An oscillatory mechanism for multi-level storage in short-term memory.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
10 08 2023
10 08 2023
Historique:
received:
01
04
2022
accepted:
01
08
2023
medline:
14
8
2023
pubmed:
11
8
2023
entrez:
10
8
2023
Statut:
epublish
Résumé
Oscillatory activity is commonly observed during the maintenance of information in short-term memory, but its role remains unclear. Non-oscillatory models of short-term memory storage are able to encode stimulus identity through their spatial patterns of activity, but are typically limited to either an all-or-none representation of stimulus amplitude or exhibit a biologically implausible exact-tuning condition. Here we demonstrate a simple mechanism by which oscillatory input enables a circuit to generate persistent or sequential activity that encodes information not only in the spatial pattern of activity, but also in the amplitude of activity. This is accomplished through a phase-locking phenomenon that permits many different amplitudes of persistent activity to be stored without requiring exact tuning of model parameters. Altogether, this work proposes a class of models for the storage of information in working memory, a potential role for brain oscillations, and a dynamical mechanism for maintaining multi-stable neural representations.
Identifiants
pubmed: 37563448
doi: 10.1038/s42003-023-05200-7
pii: 10.1038/s42003-023-05200-7
pmc: PMC10415352
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
829Subventions
Organisme : NEI NIH HHS
ID : R01 EY027036
Pays : United States
Organisme : NINDS NIH HHS
ID : U19 NS104648
Pays : United States
Informations de copyright
© 2023. Springer Nature Limited.
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