Vidarabine, an anti-herpes agent, improves Porphyromonas gingivalis lipopolysaccharide-induced cardiac dysfunction in mice.
Adenylyl cyclase
Apoptosis
Fibrosis
Heart failure
Periodontitis
Signal transduction
β-Adrenergic signaling
Journal
The journal of physiological sciences : JPS
ISSN: 1880-6562
Titre abrégé: J Physiol Sci
Pays: Japan
ID NLM: 101262417
Informations de publication
Date de publication:
09 Aug 2023
09 Aug 2023
Historique:
received:
13
04
2023
accepted:
02
07
2023
medline:
11
8
2023
pubmed:
10
8
2023
entrez:
9
8
2023
Statut:
epublish
Résumé
In this work, we examined the involvement of type 5 adenylyl cyclase (AC5) in cardiac dysfunction induced in mice given Porphyromonas gingivalis lipopolysaccharide (PG-LPS) at a dose equivalent to the circulating levels in periodontitis (PD) patients. Cardiac function was significantly decreased in mice given PG-LPS compared to the control, but treatment for 1 week with the AC5 inhibitor vidarabine ameliorated the dysfunction. Cardiac fibrosis and myocyte apoptosis were significantly increased in the PG-LPS group, but vidarabine blocked these changes. The PG-LPS-induced cardiac dysfunction was associated with activation of cyclic AMP/Ca
Identifiants
pubmed: 37558983
doi: 10.1186/s12576-023-00873-5
pii: 10.1186/s12576-023-00873-5
pmc: PMC10717078
doi:
Substances chimiques
Vidarabine
FA2DM6879K
Lipopolysaccharides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
18Subventions
Organisme : Japan Society for the Promotion of Science
ID : 22K21003
Organisme : Japan Society for the Promotion of Science
ID : 20K10304
Organisme : Japan Society for the Promotion of Science
ID : 20K10305
Organisme : Japan Society for the Promotion of Science
ID : 19K24109
Organisme : Japan Society for the Promotion of Science
ID : 21K17171
Organisme : Japan Society for the Promotion of Science
ID : 22K10255
Organisme : Japan Society for the Promotion of Science
ID : 21K10242
Informations de copyright
© 2023. The Physiological Society of Japan.
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