Repeated seizures lead to progressive ventilatory dysfunction in SS
SUDEP
breathing variability
respiratory depression
seizures
serotonin
Journal
Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
Titre abrégé: J Appl Physiol (1985)
Pays: United States
ID NLM: 8502536
Informations de publication
Date de publication:
01 10 2023
01 10 2023
Historique:
pmc-release:
01
10
2024
medline:
23
10
2023
pubmed:
3
8
2023
entrez:
3
8
2023
Statut:
ppublish
Résumé
Patients with uncontrolled epilepsy experience repeated seizures putting them at increased risk for sudden unexpected death in epilepsy (SUDEP). Data from human patients have led to the hypothesis that SUDEP results from severe cardiorespiratory suppression after a seizure, which may involve pathological deficiencies in the brainstem serotonin (5-HT) system. Rats with a genomic
Identifiants
pubmed: 37535709
doi: 10.1152/japplphysiol.00072.2023
pmc: PMC10642517
doi:
Substances chimiques
Serotonin
333DO1RDJY
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
872-885Subventions
Organisme : BLRD VA
ID : I01 BX004024
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122358
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135749
Pays : United States
Organisme : NIDDK NIH HHS
ID : F31 DK122647
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK126720
Pays : United States
Références
Expert Rev Neurother. 2016 May;16(5):561-72
pubmed: 27029803
Eur J Neurosci. 2000 Jul;12(7):2623-33
pubmed: 10947836
Epilepsia. 2023 Oct 19;:
pubmed: 37857465
Seizure. 2018 Dec;63:7-13
pubmed: 30391664
JCI Insight. 2017 Sep 21;2(18):
pubmed: 28931751
Curr Opin Neurol. 2019 Apr;32(2):205-212
pubmed: 30694923
Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14490-5
pubmed: 20651251
Neurochem Res. 2017 Jul;42(7):1873-1888
pubmed: 28290134
IEEE Trans Biomed Eng. 2001 Nov;48(11):1342-7
pubmed: 11686633
Lancet. 2016 Oct 8;388(10053):1545-1602
pubmed: 27733282
Immunity. 2019 Mar 19;50(3):764-766
pubmed: 30893590
Brain. 2018 Jun 1;141(6):1719-1733
pubmed: 29608654
J Appl Physiol (1985). 1988 Jul;65(1):309-17
pubmed: 3403474
Handb Exp Pharmacol. 2021;267:277-356
pubmed: 34345939
J Neurosci Res. 2000 Apr 15;60(2):266-79
pubmed: 10740232
Neurobiol Dis. 2008 Jan;29(1):142-60
pubmed: 17931873
J Appl Physiol (1985). 2010 May;108(5):1425-32
pubmed: 20133432
Epilepsia. 2016 Jan;57 Suppl 1:35-45
pubmed: 26749015
J Neurol Neurosurg Psychiatry. 2000 Feb;68(2):211-3
pubmed: 10644790
Epilepsia. 2006 Jan;47(1):21-6
pubmed: 16417527
Epilepsia. 2019 Mar;60(3):508-517
pubmed: 30756391
Cereb Cortex. 2017 Feb 1;27(2):933-949
pubmed: 28158484
Epilepsia. 2011 Jun;52(6):1150-9
pubmed: 21671925
Epilepsy Behav. 2017 Jun;71(Pt B):174-180
pubmed: 26272185
Eur J Hum Genet. 2021 Oct;29(10):1566-1569
pubmed: 33840812
Epilepsia. 2011 Jan;52 Suppl 1:28-38
pubmed: 21214537
N Engl J Med. 2009 May 7;360(19):1960-70
pubmed: 19420365
PLoS One. 2019 Oct 21;14(10):e0223468
pubmed: 31634345
FASEB J. 2019 Apr;33(4):5067-5075
pubmed: 30605394
J Am Soc Nephrol. 2021 Jun 1;32(6):1498-1512
pubmed: 33811157
Brain. 2008 Dec;131(Pt 12):3239-45
pubmed: 18952672
Front Neurol. 2020 Dec 23;11:626658
pubmed: 33424762
Neurobiol Dis. 2004 Jul;16(2):321-34
pubmed: 15193289
Respir Physiol Neurobiol. 2013 Apr 1;186(2):221-8
pubmed: 23454023
Epilepsia Open. 2022 Jun;7(2):280-292
pubmed: 34826216
J Neuroinflammation. 2017 Jun 23;14(1):125
pubmed: 28645297
J Neurosci. 2015 Jul 15;35(28):10281-9
pubmed: 26180203
Respir Physiol. 1984 Dec;58(3):245-51
pubmed: 6528102
Lancet Neurol. 2013 Oct;12(10):966-77
pubmed: 24012372
Epilepsy Behav. 2021 Aug;121(Pt B):106440
pubmed: 31399338
Handb Clin Neurol. 2022;189:153-176
pubmed: 36031303
Cells. 2018 Mar 28;7(4):
pubmed: 29597334
J Appl Physiol (1985). 2011 Jul;111(1):272-84
pubmed: 21527661
Physiol Rep. 2016 Sep;4(17):
pubmed: 27597768
Epilepsia. 2012 Feb;53(2):227-33
pubmed: 22191982
Am J Physiol Renal Physiol. 2020 Feb 1;318(2):F332-F337
pubmed: 31841387
Epilepsia. 2013 May;54 Suppl 2:1-4
pubmed: 23646961
Science. 1991 Nov 1;254(5032):726-9
pubmed: 1683005
Am J Physiol Cell Physiol. 2022 Sep 1;323(3):C706-C717
pubmed: 35848616
Electroencephalogr Clin Neurophysiol. 1972 Mar;32(3):281-94
pubmed: 4110397
Epilepsia. 2018 Mar;59(3):573-582
pubmed: 29336036
J Neurosci. 2002 Dec 15;22(24):11055-64
pubmed: 12486201
Epilepsia. 1997 Nov;38(11 Suppl):S6-8
pubmed: 19909329
Glia. 2019 Dec;67(12):2221-2247
pubmed: 31429127
JCI Insight. 2021 Jan 11;6(1):
pubmed: 33232300
Neurology. 2017 Apr 25;88(17):1674-1680
pubmed: 28438841
Eur J Neurol. 2022 Dec;29(12):3701-3710
pubmed: 36057450
J Physiol. 2012 Jul 15;590(14):3335-47
pubmed: 22615434
Neurology. 2001 Feb 27;56(4):519-25
pubmed: 11222798
J Neurosci. 1999 Jun 15;19(12):5054-65
pubmed: 10366638
Nat Rev Neurol. 2014 May;10(5):271-82
pubmed: 24752120
Clin Exp Pharmacol Physiol. 1998 Oct;25(10):847-56
pubmed: 9784928
Genome Biol. 2006;7(10):R100
pubmed: 17076895
Pflugers Arch. 1996 Apr;431(6):942-9
pubmed: 8927513
J Neurochem. 2007 Feb;100(4):857-73
pubmed: 17212700