ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways.
Humans
Cytomegalovirus
/ physiology
Tumor Necrosis Factor-alpha
/ metabolism
Proteome
/ metabolism
Receptors, Tumor Necrosis Factor, Type II
/ metabolism
Proteomics
Membrane Proteins
/ genetics
Cytokines
/ metabolism
Cell Membrane
/ metabolism
Metalloproteases
/ metabolism
ADAM17 Protein
/ genetics
Membrane Glycoproteins
/ metabolism
Viral Proteins
/ metabolism
ADAM17
Human cytomegalovirus
Immune regulation
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
15 08 2023
15 08 2023
Historique:
medline:
14
8
2023
pubmed:
10
8
2023
entrez:
10
8
2023
Statut:
ppublish
Résumé
Human cytomegalovirus (HCMV) is a major human pathogen whose life-long persistence is enabled by its remarkable capacity to systematically subvert host immune defenses. In exploring the finding that HCMV infection up-regulates tumor necrosis factor receptor 2 (TNFR2), a ligand for the pro-inflammatory antiviral cytokine TNFα, we found that the underlying mechanism was due to targeting of the protease, A Disintegrin And Metalloproteinase 17 (ADAM17). ADAM17 is the prototype 'sheddase', a family of proteases that cleaves other membrane-bound proteins to release biologically active ectodomains into the supernatant. HCMV impaired ADAM17 surface expression through the action of two virally-encoded proteins in its U
Identifiants
pubmed: 37561786
doi: 10.1073/pnas.2303155120
pmc: PMC10438378
doi:
Substances chimiques
Tumor Necrosis Factor-alpha
0
Proteome
0
Receptors, Tumor Necrosis Factor, Type II
0
Membrane Proteins
0
Cytokines
0
Metalloproteases
EC 3.4.-
ADAM17 Protein
EC 3.4.24.86
UL144 ORF protein, Human herpesvirus 5
0
Membrane Glycoproteins
0
Viral Proteins
0
ADAM17 protein, human
EC 3.4.24.86
UL148 protein, human cytomegalovirus
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2303155120Subventions
Organisme : Medical Research Council
ID : MR/P001602/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V000489/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S00971X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12014/3
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 100326/Z/12/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 108070/Z/15/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 207503/Z/17/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V000489/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204870
Pays : United Kingdom
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