Caudate volume and symptoms of apathy in older adults with multiple sclerosis.

Humans Aged Middle Aged Apathy Multiple Sclerosis / diagnosis Brain Caudate Nucleus / diagnostic imaging Magnetic Resonance Imaging
Multiple sclerosis aging apathy caudate magnetic resonance imaging

Journal

Multiple sclerosis (Houndmills, Basingstoke, England)
ISSN: 1477-0970
Titre abrégé: Mult Scler
Pays: England
ID NLM: 9509185

Informations de publication

Date de publication:
09 2023
Historique:
medline: 15 9 2023
pubmed: 2 8 2023
entrez: 2 8 2023
Statut: ppublish

Résumé

Apathy is common in multiple sclerosis (MS) and neurological disease, but its presence and underlying brain mechanisms in older adults with MS (OAMS) have not been evaluated. Examine apathy and its association with caudate nuclei volume in OAMS and controls. We hypothesized that compared to controls, OAMS would demonstrate: a) greater apathy; b) stronger associations between apathy and caudate nuclei volumes. OAMS ( OAMS reported greater apathy compared to controls ( Caudate nuclei, which are susceptible to adverse MS effects and implicated in mediating cognitive and motor function, may influence the presence and severity of apathy in OAMS.

Sections du résumé

BACKGROUND
Apathy is common in multiple sclerosis (MS) and neurological disease, but its presence and underlying brain mechanisms in older adults with MS (OAMS) have not been evaluated.
OBJECTIVE
Examine apathy and its association with caudate nuclei volume in OAMS and controls. We hypothesized that compared to controls, OAMS would demonstrate: a) greater apathy; b) stronger associations between apathy and caudate nuclei volumes.
METHODS
OAMS (
RESULTS
OAMS reported greater apathy compared to controls (
CONCLUSION
Caudate nuclei, which are susceptible to adverse MS effects and implicated in mediating cognitive and motor function, may influence the presence and severity of apathy in OAMS.

Identifiants

DOI: 10.1177/13524585231188096 PMID: 37528586
pubmed: 37528586
doi: 10.1177/13524585231188096
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1266-1274

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS109023
Pays : United States

Auteurs

Sarah E Cote (SE)

Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA.
ORCID: 0000-0003-3640-7358

Mark E Wagshul (ME)

Department of Radiology, Gruss Magnetic Resonance Research Center, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
ORCID: 0000-0002-2258-6933

Fredrick W Foley (FW)

Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA.
ORCID: 0000-0003-1529-8842

Michael L Lipton (ML)

Department of Radiology, Gruss Magnetic Resonance Research Center, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA/.
Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA.
Department of Psychiatry and Behavioral Sciences, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Department of Psychiatry Radiology, Columbia University Irving Medical Center, New York, NY, USA.

Roee Holtzer (R)

Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA/.
Department of Neurology Albert Einstein College of Medicine, Bronx, NY, USA.
ORCID: 0000-0001-6639-0724

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Caudate volume and symptoms of apathy in older...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Caudate volume and symptoms of apathy in older...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Caudate volume and symptoms of apathy in older...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Apathie › Caudate volume and symptoms of apathy in older...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Caudate volume and symptoms of apathy in older...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Caudate volume and symptoms of apathy in older...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Néostriatum › Noyau caudé › Caudate volume and symptoms of apathy in older...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Caudate volume and symptoms of apathy in older...