Geometric Mismatch Promotes Anatomic Repair in Periorbital Bony Defects in Skeletally Mature Yucatan Minipigs.

Swine Animals Tissue Scaffolds Swine, Miniature Printing, Three-Dimensional Biocompatible Materials / pharmacology Bone Regeneration Osteogenesis
3D-printing Yucatan pigs bone regeneration geometric mismatch image registration midfacial scaffolds

Journal

Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613

Informations de publication

Date de publication:
11 2023
Historique:
revised: 04 08 2023
received: 03 07 2023
medline: 23 11 2023
pubmed: 11 8 2023
entrez: 11 8 2023
Statut: ppublish

Résumé

Porous tissue-engineered 3D-printed scaffolds are a compelling alternative to autografts for the treatment of large periorbital bone defects. Matching the defect-specific geometry has long been considered an optimal strategy to restore pre-injury anatomy. However, studies in large animal models have revealed that biomaterial-induced bone formation largely occurs around the scaffold periphery. Such ectopic bone formation in the periorbital region can affect vision and cause disfigurement. To enhance anatomic reconstruction, geometric mismatches are introduced in the scaffolds used to treat full thickness zygomatic defects created bilaterally in adult Yucatan minipigs. 3D-printed, anatomically-mirrored scaffolds are used in combination with autologous stromal vascular fraction of cells (SVF) for treatment. An advanced image-registration workflow is developed to quantify the post-surgical geometric mismatch and correlate it with the spatial pattern of the regenerating bone. Osteoconductive bone growth on the dorsal and ventral aspect of the defect enhances scaffold integration with the native bone while medio-lateral bone growth leads to failure of the scaffolds to integrate. A strong positive correlation is found between geometric mismatch and orthotopic bone deposition at the defect site. The data suggest that strategic mismatch >20% could improve bone scaffold design to promote enhanced regeneration, osseointegration, and long-term scaffold survivability.

Identifiants

DOI: 10.1002/adhm.202301944 PMID: 37565378
pubmed: 37565378
doi: 10.1002/adhm.202301944
doi:

Substances chimiques

Biocompatible Materials 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2301944

Subventions

Organisme : NIDCR NIH HHS
ID : R01 DE027957
Pays : United States
Organisme : NIH HHS
ID : R01DE027957
Pays : United States
Organisme : NIH HHS
ID : R01DE027957
Pays : United States

Informations de copyright

© 2023 Wiley-VCH GmbH.

