A Conformationally Restricted Gold(III) Complex Elicits Antiproliferative Activity in Cancer Cells.

Female Humans Gold / pharmacology Antineoplastic Agents / chemistry Cell Line, Tumor Ovarian Neoplasms Crystallography, X-Ray Diamines / chemistry Norbornanes Ligands

Journal

Inorganic chemistry
ISSN: 1520-510X
Titre abrégé: Inorg Chem
Pays: United States
ID NLM: 0366543

Informations de publication

Date de publication:
14 Aug 2023
Historique:
medline: 15 8 2023
pubmed: 2 8 2023
entrez: 2 8 2023
Statut: ppublish

Résumé

Diamine ligands are effective structural scaffolds for tuning the reactivity of transition-metal complexes for catalytic, materials, and phosphorescent applications and have been leveraged for biological use. In this work, we report the synthesis and characterization of a novel class of cyclometalated [C^N] Au(III) complexes bearing secondary diamines including a norbornane backbone, (2

Identifiants

DOI: 10.1021/acs.inorgchem.3c02066 PMID: 37530672
pubmed: 37530672
doi: 10.1021/acs.inorgchem.3c02066
doi:

Substances chimiques

Gold 7440-57-5
Antineoplastic Agents 0
Diamines 0
Norbornanes 0
Ligands 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

13118-13129

Auteurs

Sailajah Gukathasan (S)

Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.

Oluwatosin A Obisesan (OA)

Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.

Setareh Saryazdi (S)

Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.

Libby Ratliff (L)

Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.
ORCID: 0000-0002-0187-9921

Sean Parkin (S)

Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.

Robert B Grossman (RB)

Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.
ORCID: 0000-0001-8866-3754

Samuel G Awuah (SG)

Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.
Center for Pharmaceutical Research and Innovation and Department of Pharmaceutical Sciences, College of Pharmacy University of Kentucky, Lexington, Kentucky 40536, United States.
Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536, United States.
ORCID: 0000-0003-4947-7283

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A Conformationally Restricted Gold(III)...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Or › A Conformationally Restricted Gold(III)...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › A Conformationally Restricted Gold(III)...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › A Conformationally Restricted Gold(III)...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › A Conformationally Restricted Gold(III)...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › A Conformationally Restricted Gold(III)...
questionsmedicales.fr › Composés chimiques organiques › Amines › Polyamines › Diamines › A Conformationally Restricted Gold(III)...
questionsmedicales.fr › Composés polycycliques › Composés pontés › Composés bicycliques pontés › Monoterpènes de type norbornane › A Conformationally Restricted Gold(III)...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › A Conformationally Restricted Gold(III)...