerging players in subnuclear architecture and gene regulation.
T2T genome
membraneless organelle
noncoding RNA
satellite DNA
stress response
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
18 09 2023
18 09 2023
Historique:
revised:
13
07
2023
received:
20
04
2023
accepted:
22
07
2023
medline:
19
9
2023
pubmed:
1
8
2023
entrez:
1
8
2023
Statut:
ppublish
Résumé
Satellite DNA is characterized by long, tandemly repeated sequences mainly found in centromeres and pericentromeric chromosomal regions. The recent advent of telomere-to-telomere sequencing data revealed the complete sequences of satellite regions, including centromeric α-satellites and pericentromeric HSat1-3, which together comprise ~ 5.7% of the human genome. Despite possessing constitutive heterochromatin features, these regions are transcribed to produce long noncoding RNAs with highly repetitive sequences that associate with specific sets of proteins to play various regulatory roles. In certain stress or pathological conditions, satellite RNAs are induced to assemble mesoscopic membraneless organelles. Specifically, under heat stress, nuclear stress bodies (nSBs) are scaffolded by HSat3 lncRNAs, which sequester hundreds of RNA-binding proteins. Upon removal of the stressor, nSBs recruit additional regulatory proteins, including protein kinases and RNA methylases, which modify the previously sequestered nSB components. The sequential recruitment of substrates and enzymes enables nSBs to efficiently regulate the splicing of hundreds of pre-mRNAs under limited temperature conditions. This review discusses the structural features and regulatory roles of satellite RNAs in intracellular architecture and gene regulation.
Identifiants
pubmed: 37526230
doi: 10.15252/embj.2023114331
pmc: PMC10505914
doi:
Substances chimiques
RNA, Satellite
0
Transcription Factors
0
DNA, Satellite
0
Heterochromatin
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e114331Informations de copyright
© 2023 The Authors. Published under the terms of the CC BY 4.0 license.
Références
Hum Mol Genet. 2009 Sep 1;18(17):3178-93
pubmed: 19482874
Science. 2022 Apr;376(6588):44-53
pubmed: 35357919
Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1979-84
pubmed: 22308327
Science. 2022 Apr;376(6588):eabl4178
pubmed: 35357911
Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):31891-31901
pubmed: 33257565
Int J Mol Sci. 2020 Apr 17;21(8):
pubmed: 32316575
Nature. 2004 Feb 5;427(6974):553-8
pubmed: 14765198
Mol Cell. 2018 Nov 1;72(3):525-540.e13
pubmed: 30318443
Genome Res. 2020 Sep;30(9):1291-1305
pubmed: 32801147
Cell. 1994 Aug 12;78(3):487-98
pubmed: 7520368
Trends Biochem Sci. 2009 Mar;34(3):146-53
pubmed: 19208481
Mol Cell Biol. 2002 Apr;22(7):2229-41
pubmed: 11884609
Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4304-9
pubmed: 25831520
J Cell Biol. 1987 Apr;104(4):805-15
pubmed: 3558482
Proc Natl Acad Sci U S A. 2021 Aug 31;118(35):
pubmed: 34426493
Curr Opin Cell Biol. 2020 Jun;64:67-76
pubmed: 32259767
Nat Genet. 2011 Mar;43(3):220-7
pubmed: 21317888
Science. 2011 Feb 4;331(6017):593-6
pubmed: 21233348
Mol Cell Biol. 1993 Mar;13(3):1392-407
pubmed: 8441385
Science. 2001 Oct 5;294(5540):109-15
pubmed: 11588252
Biochem Biophys Res Commun. 2012 Feb 3;418(1):149-55
pubmed: 22244871
BMC Biol. 2023 Feb 8;21(1):28
pubmed: 36755311
J Cell Biol. 2011 Oct 3;195(1):27-40
pubmed: 21949414
BMC Genomics. 2019 May 31;20(1):439
pubmed: 31151386
Mol Biol Cell. 2002 Jun;13(6):2069-79
pubmed: 12058070
Genes Dev. 2015 Jan 1;29(1):63-80
pubmed: 25561496
Nat Commun. 2019 Jan 9;10(1):90
pubmed: 30626867
Nucleic Acids Res. 1982 Jan 22;10(2):547-63
pubmed: 6278420
Cold Spring Harb Symp Quant Biol. 2019;84:227-237
pubmed: 32019862
Cold Spring Harb Perspect Biol. 2010 Jun;2(6):a000695
pubmed: 20516127
Neuron. 2017 Apr 5;94(1):108-124.e7
pubmed: 28343865
J Cell Sci. 2004 Sep 1;117(Pt 19):4551-8
pubmed: 15331664
Nucleic Acids Res. 1976 Nov;3(11):3063-76
pubmed: 794832
J Cell Biol. 2004 Jan 5;164(1):25-33
pubmed: 14699086