Références

P. Su, C. Paquet, K. O'Dell, D. Reinstadler, N. Kokot, J. Granzow, T. N. Chambers, A. Kochhar, Laryngoscope 2021, 131, 1985.
E. G. Salentijn, B. van den Bergh, T. Forouzanfar, J Craniomaxillofac. Surg. 2013, 41, 630.
A. Kochhar, P. J. Byrne, Otolaryngol. Clin. North Am. 2013, 46, 759.
M. Zhang, R. Lin, X. Wang, J. Xue, C. Deng, C. Feng, H. Zhuang, J. Ma, C. Qin, L. Wan, J. Chang, C. Wu, Sci. Adv. 2020, 6, eaaz6725.
S. J. Hollister, Nat. Mater. 2006, 5, 590.
V. Karageorgiou, D. Kaplan, Biomaterials 2005, 26, 5474.
S. M. Mantila Roosa, J. M. Kemppainen, E. N. Moffitt, P. H. Krebsbach, S. J. Hollister, J. Biomed. Mater. Res., Part A 2010, 92, 359.
L. G. Sicchieri, G. E. Crippa, P. T. de Oliveira, M. M. Beloti, A. L. Rosa, J. Tissue Eng. Regen. Med. 2012, 6, 155.
Y. N. Zhao, J. J. Fan, Z. Q. Li, Y. W. Liu, Y. P. Wu, J. Liu, Artif. Organs 2017, 41, 199.
Z. Chen, X. Yan, S. Yin, L. Liu, X. Liu, G. Zhao, W. Ma, W. Qi, Z. Ren, H. Liao, M. Liu, D. Cai, H. Fang, Mater. Sci. Eng., C 2020, 106, 110289.
P. Y. Huri, B. Arda Ozilgen, D. L. Hutton, W. L. Grayson, Biomed. Mater. 2014, 9, 045003.
W. Li, F. Dai, S. Zhang, F. Xu, Z. Xu, S. Liao, L. Zeng, L. Song, F. Ai, ACS Appl. Mater. Interfaces 2022, 14, 20693.
J. C. Reichert, A. Cipitria, D. R. Epari, S. Saifzadeh, P. Krishnakanth, A. Berner, M. A. Woodruff, H. Schell, M. Mehta, M. A. Schuetz, G. N. Duda, D. W. Hutmacher, Sci. Transl. Med. 2012, 4, 141ra93.
D. W. Weisgerber, D. J. Milner, H. Lopez-Lake, M. Rubessa, S. Lotti, K. Polkoff, R. A. Hortensius, C. L. Flanagan, S. J. Hollister, M. B. Wheeler, B. A. C. Harley, Tissue Eng., Part A 2018, 24, 943.
P. Diloksumpan, R. V. Bolaños, S. Cokelaere, B. Pouran, J. de Grauw, M. van Rijen, R. van Weeren, R. Levato, J. Malda, Adv. Healthcare Mater. 2020, 9,.
J. J. Li, S. I. Roohani-Esfahani, C. R. Dunstan, T. Quach, R. Steck, S. Saifzadeh, P. Pivonka, H. Zreiqat, Biomed. Mater. 2016, 11, 015016.
L. Vidal, C. Kampleitner, S. Krissian, M. Brennan, O. Hoffmann, Y. Raymond, Y. Maazouz, M. P. Ginebra, P. Rosset, P. Layrolle, Sci. Rep. 2020, 10, 7068.
J. Henkel, F. M. Savi, A. Berner, S. Fountain, S. Saifzadeh, R. Steck, D. R. Epari, M. A. Woodruff, M. Knackstedt, M. A. Schuetz, D. W. Hutmacher, Bone 2021, 153, 116163.
S. Ghouse, N. Reznikov, O. R. Boughton, S. Babu, K. C. G. Ng, G. Blunn, J. P. Cobb, M. M. Stevens, J. R. T. Jeffers, Appl. Mater. Today 2019, 15, 377.
S. Singh, E. L. Nyberg, A. N. O'Sullivan, A. Farris, A. N. Rindone, N. Zhang, E. C. Whitehead, Y. Zhou, E. Mihaly, C. C. Achebe, W. Zbijewski, W. Grundy, D. Garlick, N. D. Jackson, T. Taguchi, C. Takawira, J. Lopez, M. J. Lopez, M. P. Grant, W. L. Grayson, Biomaterials 2022, 282, 121392.
C. A. Cook, K. C. Hahn, J. B. F. Morrissette-McAlmon, W. L. Grayson, Biomaterials 2015, 52, 376.
A. L. Farris, D. Lambrechts, Y. Zhou, N. Y. Zhang, N. Sarkar, M. C. Moorer, A. N. Rindone, E. L. Nyberg, A. Perdomo-Pantoja, S. J. Burris, K. Free, T. F. Witham, R. C. Riddle, W. L. Grayson, Biomaterials 2022, 280, 121318.
N. Zhang, S. Singh, S. Liu, W. Zbijewski, W. L. Grayson, 3D Print Med. 2022, 8, 9.
S. Suvarnapathaki, X. Wu, T. Zhang, M. A. Nguyen, A. A. Goulopoulos, B. Wu, G. Camci-Unal, Bioact. Mater. 2022, 13, 64.
F. Chamieh, A.-M. Collignon, B. R. Coyac, J. Lesieur, S. Ribes, J. Sadoine, A. Llorens, A. Nicoletti, D. Letourneur, M.-L. Colombier, M.-L. Colombier, S. N. Nazhat, P. Bouchard, C. Chaussain, G. Y. Rochefort, Sci. Rep. 2016, 6, 38814.
C. Perier-Metz, G. N. Duda, S. Checa, Front. Bioeng. Biotechnol. 2022, 10, 980727.
M. Jaber, P. S. P. Poh, G. N. Duda, S. Checa, Front. Bioeng. Biotechnol. 2022, 10, 995266.
C. Wu, A. Entezari, K. Zheng, J. Fang, H. Zreiqat, G. P. Steven, M. v. Swain, Q. Li, Nat. Comput. Sci. 2021, 1, 532.
S. H. Bartling, K. Peldschus, T. Rodt, F. Kral, H. Matthies, R. Kikinis, H. Becker, J. Comput. Assisted Tomogr. 2005, 29, 305.
J. Wang, Y. Shen, S. Yang, Int. J. Comput. Assisted Radiol. Surg. 2019, 14, 763.
L. F. P. Nicolielo, J. van Dessel, E. Shaheen, C. Letelier, M. Codari, C. Politis, I. Lambrichts, R. Jacobs, Int. J. Oral Sci. 2017, 9, 139.
J. A. Lynch, M. Grigoryan, A. Fierlinger, A. Guermazi, S. Zaim, D. B. MacLean, H. K. Genant, J. Orthop. Res. 2004, 22, 362.
H. H. Han, J. H. Shim, H. Lee, B. Y. Kim, J. S. Lee, J. W. Jung, W. S. Yun, C. H. Baek, J. W. Rhie, D. W. Cho, Plast. Reconstr. Surg. Global Open 2018, 6, e1975.
R. Xue, Q. Lai, S. Sun, L. Lai, X. Tang, J. Ci, Z. Zhang, Y. Wang, J. Craniofac. Surg. 2019, 30, e127.
T. S. Oh, W. S. Jeong, T. J. Chang, K. S. Koh, J. W. Choi, J. Craniofac. Surg. 2016, 27, 2020.
N. Kohli, J. C. Stoddart, R. J. van Arkel, Sci. Rep. 2021, 11, 10797.
K. L. Rafferty, S. W. Herring, F. Artese, J. Exp. Biol. 2000, 203, 2093.
E. Nyberg, A. O'Sullivan, W. Grayson, PLoS One 2019, 14, e0225007.
N. Jackson, M. Assad, D. Vollmer, J. Stanley, M. Chagnon, Toxicol. Pathol. 2019, 47, 280.
Hematologic Reference Ranges - Special Subjects - Merck Veterinary Manual, https://www.merckvetmanual.com/special-subjects/reference-guides/hematologic-reference-ranges (accessed January 2021).

