Immunoregulatory macrophages modify local pulmonary immunity and ameliorate hypoxic-pulmonary hypertension.

Macrophages play a central role in the onset and progression of vascular disease in pulmonary hypertension (PH) and cell-based immunotherapies aimed at treating vascular remodeling are lacking. To evaluate the effect of pulmonary administration of macrophages modified to have an anti-inflammatory/pro-resolving phenotype in attenuating early pulmonary inflammation and progression of experimentally induced PH. Mouse bone marrow derived macrophages (BMDMs) were polarized M2 Adoptive transfer of M2