Sex-dependent endozepinergic regulation of ventromedial hypothalamic nucleus glucose counter-regulatory neuron aromatase protein expression in the adult rat.
Animals
Female
Male
Rats
Aromatase
/ metabolism
Estradiol
/ pharmacology
gamma-Aminobutyric Acid
/ metabolism
Glucose
/ metabolism
Glycogen
/ metabolism
Hypoglycemia
/ metabolism
Hypoglycemic Agents
/ pharmacology
Rats, Sprague-Dawley
Transcription Factors
Ventromedial Hypothalamic Nucleus
/ metabolism
Sex Factors
Aromatase
Insulin-induced hypoglycemia
Octadecaneuropeptide
Sex dimorphism
Ventromedial hypothalamic nucleus
Journal
Journal of chemical neuroanatomy
ISSN: 1873-6300
Titre abrégé: J Chem Neuroanat
Pays: Netherlands
ID NLM: 8902615
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
22
06
2023
revised:
01
08
2023
accepted:
02
08
2023
pmc-release:
01
10
2024
medline:
15
9
2023
pubmed:
6
8
2023
entrez:
5
8
2023
Statut:
ppublish
Résumé
The hypothalamic brain cell types that produce estradiol from testosterone remain unclear. Aromatase inhibition affects ventromedial hypothalamic nucleus (VMN) glucose-stimulatory nitric oxide (NO) and glucose-inhibitory γ-aminobutyric acid (GABA) transmission during insulin (INS)-induced hypoglycemia (IIH). Pure GABA and NO nerve cell samples acquired by laser-catapult-microdissection from consecutive rostro-caudal segments of the VMN were analyzed by Western blot to investigate whether regional subpopulations of each cell type contain machinery for neuro-estradiol synthesis. Astrocyte endozepinergic signaling governs brain steroidogenesis. Pharmacological tools were used here to determine if the glio-peptide octadecaneuropeptide (ODN) controls aromatase expression in GABA and NO neurons during eu- and/or hypoglycemia. Intracerebroventricular administration of the ODN G-protein coupled-receptor antagonist cyclo
Identifiants
pubmed: 37543285
pii: S0891-0618(23)00093-5
doi: 10.1016/j.jchemneu.2023.102323
pmc: PMC10528386
mid: NIHMS1924230
pii:
doi:
Substances chimiques
Aromatase
EC 1.14.14.1
Estradiol
4TI98Z838E
gamma-Aminobutyric Acid
56-12-2
Glucose
IY9XDZ35W2
Glycogen
9005-79-2
Hypoglycemic Agents
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
102323Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK109382
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have no conflicts of interests to declare.
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