Auteurs

Srujan Singh (S)

Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.

Yuxiao Zhou (Y)

Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Ashley L Farris (AL)

Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Emma C Whitehead (EC)

Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Ethan L Nyberg (EL)

Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Aine N O'Sullivan (AN)

Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Nicholas Y Zhang (NY)

Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Alexandra N Rindone (AN)

Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Chukwuebuka C Achebe (CC)

Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Wojciech Zbijewski (W)

Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Will Grundy (W)

StageBio Company, Mount Jackson, VA, 22842, USA.

David Garlick (D)

StageBio Company, Mount Jackson, VA, 22842, USA.

Nicolette D Jackson (ND)

Inotiv, Fort Collins, CO, 80524, USA.

Dara Kraitchman (D)

Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Jessica M Izzi (JM)

Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Joseph Lopez (J)

Pediatric Plastic and Reconstructive Surgery, Pediatric Head and Neck Surgery, AdventHealth for Children, Orlando, FL, 32803, USA.

Michael P Grant (MP)

Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Department of Plastic and Reconstructive Surgery, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

Warren L Grayson (WL)

Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, 21218, USA.
ORCID: 0000-0001-6099-6469

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Geometric Mismatch Promotes Anatomic Repair in...
questionsmedicales.fr › Eucaryotes › Animaux › Geometric Mismatch Promotes Anatomic Repair in...
questionsmedicales.fr › Équipement et fournitures › Prothèses et implants › Structures d'échafaudage tissulaires › Geometric Mismatch Promotes Anatomic Repair in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Sus scrofa › Porc miniature › Geometric Mismatch Promotes Anatomic Repair in...
questionsmedicales.fr › Sciences de l'information › Affichage de données › Infographie › Conception assistée par ordinateur › Impression tridimensionnelle › Geometric Mismatch Promotes Anatomic Repair in...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Matériaux biocompatibles › Geometric Mismatch Promotes Anatomic Repair in...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Remodelage osseux › Régénération osseuse › Geometric Mismatch Promotes Anatomic Repair in...
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