Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy.

Humans Animals Mice Atherosclerosis / metabolism Autophagy / genetics Apolipoproteins E / genetics Lipids CARD Signaling Adaptor Proteins / metabolism Mice, Knockout Mice, Inbred C57BL

Journal

Nature communications

ISSN: 2041-1723

Titre abrégé: Nat Commun

Pays: England

ID NLM: 101528555

Informations de publication

Date de publication:
01 08 2023

Historique:

received: 27 09 2022

accepted: 17 07 2023

medline: 3 8 2023

pubmed: 2 8 2023

entrez: 1 8 2023

Statut: epublish

Résumé

Caspase recruitment-domain containing protein 9 (CARD9) is a key signaling pathway in macrophages but its role in atherosclerosis is still poorly understood. Global deletion of Card9 in Apoe

Identifiants

DOI: 10.1038/s41467-023-40216-x PMID: 37528097 PMC: PMC10394049

pubmed: 37528097

doi: 10.1038/s41467-023-40216-x

pii: 10.1038/s41467-023-40216-x

pmc: PMC10394049

doi:

Substances chimiques

Apolipoproteins E 0

Lipids 0

CARD Signaling Adaptor Proteins 0

CARD9 protein, human 0

Card9 protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

4622

Subventions

Organisme : NIAID NIH HHS

ID : R01 AI127564

Pays : United States

Organisme : British Heart Foundation

Pays : United Kingdom

Informations de copyright

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