Crystal Structure of the ORP8 Lipid Transport ORD Domain: Model of Lipid Transport.
ER
ORD
ORP8
PI4P
PS
lipid transport
plasma membrane
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
31 07 2023
31 07 2023
Historique:
received:
17
07
2023
revised:
28
07
2023
accepted:
29
07
2023
medline:
14
8
2023
pubmed:
11
8
2023
entrez:
11
8
2023
Statut:
epublish
Résumé
ORPs are lipid-transport proteins belonging to the oxysterol-binding protein family. They facilitate the transfer of lipids between different intracellular membranes, such as the ER and plasma membrane. We have solved the crystal structure of the ORP8 lipid transport domain (ORD8). The ORD8 exhibited a β-barrel fold composed of anti-parallel β-strands, with three α-helices replacing β-strands on one side. This mixed alpha-beta structure was consistent with previously solved structures of ORP2 and ORP3. A large cavity (≈1860 Å
Identifiants
pubmed: 37566053
pii: cells12151974
doi: 10.3390/cells12151974
pmc: PMC10417380
pii:
doi:
Substances chimiques
Carrier Proteins
0
Lipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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