Adam Castoreno

Affiliations

Alnylam Pharmaceuticals, Cambridge, MA, USA.

Publications (9)

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.

Nature biotechnology

Avec: Kirk M Brown , Jayaprakash K Nair , Maja M Janas , Yesseinia I Anglero-Rodriguez , Lan T H Dang , Haiyan Peng , Christopher S Theile , Elena Castellanos-Rizaldos , Christopher Brown , Donald Foster , Jeffrey Kurz , Jeffrey Allen , Rajanikanth Maganti , Jing Li , Shigeo Matsuda , Matthew Stricos , Tyler Chickering , Michelle Jung , Kelly Wassarman , Jeff Rollins , Lauren Woods , Alex Kelin , Dale C Guenther , Melissa W Mobley , John Petrulis , Robin McDougall , Timothy Racie , Jessica Bombardier , Diana Cha , Saket Agarwal , Lei Johnson , Yongfeng Jiang , Scott Lentini , Jason Gilbert , Tuyen Nguyen , Samantha Chigas , Sarah LeBlanc , Urjana Poreci , Anne Kasper , Arlin B Rogers , Saeho Chong , Wendell Davis , Jessica E Sutherland , Adam Castoreno , Stuart Milstein , Mark K Schlegel , Ivan Zlatev , Klaus Charisse , Mark Keating , Muthiah Manoharan , Kevin Fitzgerald , Jing-Tao Wu , Martin A Maier , Vasant Jadhav

Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5'-exonuclease.

Nucleic acids research

Avec: Pawan Kumar , Rohan Degaonkar , Dale C Guenther , Mikhail Abramov , Guy Schepers , Marie Capobianco , Yongfeng Jiang , Joel Harp , Charalambos Kaittanis , Maja M Janas , Adam Castoreno , Ivan Zlatev , Mark K Schlegel , Piet Herdewijn , Martin Egli , Muthiah Manoharan

From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.

Nucleic acids research

Avec: Mark K Schlegel , Maja M Janas , Yongfeng Jiang , Joseph D Barry , Wendell Davis , Saket Agarwal , Daniel Berman , Christopher R Brown , Adam Castoreno , Sarah LeBlanc , Abigail Liebow , Tara Mayo , Stuart Milstein , Tuyen Nguyen , Svetlana Shulga-Morskaya , Sarah Hyde , Sally Schofield , John Szeto , Lauren Blair Woods , Vedat O Yilmaz , Muthiah Manoharan , Martin Egli , Klaus Charissé , Laura Sepp-Lorenzino , Patrick Haslett , Kevin Fitzgerald , Vasant Jadhav , Martin A Maier

An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema.

RNA (New York, N.Y.)

Avec: Jingxuan Liu , June Qin , Anna Borodovsky , Timothy Racie , Adam Castoreno , Mark Schlegel , Martin A Maier , Tracy Zimmerman , Kevin Fitzgerald , James Butler , Akin Akinc

Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing.

Nucleic acids research

Avec: Hartmut Jahns , Rohan Degaonkar , Peter Podbevsek , Swati Gupta , Anna Bisbe , Krishna Aluri , John Szeto , Pawan Kumar , Sarah LeBlanc , Tim Racie , Christopher R Brown , Adam Castoreno , Dale C Guenther , Vasant Jadhav , Martin A Maier , Janez Plavec , Martin Egli , Muthiah Manoharan , Ivan Zlatev

Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates.

Nucleic acids research

Avec: Mikyung Yu , June Qin , Xiumin Liu , Diane Ramsden , Brian Williams , Ivan Zlatev , Dale Guenther , Shigeo Matsuda , Roxanne Tymon , Justin Darcy , Catrina Wong , Jamie Tsung , Peter Zawaneh , Saeho Chong , Christopher S Theile , Nathan Taneja , Arlin Rogers , Ju Liu , Elena Castellanos-Rizaldos , Sarah Bond , Kawai So , Jason Denoncourt , Adam Castoreno , Muthiah Manoharan , Jing-Tao Wu , Kevin Fitzgerald , Martin A Maier , Vasant Jadhav , Jayaprakash K Nair

Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.

Nucleic acids research

Avec: Mark K Schlegel , Shigeo Matsuda , Christopher R Brown , Joel M Harp , Joseph D Barry , Daniel Berman , Adam Castoreno , Sally Schofield , John Szeto , Muthiah Manoharan , Klaus Charissé , Martin Egli , Martin A Maier

bioRxiv : the preprint server for biology

Avec: Marco De Giorgi , So Hyun Park , Adam Castoreno , Mingming Cao , Ayrea Hurley , Lavanya Saxena , Marcel A Chuecos , Christopher J Walkey , Alexandria M Doerfler , Mia N Furgurson , M Cecilia Ljungberg , Kalyani R Patel , Sarah Hyde , Tyler Chickering , Stephanie Lefebvre , Kelly Wassarman , Patrick Miller , June Qin , Mark K Schlegel , Ivan Zlatev , Rich Gang Li , Jong Kim , James F Martin , Karl-Dimiter Bissig , Vasant Jadhav , Gang Bao , William R Lagor

Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.

