Equol and Resveratrol Improve Bone Turnover Biomarkers in Postmenopausal Women: A Clinical Trial.
bone metabolism markers
bone mineral density
equol
menopause
resveratrol
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Jul 2023
27 Jul 2023
Historique:
received:
13
06
2023
revised:
23
07
2023
accepted:
24
07
2023
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
Estrogen deficiency is a major cause of loss of postmenopausal bone mineral density (BMD). This study aimed to evaluate the effects of equol and resveratrol on bone turnover biomarkers in postmenopausal women. Sixty healthy postmenopausal women were randomly assigned to receive 200 mg fermented soy containing 10 mg equol and 25 mg resveratrol or a placebo for 12 months. Whole-body BMD and bone turnover biomarkers, such as deoxypyridinoline (DPD), tartrate-resistant acid phosphatase 5b (TRACP-5b), osteocalcin, and bone-specific alkaline phosphatase (BAP), were measured at baseline and after 12 months of treatment. At the end of treatment, DPD, osteocalcin, and BAP significantly improved in the active group (
Identifiants
pubmed: 37569440
pii: ijms241512063
doi: 10.3390/ijms241512063
pmc: PMC10419295
pii:
doi:
Substances chimiques
Equol
531-95-3
Resveratrol
Q369O8926L
Tartrate-Resistant Acid Phosphatase
EC 3.1.3.2
Osteocalcin
104982-03-8
Alkaline Phosphatase
EC 3.1.3.1
Biomarkers
0
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Menopause. 2007 Sep-Oct;14(5):866-74
pubmed: 17464237
Biomed Res Int. 2022 Oct 25;2022:8862278
pubmed: 36330454
Int J Mol Sci. 2022 Jan 25;23(3):
pubmed: 35163300
Food Funct. 2023 Jun 6;14(11):4966-4980
pubmed: 37212033
Br J Nutr. 2014 Mar 14;111(5):836-46
pubmed: 24073920
Nutrients. 2020 Jul 09;12(7):
pubmed: 32660008
Osteoporos Int. 2020 Oct;31(10):1853-1864
pubmed: 32524173
J Bone Miner Res. 2020 Nov;35(11):2121-2131
pubmed: 32564438
Ann N Y Acad Sci. 2009 Sep;1173 Suppl 1:E60-3
pubmed: 19751416
J Altern Complement Med. 2018 Jul;24(7):701-708
pubmed: 29722549
Ann N Y Acad Sci. 2015 Aug;1348(1):75-85
pubmed: 26200189
JAMA. 2004 Jul 7;292(1):65-74
pubmed: 15238592
Br Med Bull. 2020 May 15;133(1):105-117
pubmed: 32282039
Immun Ageing. 2013 Jul 11;10(1):28
pubmed: 23842073
Drug Metab Dispos. 2004 Dec;32(12):1377-82
pubmed: 15333514
Crit Rev Toxicol. 2020 May;50(5):439-462
pubmed: 32744480
Clin Chim Acta. 2019 Nov;498:101-107
pubmed: 31425674
Nutr Rev. 2011 Aug;69(8):432-48
pubmed: 21790611
J Transl Med. 2014 Aug 14;12:223
pubmed: 25115686
Asian Pac J Trop Med. 2012 Mar;5(3):243-8
pubmed: 22305793
Menopause. 2011 May;18(5):563-74
pubmed: 21252728
Biomark Res. 2017 May 18;5:18
pubmed: 28529755
Am J Clin Nutr. 2015 Sep;102(3):695-703
pubmed: 26245807
Mol Nutr Food Res. 2010 Jan;54(1):7-16
pubmed: 20013887
Menopause. 2012 Feb;19(2):202-10
pubmed: 21934634
Menopause. 2009 Jan-Feb;16(1):141-8
pubmed: 19131846
Ann Clin Biochem. 2014 Mar;51(Pt 2):189-202
pubmed: 24399365
J Nutr Biochem. 2002 Mar;13(3):130-137
pubmed: 11893477
Mayo Clin Proc. 2015 Jan;90(1):53-62
pubmed: 25481833
Curr Pharm Des. 2020;26(45):5837-5843
pubmed: 33208061
Maturitas. 2017 Feb;96:77-83
pubmed: 28041599
Osteoporos Int. 2012 May;23(5):1571-80
pubmed: 21901480
Mol Nutr Food Res. 2009 May;53 Suppl 1:S7-15
pubmed: 19194969
Am J Clin Nutr. 2017 Sep;106(3):909-920
pubmed: 28768651