Effect of a 12-Week Polyphenol Rutin Intervention on Markers of Pancreatic β-Cell Function and Gut Microbiota in Adults with Overweight without Diabetes.
gut microbiota
pancreas β-cell function
prebiotic polyphenol rutin
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
28 Jul 2023
28 Jul 2023
Historique:
received:
01
07
2023
revised:
18
07
2023
accepted:
21
07
2023
medline:
14
8
2023
pubmed:
12
8
2023
entrez:
12
8
2023
Statut:
epublish
Résumé
Supplementation with prebiotic polyphenol rutin is a potential dietary therapy for type 2 diabetes prevention in adults with obesity, based on previous glycaemic improvement in transgenic mouse models. Gut microbiota are hypothesised to underpin these effects. We investigated the effect of rutin supplementation on pancreatic β-cell function measured as C-peptide/glucose ratio, and 16S rRNA gene-based gut microbiota profiles, in a cohort of individuals with overweight plus normoglycaemia or prediabetes. Eighty-seven participants were enrolled, aged 18-65 years with BMI of 23-35 kg/m
Identifiants
pubmed: 37571297
pii: nu15153360
doi: 10.3390/nu15153360
pmc: PMC10420824
pii:
doi:
Substances chimiques
Polyphenols
0
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : High-Value Nutrition National Science Challenge, New Zealand
ID : 3710040
Organisme : Maurice Wilkins Centre Flexible Research Programme
ID : 3713851
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