Journal of the American Chemical Society

Avec: Shigeo Matsuda , Saikat Bala , Jen-Yu Liao , Dhrubajyoti Datta , Atsushi Mikami , Lauren Woods , Joel M Harp , Jason A Gilbert , Anna Bisbe , Rajar M Manoharan , MaryBeth Kim , Christopher S Theile , Dale C Guenther , Yongfeng Jiang , Saket Agarwal , Rajanikanth Maganti , Mark K Schlegel , Ivan Zlatev , Klaus Charisse , Kallanthottathil G Rajeev , Adam Castoreno , Martin Maier , Maja M Janas , Martin Egli , John C Chaput , Muthiah Manoharan

Réseau de co-auteurs

Muthiah Manoharan 7 collaborations

Mark K Schlegel 6 collaborations

Ivan Zlatev 6 collaborations

Martin A Maier 6 collaborations

Vasant Jadhav 5 collaborations

Martin Egli 5 collaborations

Maja M Janas 4 collaborations

Shigeo Matsuda 4 collaborations

Dale C Guenther 4 collaborations

Yongfeng Jiang 4 collaborations

Kevin Fitzgerald 4 collaborations

Christopher S Theile 3 collaborations

Saket Agarwal 3 collaborations

Sarah LeBlanc 3 collaborations

Christopher R Brown 3 collaborations

John Szeto 3 collaborations

June Qin 3 collaborations

Jayaprakash K Nair 2 collaborations

Elena Castellanos-Rizaldos 2 collaborations

Rajanikanth Maganti 2 collaborations

Tyler Chickering 2 collaborations

Kelly Wassarman 2 collaborations

Lauren Woods 2 collaborations

Timothy Racie 2 collaborations

Tuyen Nguyen 2 collaborations

Saeho Chong 2 collaborations

Wendell Davis 2 collaborations

Stuart Milstein 2 collaborations

Klaus Charisse 2 collaborations

Jing-Tao Wu 2 collaborations

Pawan Kumar 2 collaborations

Rohan Degaonkar 2 collaborations

Joseph D Barry 2 collaborations

Daniel Berman 2 collaborations

Sarah Hyde 2 collaborations

Sally Schofield 2 collaborations

Klaus Charissé 2 collaborations

Anna Bisbe 2 collaborations

Joel M Harp 2 collaborations

Kirk M Brown 1 collaboration

Yesseinia I Anglero-Rodriguez 1 collaboration

Lan T H Dang 1 collaboration

Haiyan Peng 1 collaboration

Christopher Brown 1 collaboration

Donald Foster 1 collaboration

Jeffrey Kurz 1 collaboration

Jeffrey Allen 1 collaboration

Jing Li 1 collaboration

Matthew Stricos 1 collaboration

Michelle Jung 1 collaboration

Jeff Rollins 1 collaboration

Alex Kelin 1 collaboration

Melissa W Mobley 1 collaboration

John Petrulis 1 collaboration

Robin McDougall 1 collaboration

Jessica Bombardier 1 collaboration

Diana Cha 1 collaboration

Lei Johnson 1 collaboration

Scott Lentini 1 collaboration

Jason Gilbert 1 collaboration

Samantha Chigas 1 collaboration

Urjana Poreci 1 collaboration

Anne Kasper 1 collaboration

Arlin B Rogers 1 collaboration

Jessica E Sutherland 1 collaboration

Mark Keating 1 collaboration

Mikhail Abramov 1 collaboration

Guy Schepers 1 collaboration

Marie Capobianco 1 collaboration

Joel Harp 1 collaboration

Charalambos Kaittanis 1 collaboration

Piet Herdewijn 1 collaboration

Abigail Liebow 1 collaboration

Tara Mayo 1 collaboration

Svetlana Shulga-Morskaya 1 collaboration

Lauren Blair Woods 1 collaboration

Vedat O Yilmaz 1 collaboration

Laura Sepp-Lorenzino 1 collaboration

Patrick Haslett 1 collaboration

Jingxuan Liu 1 collaboration

Anna Borodovsky 1 collaboration

Mark Schlegel 1 collaboration

Tracy Zimmerman 1 collaboration

James Butler 1 collaboration

Akin Akinc 1 collaboration

Hartmut Jahns 1 collaboration

Peter Podbevsek 1 collaboration

Swati Gupta 1 collaboration

Krishna Aluri 1 collaboration

Tim Racie 1 collaboration

Janez Plavec 1 collaboration

Mikyung Yu 1 collaboration

Xiumin Liu 1 collaboration

Diane Ramsden 1 collaboration

Brian Williams 1 collaboration

Dale Guenther 1 collaboration

Roxanne Tymon 1 collaboration

Justin Darcy 1 collaboration

Catrina Wong 1 collaboration

Jamie Tsung 1 collaboration

Peter Zawaneh 1 collaboration

Nathan Taneja 1 collaboration

Arlin Rogers 1 collaboration

Ju Liu 1 collaboration

Sarah Bond 1 collaboration

Kawai So 1 collaboration

Jason Denoncourt 1 collaboration

Marco De Giorgi 1 collaboration

So Hyun Park 1 collaboration

Mingming Cao 1 collaboration

Ayrea Hurley 1 collaboration

Lavanya Saxena 1 collaboration

Marcel A Chuecos 1 collaboration

Christopher J Walkey 1 collaboration

Alexandria M Doerfler 1 collaboration

Mia N Furgurson 1 collaboration

M Cecilia Ljungberg 1 collaboration

Kalyani R Patel 1 collaboration

Stephanie Lefebvre 1 collaboration

Patrick Miller 1 collaboration

Rich Gang Li 1 collaboration

Jong Kim 1 collaboration

James F Martin 1 collaboration

Karl-Dimiter Bissig 1 collaboration

Gang Bao 1 collaboration

William R Lagor 1 collaboration

Saikat Bala 1 collaboration

Jen-Yu Liao 1 collaboration

Dhrubajyoti Datta 1 collaboration

Atsushi Mikami 1 collaboration

Jason A Gilbert 1 collaboration

Rajar M Manoharan 1 collaboration

MaryBeth Kim 1 collaboration

Kallanthottathil G Rajeev 1 collaboration

Martin Maier 1 collaboration

John C Chaput 1 collaboration