Genetic Risk Stratification in Arrhythmogenic Left Ventricular Cardiomyopathy.
Arrhythmia
Cardiomyopathy
Genetics
Precision medicine
Risk prediction
Sudden cardiac death
Journal
Cardiac electrophysiology clinics
ISSN: 1877-9190
Titre abrégé: Card Electrophysiol Clin
Pays: United States
ID NLM: 101549998
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
medline:
11
8
2023
pubmed:
10
8
2023
entrez:
9
8
2023
Statut:
ppublish
Résumé
Arrhythmogenic left ventricular cardiomyopathy is characterized by early malignant ventricular arrhythmia associated with varying degrees and times of onset of left ventricular dysfunction. Variants in numerous genes have been associated with this phenotype. Here, the authors review the literature on recent cohort studies of patients with variants in desmoplakin, lamin A/C, filamin-C, phospholamban, RBM20, TMEM43, and selected channelopathy genes also associated with structural disease. Unlike traditional sudden cardiac death risk assessment in nonischemic cardiomyopathy, left ventricular systolic function is an insensitive predictor of risk in patients with these genetic diagnoses.
Identifiants
pubmed: 37558308
pii: S1877-9182(23)00042-4
doi: 10.1016/j.ccep.2023.04.005
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
391-399Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.