Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.

Anti-Bacterial Agents / pharmacology Escherichia coli / genetics beta-Lactamases / genetics Proteomics Drug Resistance, Bacterial Drug Resistance, Multiple, Bacterial / genetics Klebsiella pneumoniae Microbial Sensitivity Tests
Gram-negative pathogens antimicrobial resistance antimicrobials genomics proteomics

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
15 08 2023
Historique:
medline: 9 8 2023
pubmed: 7 8 2023
entrez: 7 8 2023
Statut: ppublish

Résumé

Microbes evolve rapidly by modifying their genomes through mutations or through the horizontal acquisition of mobile genetic elements (MGEs) linked with fitness traits such as antimicrobial resistance (AMR), virulence, and metabolic functions. We conducted a multicentric study in India and collected different clinical samples for decoding the genome sequences of bacterial pathogens associated with sepsis, urinary tract infections, and respiratory infections to understand the functional potency associated with AMR and its dynamics. Genomic analysis identified several acquired AMR genes (ARGs) that have a pathogen-specific signature. We observed that

Identifiants

DOI: 10.1073/pnas.2305465120 PMID: 37549252 PMC: PMC10434301
pubmed: 37549252
doi: 10.1073/pnas.2305465120
pmc: PMC10434301
doi:

Substances chimiques

Anti-Bacterial Agents 0
beta-Lactamases EC 3.5.2.6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2305465120

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Auteurs

Tanshi Mehrotra (T)

Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.

Dipasri Konar (D)

Division of Diagnostic Laboratory, Jan Swasthya Sahyog, Ganiyari, Bilaspur 495112, India.

Agila Kumari Pragasam (AK)

Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.

Shakti Kumar (S)

Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.

Pradipta Jana (P)

Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.

Prabhakar Babele (P)

Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.

Deepjyoti Paul (D)

Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.

Ayushi Purohit (A)

Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.

Subhash Tanwar (S)

Multidisciplinary Clinical and Translational Research, Translational Health Science and Technology Institute, Faridabad 121001, India.

Susmita Bakshi (S)

Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.

Santanu Das (S)

Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.

Jyoti Verma (J)

Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.

Daizee Talukdar (D)

Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.

Lekshmi Narendrakumar (L)

Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.

Akanksha Kothidar (A)

Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.

Sonali Porey Karmakar (SP)

Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.

Susmita Chaudhuri (S)

Multidisciplinary Clinical and Translational Research, Translational Health Science and Technology Institute, Faridabad 121001, India.

Sujoy Pal (S)

Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India.

Kajal Jain (K)

Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India.

Chittur V Srikanth (CV)

Laboratory of Gut Infection and Inflammation Biology, Regional Centre for Biotechnology, Faridabad 121001, India.

M Jeeva Sankar (MJ)

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India.

Krishnamohan Atmakuri (K)

Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.

Ramesh Agarwal (R)

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India.

Rajni Gaind (R)

Department of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi 110029, India.

Mamatha Ballal (M)

Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal 576104, India.

Nagamani Kammili (N)

Department of Microbiology, Pathogen Biology Division, Gandhi Medical College and Hospital, Secunderabad 500003, India.

Rupak K Bhadra (RK)

Infectious Diseases and Immunology Division, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata 700 032, India.

Thandavarayan Ramamurthy (T)

Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Division of Bacteriology, Indian Council of Medical Research-National Institute of Cholera and Enteric Diseases, Kolkata 700010, India.

G Balakrish Nair (GB)

Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
Pathogen Biology Division, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram 695014, India.

Bhabatosh Das (B)

Infection and Immunology Division, Functional Genomics Laboratory, Centre for Microbial Research, Translational Health Science and Technology Institute, Faridabad 121001, India.
ORCID: 0000-0002-2447-5380

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antimicrobial resistance heterogeneity among...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Antimicrobial resistance heterogeneity among...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › bêta-Lactamases › Antimicrobial resistance heterogeneity among...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Antimicrobial resistance heterogeneity among...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Antimicrobial resistance heterogeneity among...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Multirésistance aux médicaments › Multirésistance bactérienne aux médicaments › Antimicrobial resistance heterogeneity among...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Klebsiella › Klebsiella pneumoniae › Antimicrobial resistance heterogeneity among...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Antimicrobial resistance heterogeneity among...