The road less traveled: activating an oncogenic kinase.

Humans Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Reperfusion Injury Protein Isoforms
PI3K kinase oncogene targeted therapy

Journal

Trends in pharmacological sciences
ISSN: 1873-3735
Titre abrégé: Trends Pharmacol Sci
Pays: England
ID NLM: 7906158

Informations de publication

Date de publication:
10 2023
Historique:
received: 28 06 2023
revised: 24 07 2023
accepted: 24 07 2023
medline: 18 9 2023
pubmed: 9 8 2023
entrez: 8 8 2023
Statut: ppublish

Résumé

Elevated phosphoinositide 3-kinase (PI3K) activity in human tumors has prompted widespread efforts to develop chemical PI3K inhibitors for oncology indications. In an innovative new study, Gong et al. report the discovery of a highly selective activator of the PI3Kα isoform, with promising activity in assays of nerve regrowth and cardioprotection from ischemia-reperfusion injury (IRI).

Identifiants

DOI: 10.1016/j.tips.2023.07.005 PMID: 37553270
pubmed: 37553270
pii: S0165-6147(23)00167-0
doi: 10.1016/j.tips.2023.07.005
pii:
doi:

Substances chimiques

Phosphatidylinositol 3-Kinases EC 2.7.1.-
Phosphoinositide-3 Kinase Inhibitors 0
Protein Isoforms 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

640-642

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests None declared by authors.

Auteurs

Madhuri Paul (M)

Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA.

David A Fruman (DA)

Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA. Electronic address: dfruman@uci.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The road less traveled: activating an oncogenic kinase.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › The road less traveled: activating an oncogenic kinase.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs des phosphoinositide-3 kinases › The road less traveled: activating an oncogenic kinase.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Lésion d'ischémie-reperfusion › The road less traveled: activating an oncogenic kinase.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › The road less traveled: activating an oncogenic kinase.