Frequency and imaging correlates of neuropsychiatric symptoms in Progressive Supranuclear Palsy.


Journal

Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341

Informations de publication

Date de publication:
10 2023
Historique:
received: 01 06 2023
accepted: 20 07 2023
medline: 6 9 2023
pubmed: 3 8 2023
entrez: 3 8 2023
Statut: ppublish

Résumé

Neuropsychiatric symptoms are intrinsic to Progressive Supranuclear Palsy (PSP) and a spoonful of studies investigated their imaging correlates. Describe (I) the frequency and severity of neuropsychiatric symptoms in PSP and (II) their structural imaging correlates. Twenty-six PSP patients underwent Neuropsychiatric Inventory (NPI) and brain 3D T1-weighted MRI. Spearman's rho with Bonferroni correction was used to investigate correlations between NPI scores and volumes of gray matter regions. More than 80% of patients presented at least one behavioral symptom of any severity. The most frequent and severe were depression/dysphoria, apathy, and irritability/lability. Significant relationships were found between the severity of irritability and right pars opercularis volume (p < 0.001) as well as between the frequency of agitation/aggression and left lateral occipital volume (p < 0.001). Depression, apathy, and irritability are the most common neuropsychiatric symptoms in PSP. Moreover, we found a relationship between specific positive symptoms as irritability and agitation/aggression and greater volume of the right pars opercularis cortex and lower volume of the left occipital cortex, respectively, which deserve further investigations.

Identifiants

pubmed: 37535119
doi: 10.1007/s00702-023-02676-9
pii: 10.1007/s00702-023-02676-9
pmc: PMC10480260
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1259-1267

Informations de copyright

© 2023. The Author(s).

Références

J Geriatr Psychiatry Neurol. 2022 May;35(3):280-292
pubmed: 33567955
Mov Disord. 2006 May;21(5):632-8
pubmed: 16353177
Psychiatry Res. 2013 Dec 30;210(3):1205-10
pubmed: 24035530
Nat Neurosci. 2006 Jan;9(1):28-30
pubmed: 16327784
J Affect Disord. 2015 Nov 1;186:110-8
pubmed: 26233321
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11050-5
pubmed: 10984517
J Neuropsychiatry Clin Neurosci. 2001 Winter;13(1):42-9
pubmed: 11207328
Science. 1999 Dec 24;286(5449):2526-8
pubmed: 10617472
Brain Behav. 2021 Oct;11(10):e2344
pubmed: 34492729
Mov Disord. 2019 Aug;34(8):1228-1232
pubmed: 30884545
Neurol Sci. 2023 Jan;44(1):159-170
pubmed: 36169756
Mov Disord. 2017 Jun;32(6):853-864
pubmed: 28467028
Mov Disord. 2018 Aug;33(8):1361-1365
pubmed: 29984518
J Neuropsychiatry Clin Neurosci. 2018 Winter;30(1):38-44
pubmed: 28506191
Brain. 2007 Jun;130(Pt 6):1552-65
pubmed: 17405767
Neurol Sci. 2015 Apr;36(4):585-91
pubmed: 25380622
J Neurosci. 2016 Apr 06;36(14):4038-49
pubmed: 27053210
Neurosci Biobehav Rev. 2009 May;33(5):631-46
pubmed: 18835296
Mol Psychiatry. 2012 Apr;17(4):412-20
pubmed: 21321565
Neurology. 1996 Nov;47(5):1184-9
pubmed: 8909427
J Neurol Neurosurg Psychiatry. 1998 Nov;65(5):717-21
pubmed: 9810944
J Psychiatry Neurosci. 2015 Sep;40(5):316-24
pubmed: 25853284
Neurol Sci. 2022 Aug;43(8):4803-4809
pubmed: 35411501
Biol Psychiatry. 2017 Apr 15;81(8):718-727
pubmed: 28031150
J Alzheimers Dis. 2018;65(1):147-163
pubmed: 30010122
J Neurol. 2018 Nov;265(11):2602-2613
pubmed: 30178175
Biol Psychiatry. 2013 Jan 15;73(2):144-52
pubmed: 22818781
Neuron. 2003 Sep 11;39(6):1053-8
pubmed: 12971903
Mov Disord. 2011 Feb 15;26(3):493-8
pubmed: 21462261
Eur Arch Psychiatry Clin Neurosci. 2013 Oct;263(7):593-606
pubmed: 23381548
Psychosomatics. 1995 Nov-Dec;36(6):550-4
pubmed: 7501785
Mov Disord. 2010 Jun 15;25(8):1077-81
pubmed: 20535826
Neurology. 2018 Mar 20;90(12):e1066-e1076
pubmed: 29453244
Neurology. 2019 Aug 6;93(6):235-236
pubmed: 31270221
Biol Psychiatry. 2010 Dec 15;68(12):1141-7
pubmed: 20801427
BMC Geriatr. 2021 Mar 5;21(1):160
pubmed: 33663416
J Neurol. 2022 Jul;269(7):3522-3528
pubmed: 34997852
Neuroimage. 1999 Feb;9(2):179-94
pubmed: 9931268
Soc Neurosci. 2013;8(2):108-11
pubmed: 23410514
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
J Cogn Neurosci. 1993 Spring;5(2):162-76
pubmed: 23972151
Neurology. 1994 Dec;44(12):2308-14
pubmed: 7991117
Brain Sci. 2019 Dec 13;9(12):
pubmed: 31847131
J Psychiatr Res. 2013 Dec;47(12):1955-66
pubmed: 24070910
Psychogeriatrics. 2011 Mar;11(1):54-9
pubmed: 21447110
Mov Disord Clin Pract. 2021 Dec 31;9(2):212-217
pubmed: 35146060
Mov Disord. 2006 Feb;21(2):199-207
pubmed: 16200534
Eur J Neurol. 2018 Mar;25(3):469-e32
pubmed: 29114969
J Behav Addict. 2019 Mar 1;8(1):162-168
pubmed: 30663329
Psychiatry Res Neuroimaging. 2016 Feb 28;248:64-72
pubmed: 26778367
Dement Neuropsychol. 2013 Jul-Sep;7(3):236-243
pubmed: 29213845
IEEE Trans Med Imaging. 2001 Jan;20(1):70-80
pubmed: 11293693
Front Aging Neurosci. 2022 Apr 01;14:851788
pubmed: 35431891
Bipolar Disord. 2012 Mar;14(2):135-45
pubmed: 22420589
J Alzheimers Dis. 2015;50(3):839-45
pubmed: 26836181
Brain. 2017 Jun 1;140(6):1792-1807
pubmed: 28486594
Neuron. 2002 Jan 31;33(3):341-55
pubmed: 11832223
Brain Nerve. 2018 Sep;70(9):961-970
pubmed: 30177574
Trends Cogn Sci. 2014 Apr;18(4):177-85
pubmed: 24440116
Zhonghua Yi Xue Za Zhi. 2021 Sep 21;101(35):2792-2797
pubmed: 34551496
Neuroimage. 1999 Feb;9(2):195-207
pubmed: 9931269

