Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters.
RNA polymerase II
core promoter architecture
preinitiation complex
transcription factor IID
transcription initiation
transcription start site selection
Journal
Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
19
04
2023
revised:
19
07
2023
accepted:
19
07
2023
pmc-release:
01
10
2024
medline:
18
9
2023
pubmed:
14
8
2023
entrez:
13
8
2023
Statut:
ppublish
Résumé
Core promoters are sites where transcriptional regulatory inputs of a gene are integrated to direct the assembly of the preinitiation complex (PIC) and RNA polymerase II (Pol II) transcription output. Until now, core promoter functions have been investigated by distinct methods, including Pol II transcription initiation site mappings and structural characterization of PICs on distinct promoters. Here, we bring together these previously unconnected observations and hypothesize how, on metazoan TATA promoters, the precisely structured building up of transcription factor (TF) IID-based PICs results in sharp transcription start site (TSS) selection; or, in contrast, how the less strictly controlled positioning of the TATA-less promoter DNA relative to TFIID-core PIC components results in alternative broad TSS selections by Pol II.
Identifiants
pubmed: 37574371
pii: S0968-0004(23)00175-5
doi: 10.1016/j.tibs.2023.07.009
pmc: PMC10529448
mid: NIHMS1924381
pii:
doi:
Substances chimiques
Transcription Factor TFIID
0
RNA Polymerase II
EC 2.7.7.-
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
839-848Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM139564
Pays : United States
Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.
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