Menopausal hormone therapy and change in physical activity in the Women's Health Initiative hormone therapy clinical trials.

The menopausal transition results in a progressive decrease in circulating estrogen levels. Experimental evidence in rodents has indicated that estrogen depletion leads to a reduction of energy expenditure and physical activity. It is unclear whether treatment with estrogen therapy increases physical activity level in postmenopausal women. A total of 27,327 postmenopausal women aged 50-79 years enrolled in the Women's Health Initiative randomized double-blind trials of menopausal hormone therapy. Self-reported leisure-time physical activity at baseline, and years 1, 3, and 6 was quantified as metabolic equivalents (MET)-h/wk. In each trial, comparison between intervention and placebo groups of changes in physical activity levels from baseline to follow-up assessment was examined using linear regression models. In the CEE-alone trial, the increase in MET-h/wk was greater in the placebo group compared with the intervention group at years 3 ( P = 0.002) and 6 ( P < 0.001). Similar results were observed when analyses were restricted to women who maintained an adherence rate ≥80% during the trial or who were physically active at baseline. In the CEE + MPA trial, the primary analyses did not show significant differences between groups, but the increase of MET-h/wk was greater in the placebo group compared with the intervention group at year 3 ( P = 0.004) among women with an adherence rate ≥80%. The results from this clinical trial do not support the hypothesis that estrogen treatment increases physical activity among postmenopausal women.

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Copyright © 2023 by The North American Menopause Society.

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Conflict of interest/financial disclosures: R.T.C. receives ongoing funding from UpToDate . M.S.L. received $1000 honorarium from the New England Bone Club for a plenary lecture at the 2022 New England Bone Club meeting. The other authors have nothing to disclose.