Molecular Mechanisms of Endothelialitis in SARS-CoV-2 Infection: Evidence for VE-Cadherin Cleavage by ACE2.
ACE2
SARS-CoV-2 infection
VE-cadherin
endothelium
long COVID syndrome
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Aug 2023
07 Aug 2023
Historique:
received:
07
06
2023
revised:
24
07
2023
accepted:
28
07
2023
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
Long COVID-19 syndrome appears after Severe Acute Respiratory Syndrome-Corona Virus (SARS-CoV-2) infection with acute damage to microcapillaries, microthrombi, and endothelialitis. However, the mechanisms involved in these processes remain to be elucidated. All blood vessels are lined with a monolayer of endothelial cells called vascular endothelium, which provides a the major function is to prevent coagulation. A component of endothelial cell junctions is VE-cadherin, which is responsible for maintaining the integrity of the vessels through homophilic interactions of its Ca
Identifiants
pubmed: 37569899
pii: ijms241512525
doi: 10.3390/ijms241512525
pmc: PMC10419376
pii:
doi:
Substances chimiques
cadherin 5
0
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Cadherins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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