Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
29 Jul 2023
29 Jul 2023
Historique:
pubmed:
7
8
2023
medline:
7
8
2023
entrez:
7
8
2023
Statut:
epublish
Résumé
Homology Directed Repair (HDR)-based genome editing is an approach that could permanently correct a broad range of genetic diseases. However, its utility is limited by inefficient and imprecise DNA repair mechanisms in terminally differentiated tissues. Here, we tested "Repair Drive", a novel method for improving targeted gene insertion in the liver by selectively expanding correctly repaired hepatocytes
Identifiants
pubmed: 37546995
doi: 10.1101/2023.07.26.550728
pmc: PMC10402145
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : UG3 HL151545
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL152314
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK115461
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132840
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA125123
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK056338
Pays : United States
Organisme : NIH HHS
ID : U42 OD026645
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124477
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK115461
Pays : United States
Déclaration de conflit d'intérêts
Competing Interests. W.R.L., A.H., K.D.B., M.D.G., and M.N.F. have filed a patent application for the Repair Drive technology and its application to gene therapy.