Development of mabuterol transdermal patch: Molecular mechanism study of ion-pair improving patch stability.
Ion-pair
Mabuterol
Molecular interaction
Stability
Transdermal patch
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
25 Sep 2023
25 Sep 2023
Historique:
received:
19
04
2023
revised:
28
07
2023
accepted:
09
08
2023
medline:
12
9
2023
pubmed:
13
8
2023
entrez:
12
8
2023
Statut:
ppublish
Résumé
This paper aimed to prepare a Mabuterol (MAB) patch for treating asthma by ion-pair strategy to overcome the drug's thermal instability and elucidate the molecular mechanisms of the stabilization effect. The formulation factor, including counter-ion and pressure-sensitive adhesive (PSA), was optimized by the stability and in vitro skin permeation studies. The molecular mechanism of ion-pair stability was characterized using TGA, Raman, FT-IR, NMR, XPS, and molecular modeling. The optimized patch comprised MAB-Lactic acid (MAB-LA) and hydroxyl adhesive (AAOH) as the matrix, with Q = 126.47 ± 9.75 μg/cm
Identifiants
pubmed: 37572858
pii: S0378-5173(23)00722-6
doi: 10.1016/j.ijpharm.2023.123302
pii:
doi:
Substances chimiques
mabuterol
R4K19W6S7Q
Adhesives
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
123302Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.