Clinical findings using echocardiography and plasma cardiac troponin I and pathological findings in dogs with hypertrophic cardiomyopathy: A retrospective study.
Biomarker
Cardiac troponin I
Dog
End-diastolic thickness of the interventricular septum
Hypertrophic cardiomyopathy
Journal
Open veterinary journal
ISSN: 2218-6050
Titre abrégé: Open Vet J
Pays: Libya
ID NLM: 101653182
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
09
03
2023
accepted:
14
05
2023
medline:
8
8
2023
pubmed:
7
8
2023
entrez:
7
8
2023
Statut:
ppublish
Résumé
Hypertrophic cardiomyopathy (HCM) is considered rare in dogs, and there is a lack of clinical data. Cardiac troponin I (cTnI) is a biomarker of cardiomyocyte damage and necrosis and can be used to diagnose cat and human HCM. We investigated whether the presence of cTnI in clinical data can be used in conjunction with echocardiography to diagnose canine HCM. This study comprised client-owned dogs with clinical evidence of concentric hypertrophy on echocardiographic images, serum total thyroxine levels of ≤5 µg/dl, systolic blood pressure of ≤180 mmHg, and absence of aortic stenosis. All cases were necropsied. Cardiomyocyte hypertrophy (mean diameter, 18.3 ± 1.8 µm), myocardial fiber disarray (70%), interstitial fibrosis (80%), and small vessel disease (100%) were assessed. In dogs with HCM, the left ventricles were concentric, almost symmetrical, and hypertrophied above the aortic diameter. The end-diastolic interventricular septum normalized to body weight [intraventricular septal thickness in diastole (IVSDN)] was 0.788 [interquartile range (IQR), 0.7-0.92], which exceeded the normal range (5%-95%, IQR: 0.33-0.52). In total, 70% of the dogs with HCM had syncope and dyspnea, and all dogs had high cTnI levels (median, 3.94 ng/ml), exceeding the upper limit of normal (0.11 ng/ml) and indicating cardiomyocyte damage. IVSDN and serum cTnI levels were correlated ( Ventricular wall thickening and high serum cTnI levels can provide a presumptive diagnosis of HCM and prompt the initiation of treatment or additional diagnostic investigations.
Sections du résumé
Background
Hypertrophic cardiomyopathy (HCM) is considered rare in dogs, and there is a lack of clinical data. Cardiac troponin I (cTnI) is a biomarker of cardiomyocyte damage and necrosis and can be used to diagnose cat and human HCM.
Aim
We investigated whether the presence of cTnI in clinical data can be used in conjunction with echocardiography to diagnose canine HCM.
Methods
This study comprised client-owned dogs with clinical evidence of concentric hypertrophy on echocardiographic images, serum total thyroxine levels of ≤5 µg/dl, systolic blood pressure of ≤180 mmHg, and absence of aortic stenosis. All cases were necropsied.
Results
Cardiomyocyte hypertrophy (mean diameter, 18.3 ± 1.8 µm), myocardial fiber disarray (70%), interstitial fibrosis (80%), and small vessel disease (100%) were assessed. In dogs with HCM, the left ventricles were concentric, almost symmetrical, and hypertrophied above the aortic diameter. The end-diastolic interventricular septum normalized to body weight [intraventricular septal thickness in diastole (IVSDN)] was 0.788 [interquartile range (IQR), 0.7-0.92], which exceeded the normal range (5%-95%, IQR: 0.33-0.52). In total, 70% of the dogs with HCM had syncope and dyspnea, and all dogs had high cTnI levels (median, 3.94 ng/ml), exceeding the upper limit of normal (0.11 ng/ml) and indicating cardiomyocyte damage. IVSDN and serum cTnI levels were correlated (
Conclusion
Ventricular wall thickening and high serum cTnI levels can provide a presumptive diagnosis of HCM and prompt the initiation of treatment or additional diagnostic investigations.
Identifiants
pubmed: 37545712
doi: 10.5455/OVJ.2023.v13.i6.9
pii: OVJ-13-742
pmc: PMC10399649
doi:
Substances chimiques
Troponin I
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
742-752Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest.
