Basigin is released in extracellular vesicles derived from the renal tubular epithelium in response to albuminuria.
Basigin
albuminuria
extracellular vesicles
renal tubular injury
Journal
Nephrology (Carlton, Vic.)
ISSN: 1440-1797
Titre abrégé: Nephrology (Carlton)
Pays: Australia
ID NLM: 9615568
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
24
07
2023
received:
06
01
2023
accepted:
26
07
2023
medline:
3
10
2023
pubmed:
11
8
2023
entrez:
10
8
2023
Statut:
ppublish
Résumé
Irrespective of the cause, albumin/proteinuria induces tubulointerstitial damage and accelerates the progression of kidney diseases. Our series of studies demonstrated that proteinuria, an independent prognostic factor for chronic kidney disease (CKD), is correlated with urinary basigin/CD147 (Bsg) levels. We examined the morphology and origin of Bsg in the tubular lumen through the effects of filtered glucose and protein solutes on the tubules. Diabetic kidney disease (DKD) patients (N = 50) were treated with spironolactone 25 mg for 4 weeks or by conservative treatment. The associations between urinary Bsg values and clinical indicators were examined. Primary-cultured proximal tubular epithelial cells (PTECs) from human adult kidneys were exposed to high glucose or bovine serum albumin (BSA). In patients with early phase DKD, urinary Bsg levels were closely correlated with proteinuria but not HbA1c. Full-length Bsg on extracellular vesicles (EVs) was investigated primarily in urine collected from DKD patients. EVs obtained from the urine of DKD patients included Bsg and SGLT2 proteins. Notably, spironolactone treatment concomitantly suppressed the release of Bsg-bearing EVs in correlation with decreased albuminuria. Exposure of PTECs to BSA (but not high glucose) enhanced the storage of supernatant Bsg in EVs despite the absence of exposure-specific changes in Bsg transcription. Proteinuria induces the release of Bsg-bearing EVs derived from PTECs into the tubular lumen.
Substances chimiques
Basigin
136894-56-9
Spironolactone
27O7W4T232
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
629-638Subventions
Organisme : Grant-in-Aid for Progressive Renal Diseases Research, Research on Rare and Intractable Diseases, Nephrology Research, from the Ministry of Health, Labour and Welfare of Japan
ID : 90584681
Informations de copyright
© 2023 Asian Pacific Society of Nephrology.
Références
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