Auteurs

Sofia Cuoco (S)

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Neuroscience Section, Via Allende, 84081, Baronissi (Salerno), Italy.

Sara Ponticorvo (S)

Center for Magnetic Resonance Research (CMRR), Department of Radiology, University of Minnesota, 2021 6th St. SE, Minneapolis, MN, 55455, USA.

Filomena Abate (F)

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Neuroscience Section, Via Allende, 84081, Baronissi (Salerno), Italy.

Maria Francesca Tepedino (MF)

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Neuroscience Section, Via Allende, 84081, Baronissi (Salerno), Italy.

Roberto Erro (R)

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Neuroscience Section, Via Allende, 84081, Baronissi (Salerno), Italy.

Renzo Manara (R)

Department of Neurosciences, Neuroradiology Unit, University of Padua, 35128, Padua, Italy.

Gianfranco Di Salle (G)

Scuola Superiore Di Studi Universitari E Perfezionamento Sant'Anna, Classe Di Scienze Sperimentali, Pisa, Italy.

Francesco Di Salle (F)

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Neuroscience Section, Via Allende, 84081, Baronissi (Salerno), Italy.

Maria Teresa Pellecchia (MT)

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Neuroscience Section, Via Allende, 84081, Baronissi (Salerno), Italy.

Fabrizio Esposito (F)

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138, Naples, Italy.

Paolo Barone (P)

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Neuroscience Section, Via Allende, 84081, Baronissi (Salerno), Italy.

Marina Picillo (M)

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Center for Neurodegenerative Diseases (CEMAND), University of Salerno, Neuroscience Section, Via Allende, 84081, Baronissi (Salerno), Italy. mpicillo@unisa.it.

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