Patient and Caregiver Perceptions of Airway Clearance Methods Used for Cystic Fibrosis.

Cystic Fibrosis Foundation guidelines recommend people with CF perform daily airway clearance. This can be difficult for patients, as some find it time consuming or uncomfortable. Data comparing airway clearance methods are limited. We surveyed patients and their families to understand which methods are preferred and identify obstacles to performing airway clearance. We designed a REDCap survey and enrolled participants in 2021. Respondents reported information on airway clearance usage, time commitment, and medication use. They rated airway clearance methods for effectiveness, comfort, time commitment, importance, and compatibility with other treatments. The analysis included descriptive statistics and clustering. 60 respondents started and 52 completed the survey. The median patient age was 20 years. Respondents experienced a median of four airway clearance methods in their lifetime, including chest wall oscillation (vest, 92%), manual chest physical therapy (CPT, 88%), forced expiration technique (huff or cough, 77%), and exercise (75%). Past 30-day use was highest for exercise (62%) and vest (57%). The time commitment was generally less than 2 hours daily. Of those eligible for CFTR modulators, 53% reported decreased time commitment to airway clearance after starting treatment. On a scale of 0-100, respondents rated CFTR modulators as their most important treatment (median 99.5), followed by exercise (88).

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Copyright © 2023 Zoe E. Kienenberger et al.

Déclaration de conflit d'intérêts

Dr. Singh is now an employee of Johnson & Johnson. Dr. Singh's spouse is now an employee of Vertex Pharmaceuticals. Dr. Larson Ode has received an honorarium from Vertex Pharmaceuticals for participating in an advisory panel. Dr. Fischer and Dr. Larson Ode have received grant funding from the Cystic Fibrosis Foundation.