CD36 genetic polymorphism and salivary cues are associated with oleic acid sensitivity and dietary fat intake.
CD36
lipid sensing
lipopolysaccharide
non-vegetarian
obesity
polymorphism
Journal
Nutrition bulletin
ISSN: 1467-3010
Titre abrégé: Nutr Bull
Pays: England
ID NLM: 9315625
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
revised:
07
07
2023
received:
26
02
2023
accepted:
17
07
2023
medline:
21
8
2023
pubmed:
3
8
2023
entrez:
3
8
2023
Statut:
ppublish
Résumé
There is a lack of research on the combined effects of genetic variations (specifically CD36 SNPs-rs1761667 and rs1527483), dietary food habits (vegetarian or not), and the salivary environment on obesity and taste sensitivity, especially in the Indian population. The current study aims to better understand the relationship between impaired taste perception, fat consumption, higher BMI and obesity development by examining the combined association between CD36 SNPs, oleic acid (OA) detection threshold, and food habits among Indian participants. Furthermore, the relationship between oral fatty acid (FAs) sensitivity and taste physiology factors linked to inflammation and salivary proteins was considered. Participants with the minor allele (AA/AG) of CD36 (in both rs1527483 and rs1761667) consumed more fat, particularly saturated FAs (p = 0.0351). Salivary lipopolysaccharide, which causes inflammation, was significantly greater in non-vegetarians with a higher BMI (p < 0.05), and it exhibited a negative correlation (r = -0.232 and p < 0.05) with Ki67 gene expression, a marker for taste progenitor cells. A positive correlation (r = 0.474, p = 0.04) between TLR4 mRNA levels and the OA detection threshold was also observed. Participants with BMI > 25 kg/m
Substances chimiques
Oleic Acid
2UMI9U37CP
Dietary Fats
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
376-389Informations de copyright
© 2023 British Nutrition Foundation.
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