Science. 2013 May 31;340(6136):1110-3
pubmed: 23723239
Genome Res. 2007 Aug;17(8):1146-60
pubmed: 17623812
J Cell Biol. 2002 Mar 4;156(5):775-81
pubmed: 11877455
Elife. 2017 Aug 01;6:
pubmed: 28760200
Biochem Biophys Res Commun. 2019 Aug 20;516(2):419-423
pubmed: 31227213
J Mol Biol. 1961 Dec;3:711-6
pubmed: 14456492
Science. 2018 Jun 8;360(6393):
pubmed: 29880660
J Cell Sci. 2000 Oct;113 Pt 19:3485-97
pubmed: 10984439
JCI Insight. 2016 Jun 2;1(8):e86646
pubmed: 27699267
Nucleic Acids Res. 2008 Feb;36(2):423-34
pubmed: 18039709
Mol Biol Cell. 2001 Nov;12(11):3502-14
pubmed: 11694584
Nat Rev Mol Cell Biol. 2016 Jan;17(1):16-29
pubmed: 26601620
Nature. 2011 Sep 07;477(7363):179-84
pubmed: 21901007
Nature. 2013 Jul 11;499(7457):172-7
pubmed: 23846655
Neuron. 2016 Dec 21;92(6):1266-1278
pubmed: 28009274
Nucleic Acids Res. 1984 Mar 26;12(6):2887-900
pubmed: 6324132
Elife. 2020 Nov 11;9:
pubmed: 33174837
Cell Rep. 2017 Mar 21;18(12):2943-2956
pubmed: 28329686
Nat Genet. 2002 Mar;30(3):329-34
pubmed: 11850619
Dev Cell. 2017 Aug 7;42(3):226-240.e6
pubmed: 28787590
Genome Res. 2016 Sep;26(9):1178-87
pubmed: 27384170
Nat Commun. 2021 Jan 11;12(1):236
pubmed: 33431896
Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15148-53
pubmed: 26575630
Genes Cells. 2014 Jun;19(6):528-38
pubmed: 24750444
Nucleic Acids Res. 2017 Jan 9;45(1):382-394
pubmed: 27536004
Mol Cells. 2017 Dec 31;40(12):889-896
pubmed: 29276943
EMBO J. 2020 Feb 3;39(3):e102729
pubmed: 31782550
J Cell Biol. 2014 Nov 10;207(3):335-49
pubmed: 25365994
Mol Biol Cell. 2005 Jun;16(6):2597-604
pubmed: 15788562
J Mol Biol. 1967 Feb 14;23(3):619-22
pubmed: 6032194
Cold Spring Harb Perspect Biol. 2014 Nov 20;7(1):a015818
pubmed: 25414369
Noncoding RNA. 2020 Feb 20;6(1):
pubmed: 32093161
Semin Cell Dev Biol. 2022 Aug;128:2-14
pubmed: 35487859
Elife. 2014 Jul 15;3:e02137
pubmed: 25027692
Int J Mol Sci. 2021 Apr 21;22(9):
pubmed: 33919233
Nat Rev Mol Cell Biol. 2014 Nov;15(11):723-34
pubmed: 25303116
Elife. 2014 Aug 12;3:e03254
pubmed: 25117489
J Cell Sci. 2016 Oct 1;129(19):3541-3552
pubmed: 27528402
Genes (Basel). 2021 Sep 28;12(10):
pubmed: 34680920
Cell. 2014 Feb 27;156(5):907-19
pubmed: 24581492
Int J Mol Sci. 2021 May 07;22(9):
pubmed: 34067147
Science. 2001 Feb 16;291(5507):1304-51
pubmed: 11181995
Gene Expr. 1999;7(4-6):261-70
pubmed: 10440227
Int J Mol Sci. 2023 Feb 03;24(3):
pubmed: 36769294
Genes Dev. 2008 Aug 1;22(15):2048-61
pubmed: 18676810
Elife. 2019 Nov 05;8:
pubmed: 31687931
Nat Cell Biol. 2013 Dec;15(12):1495-506
pubmed: 24270890
EMBO J. 2021 Aug 2;40(15):e107976
pubmed: 34184765
Mol Cell. 2018 Jun 7;70(5):842-853.e7
pubmed: 29861157
J Cell Sci. 2000 Nov;113 ( Pt 22):4043-53
pubmed: 11058091
Cell Rep. 2018 Apr 10;23(2):512-521
pubmed: 29642008
Microbiol Mol Biol Rev. 2008 Dec;72(4):686-727
pubmed: 19052325
Mol Biol Cell. 2004 Feb;15(2):543-51
pubmed: 14617804
Chromosoma. 2021 Mar;130(1):75-90
pubmed: 33585981
Mol Biol Cell. 2023 Apr 1;34(4):br5
pubmed: 36753381
Hum Genet. 2001 Oct;109(4):452-62
pubmed: 11702227
Cytogenet Genome Res. 2007;118(1):42-54
pubmed: 17901699
Dev Cell. 2010 Oct 19;19(4):625-38
pubmed: 20951352
Nature. 2001 Feb 15;409(6822):860-921
pubmed: 11237011
J Cell Biol. 1989 Nov;109(5):1921-35
pubmed: 2681223
Genes Dev. 2013 Apr 15;27(8):859-72
pubmed: 23599346
Nat Rev Mol Cell Biol. 2021 Sep;22(9):589-607
pubmed: 34140671
Am J Hum Genet. 2009 Nov;85(5):544-57
pubmed: 19878914
Nat Rev Mol Cell Biol. 2023 Apr;24(4):288-304
pubmed: 36424481
Nat Commun. 2022 Jun 20;13(1):3525
pubmed: 35725842
Chromosome Res. 2018 Mar;26(1-2):5-23
pubmed: 29332159
Mol Cell. 2018 Jun 7;70(5):854-867.e9
pubmed: 29883606
J Cell Biol. 2013 Dec 23;203(6):929-42
pubmed: 24344186
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2525-30
pubmed: 19188602
EMBO J. 2023 Sep 18;42(18):e114331
pubmed: 37526230
Int J Mol Sci. 2021 Feb 19;22(4):
pubmed: 33669810
Hum Mol Genet. 2019 Dec 1;28(23):3997-4011
pubmed: 31630170
Neuropathology. 2013 Dec;33(6):600-11
pubmed: 23607545
J Mol Biol. 1986 Jan 20;187(2):145-55
pubmed: 3701863