Références
J Vet Intern Med. 2004 May-Jun;18(3):311-21
pubmed: 15188817
J Am Coll Cardiol. 2010 Sep 28;56(14):1071-8
pubmed: 20863950
J Vet Cardiol. 2003 Nov;5(2):39-45
pubmed: 19081364
J Vet Intern Med. 2019 May;33(3):1242-1250
pubmed: 30990935
Int Heart J. 2019 May 30;60(3):648-655
pubmed: 31019180
Acta Paediatr Suppl. 2002;91(439):10-4
pubmed: 12572836
Ann Glob Health. 2014 Jan-Feb;80(1):35-45
pubmed: 24751563
Am J Cardiol. 2008 Oct 15;102(8):1107-10
pubmed: 18946930
Circ J. 2011;75(4):919-26
pubmed: 21304210
BMC Cardiovasc Disord. 2013 Sep 11;13:70
pubmed: 24020864
J Am Vet Med Assoc. 1995 Jan 15;206(2):194-9
pubmed: 7751220
Cardiol Res. 2017 Aug;8(4):139-142
pubmed: 28868097
J Vet Intern Med. 2009 Nov-Dec;23(6):1142-50
pubmed: 19780929
J Vet Cardiol. 2015 Dec;17 Suppl 1:S6-9
pubmed: 26776595
J Vet Intern Med. 2000 Jul-Aug;14(4):429-35
pubmed: 10935894
Circulation. 1996 Mar 1;93(5):841-2
pubmed: 8598070
Clin Biochem. 1996 Dec;29(6):587-94
pubmed: 8939408
J Vet Intern Med. 2001 Sep-Oct;15(5):501-3
pubmed: 11596740
J Vet Med Sci. 2003 Jun;65(6):753-6
pubmed: 12867741
Clin Chem. 1994 Jul;40(7 Pt 1):1291-5
pubmed: 8013101
Clin Cardiol. 2010 Feb;33(2):E1-7
pubmed: 20043329
Am J Pathol. 1979 Mar;94(3):497-508
pubmed: 154845
Am J Vet Res. 2002 Jul;63(7):994-9
pubmed: 12118681
Clin Chim Acta. 2004 Jul;345(1-2):123-7
pubmed: 15193986
Ital J Pediatr. 2012 Sep 04;38:39
pubmed: 22947590
Arch Cardiol Mex. 2006 Oct-Dec;76(4):415-8
pubmed: 17315619
J Vet Intern Med. 2004 Nov-Dec;18(6):831-9
pubmed: 15638266
J Vet Intern Med. 2022 May;36(3):865-876
pubmed: 35322461
Jpn Circ J. 1982 Mar;46(3):225-34
pubmed: 7199592
J Vet Intern Med. 2016 Jan-Feb;30(1):36-50
pubmed: 26681537
J Vet Intern Med. 2018 May;32(3):930-943
pubmed: 29660848
J Vet Intern Med. 2014 Sep-Oct;28(5):1485-91
pubmed: 25056593
Eur Heart J. 2009 Jan;30(2):139-51
pubmed: 19136482
Circulation. 1981 Feb;63(2):409-18
pubmed: 6450004
Circulation. 1983 May;67(5):1109-16
pubmed: 6682019
J Vet Cardiol. 2017 Oct;19(5):405-415
pubmed: 28965673
J Vet Intern Med. 1992 Jul-Aug;6(4):220-4
pubmed: 1522552
J Am Vet Med Assoc. 1993 Oct 1;203(7):1020-2
pubmed: 8226248
Open Vet J. 2021 Jul-Sep;11(3):468-470
pubmed: 34722212
J Am Coll Cardiol. 2011 Jun 14;57(24):2406-8
pubmed: 21658560
J Am Vet Med Assoc. 1979 Apr 1;174(7):708-13
pubmed: 429233
Circulation. 2011 Dec 13;124(24):e783-831
pubmed: 22068434
J Vet Intern Med. 2020 May;34(3):1062-1077
pubmed: 32243654
J Vet Intern Med. 2007 Jan-Feb;21(1):61-7
pubmed: 17338151
Can Vet J. 2005 Dec;46(12):1122-5
pubmed: 16422064
Clin Chim Acta. 2010 Mar;411(5-6):318-23
pubmed: 20036224
Yale J Biol Med. 2017 Sep 25;90(3):433-448
pubmed: 28955182
Vet Clin North Am Small Anim Pract. 2000 Mar;30(2):379-93, vii
pubmed: 10768239
Echocardiography. 2021 Oct;38(10):1795-1808
pubmed: 34555207
J Vet Intern Med. 2018 May;32(3):922-929
pubmed: 29660794
Can Vet J. 2016 Jun;57(6):641-5
pubmed: 27247465
Vet World. 2019 Jun;12(6):740-747
pubmed: 31439987
J Vet Intern Med. 2013 Nov-Dec;27(6):1427-36
pubmed: 24134821
J Vet Cardiol. 2019 Aug;24:36-47
pubmed: 31405553
Vet J. 2010 Jun;184(3):334-9
pubmed: 19703781
J Small Anim Pract. 2014 Apr;55(4):198-206
pubmed: 24506774