Oral follicle-stimulating hormone receptor agonist affects granulosa cells differently than recombinant human FSH.
FSH receptor
IVF
PCOS
allosteric agonist
granulosa cells
Journal
Fertility and sterility
ISSN: 1556-5653
Titre abrégé: Fertil Steril
Pays: United States
ID NLM: 0372772
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
28
02
2023
revised:
25
07
2023
accepted:
26
07
2023
pmc-release:
01
11
2024
medline:
30
10
2023
pubmed:
3
8
2023
entrez:
2
8
2023
Statut:
ppublish
Résumé
To determine whether TOP5300, a novel oral follicle-stimulating hormone (FSH) receptor (FSHR) allosteric agonist, elicits a different cellular response than recombinant human FSH (rh-FSH) in human granulosa cells from patients undergoing in vitro fertilization. Basic science research with a preclinical allosteric FSHR agonist. University hospital. Patients with infertility at a single academic fertility clinic were recruited under an Institutional Review Board-approved protocol. Primary granulosa cell cultures were established for 41 patients, of whom 8 had normal ovarian reserve (NOR), 17 were of advanced reproductive age (ARA), 12 had a diagnosis of polycystic ovary syndrome (PCOS), and 4 had a combination of diagnoses, such as ARA and PCOS. Primary granulosa-lutein (GL) cell cultures were treated with rh-FSH, TOP5300, or vehicle. Estradiol (E TOP5300 consistently stimulated E TOP5300 appears to stimulate E
Identifiants
pubmed: 37532169
pii: S0015-0282(23)00718-5
doi: 10.1016/j.fertnstert.2023.07.024
pmc: PMC10659100
mid: NIHMS1921767
pii:
doi:
Substances chimiques
Receptors, FSH
0
Follicle Stimulating Hormone, Human
0
Aromatase
EC 1.14.14.1
Follicle Stimulating Hormone
9002-68-0
Gonadal Steroid Hormones
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1061-1070Subventions
Organisme : NCI NIH HHS
ID : P30 CA125123
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK056338
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES030285
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD032067
Pays : United States
Informations de copyright
Copyright © 2023 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests J.Z.G. reports funding from NIH R01 HD032067 and Baylor College of Medicine Department of Obstetrics and Gynecology for the submitted work. D.M. has nothing to disclose. H.Y. is the Chief executive officer and reports stock options from CanWell Pharma. F.S.S. has nothing to disclose. H.L.J. has nothing to disclose. W.E.G. has nothing to disclose. M.M.M. has nothing to disclose. S.P. has nothing to disclose.
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