Molecular insights into the catalysis and regulation of mammalian NAD-dependent isocitrate dehydrogenases.
Journal
Current opinion in structural biology
ISSN: 1879-033X
Titre abrégé: Curr Opin Struct Biol
Pays: England
ID NLM: 9107784
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
15
03
2023
revised:
08
07
2023
accepted:
10
07
2023
medline:
18
9
2023
pubmed:
6
8
2023
entrez:
5
8
2023
Statut:
ppublish
Résumé
Eukaryotic NAD-dependent isocitrate dehydrogenases (NAD-IDHs) are mitochondria-localized enzymes which catalyze the oxidative decarboxylation of isocitrate to α-ketoglutarate using NAD as a cofactor. In mammals, NAD-IDHs (or IDH3) consist of three types of subunits (α, β, and γ), and exist as (α
Identifiants
pubmed: 37542909
pii: S0959-440X(23)00146-X
doi: 10.1016/j.sbi.2023.102672
pii:
doi:
Substances chimiques
Isocitrate Dehydrogenase
EC 1.1.1.41
NAD
0U46U6E8UK
Isocitrates
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102672Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.