Virus-assisted directed evolution of biomolecules.

Viruses / genetics Mutation Directed Molecular Evolution / methods
Continuous evolution Molecular evolution PACE PANCE VADER VEGAS

Journal

Current opinion in chemical biology
ISSN: 1879-0402
Titre abrégé: Curr Opin Chem Biol
Pays: England
ID NLM: 9811312

Informations de publication

Date de publication:
10 2023
Historique:
received: 27 03 2023
revised: 01 07 2023
accepted: 02 07 2023
medline: 22 9 2023
pubmed: 6 8 2023
entrez: 5 8 2023
Statut: ppublish

Résumé

Directed evolution is a powerful technique that uses principles of natural evolution to enable the development of biomolecules with novel functions. However, the slow pace of natural evolution does not support the demand for rapidly generating new biomolecular functions in the laboratory. Viruses offer a unique path to design fast laboratory evolution experiments, owing to their innate ability to evolve much more rapidly than most living organisms, facilitated by a smaller genome size that tolerate a high frequency of mutations, as well as a fast rate of replication. These attributes offer a great opportunity to evolve various biomolecules by linking their activity to the replication of a suitable virus. This review highlights the recent advances in the application of virus-assisted directed evolution of designer biomolecules in both prokaryotic and eukaryotic cells.

Identifiants

DOI: 10.1016/j.cbpa.2023.102375 PMID: 37542745
pubmed: 37542745
pii: S1367-5931(23)00113-8
doi: 10.1016/j.cbpa.2023.102375
pii:
doi:

Types de publication

Journal Article Review Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

102375

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM136437
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Abhishek Chatterjee reports a relationship with BrickBio, Inc. That includes: consulting or advisory and equity or stocks. Abhishek Chatterjee has patent #PCT/US20/38766 pending to BrickBio, Inc. Delilah Jewel has patent #PCT/US20/38766 pending to BrickBio, Inc.

Auteurs

Delilah Jewel (D)

Department of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USA.

Quan Pham (Q)

Department of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USA.

Abhishek Chatterjee (A)

Department of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USA. Electronic address: abhishek.chatterjee@bc.edu.

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Classifications MeSH

questionsmedicales.fr › Virus › Virus-assisted directed evolution of biomolecules.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Virus-assisted directed evolution of biomolecules.
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Évolution moléculaire dirigée › Virus-assisted directed evolution of biomolecules.