Resident dendritic cell density in the lymph node paracortex is preDC-estined.

Lymphoid Tissue Lymph Nodes Dendritic Cells

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
08 08 2023
Historique:
received: 16 07 2023
revised: 17 07 2023
accepted: 18 07 2023
medline: 11 8 2023
pubmed: 10 8 2023
entrez: 9 8 2023
Statut: ppublish

Résumé

Dendritic cells (DCs) are relatively short lived, yet DC frequencies in lymph nodes are stable. In this issue of Immunity, Ugur et al. reveal that type 1 conventional DCs (cDC1s) are maintained in the deep paracortex of the lymph node from a supply of preDCs that proliferate in nearby medullary vessels. Transition from preDC to cDC1 is regulated by Flt3L sensing.

Identifiants

DOI: 10.1016/j.immuni.2023.07.013 PMID: 37557075
pubmed: 37557075
pii: S1074-7613(23)00326-6
doi: 10.1016/j.immuni.2023.07.013
pii:
doi:

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

1699-1701

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Rafael S Czepielewski (RS)

Immunology Center of Georgia, Medical College of Georgia, Department of Physiology, Augusta University, Augusta, GA, USA.

Gwendalyn J Randolph (GJ)

Department of Pathology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: gjrandolph@wustl.edu.

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Resident dendritic cell density in the lymph...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Noeuds lymphatiques › Resident dendritic cell density in the lymph...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › Resident dendritic cell density in the lymph...