Comparison of homocitrulline and carbamylated albumin as biomarkers of carbamylation reactions in hemodialyzed patients.
Carbamylation
End-stage kidney disease
Homocitrulline
Journal
Amino acids
ISSN: 1438-2199
Titre abrégé: Amino Acids
Pays: Austria
ID NLM: 9200312
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
01
12
2022
accepted:
18
07
2023
medline:
4
12
2023
pubmed:
3
8
2023
entrez:
2
8
2023
Statut:
ppublish
Résumé
To describe the association between levels of homocitrulline (HCit) and the degree of albumin carbamylation in a cohort of hemodialyzed patients. Plasma total and protein-bound HCit concentrations in samples from hemodialyzed patients included in NICOREN trial were determined by LC-MS/MS at baseline and after 24 weeks of treatment with either sevelamer or nicotinamide. HCit concentrations at all timepoints and in both groups were positively and significantly correlated with the degree of albumin carbamylation. Plasma concentrations of total HCit, protein-bound HCit and carbamylated albumin did not decrease after 24 weeks of treatment with either sevelamer or nicotinamide. The present results demonstrate that plasma total and protein-bound HCit concentrations were closely associated with albumin carbamylation in hemodialyzed patients. Therefore, total and protein-bound HCit concentrations might be valuable biomarkers of the overall intensity of protein carbamylation in this context. Given the less complex and time-consuming analytical methods required, these markers should be favored in future clinical studies of carbamylation reaction.
Identifiants
pubmed: 37532908
doi: 10.1007/s00726-023-03306-0
pii: 10.1007/s00726-023-03306-0
pmc: PMC10689527
doi:
Substances chimiques
Albumins
0
Biomarkers
0
homocitrulline
1190-49-4
Niacinamide
25X51I8RD4
Sevelamer
9YCX42I8IU
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1455-1460Informations de copyright
© 2023. The Author(s).
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